Herpes simplex type 2 pneumonia
Extensive reviews of pulmonary infections in AIDS have reported few herpetic infections. Generally these infections are due to Herpes simplex type 1. Pneumonia due to herpes type 2 is extremely rare. We describe a 40 year-old HIV positive woman who complained of fever, cough and dyspnea for seven ye...
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| Format: | Article |
| Language: | English |
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Elsevier
2002-01-01
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| Series: | Brazilian Journal of Infectious Diseases |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702002000600006 |
| _version_ | 1818403511230005248 |
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| author | Calore Edenilson Eduardo |
| author_facet | Calore Edenilson Eduardo |
| author_sort | Calore Edenilson Eduardo |
| collection | DOAJ |
| description | Extensive reviews of pulmonary infections in AIDS have reported few herpetic infections. Generally these infections are due to Herpes simplex type 1. Pneumonia due to herpes type 2 is extremely rare. We describe a 40 year-old HIV positive woman who complained of fever, cough and dyspnea for seven years. She had signs of heart failure and the appearance of her genital vesicles was highly suggestive of genital herpes. Echocardiography showed marked pulmonary hypertension, right ventricular hypertrophy and tricuspid insufficiency. After a few days of hospitalization she was treated with Aciclovir and later with Ganciclovir. An open pulmonary biopsy revealed an interstitial inflammation, localized in the alveolar walls. Some pulmonary arteries had widened walls and focal hyaline degeneration. Immunohistochemistry indicated that the nuclei had herpes simplex virus type 2 in many endothelial cells (including vessels with widened walls), macrophages in the alveolar septa and pneumocytes. There was clinical improvement after treatment for herpes. We concluded that as a consequence of herpes infection, endothelial involvement and interstitial inflammation supervene, with thickening of vascular walls and partial obliteration of the vessel lumen. A direct consequence of these changes in pulmonary vasculature was pulmonary hypertension followed by heart failure. |
| first_indexed | 2024-12-14T08:25:25Z |
| format | Article |
| id | doaj.art-f3abb6afd1b74945ae7cb97cef971c55 |
| institution | Directory Open Access Journal |
| issn | 1413-8670 1678-4391 |
| language | English |
| last_indexed | 2024-12-14T08:25:25Z |
| publishDate | 2002-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Brazilian Journal of Infectious Diseases |
| spelling | doaj.art-f3abb6afd1b74945ae7cb97cef971c552022-12-21T23:09:40ZengElsevierBrazilian Journal of Infectious Diseases1413-86701678-43912002-01-0166305308Herpes simplex type 2 pneumoniaCalore Edenilson EduardoExtensive reviews of pulmonary infections in AIDS have reported few herpetic infections. Generally these infections are due to Herpes simplex type 1. Pneumonia due to herpes type 2 is extremely rare. We describe a 40 year-old HIV positive woman who complained of fever, cough and dyspnea for seven years. She had signs of heart failure and the appearance of her genital vesicles was highly suggestive of genital herpes. Echocardiography showed marked pulmonary hypertension, right ventricular hypertrophy and tricuspid insufficiency. After a few days of hospitalization she was treated with Aciclovir and later with Ganciclovir. An open pulmonary biopsy revealed an interstitial inflammation, localized in the alveolar walls. Some pulmonary arteries had widened walls and focal hyaline degeneration. Immunohistochemistry indicated that the nuclei had herpes simplex virus type 2 in many endothelial cells (including vessels with widened walls), macrophages in the alveolar septa and pneumocytes. There was clinical improvement after treatment for herpes. We concluded that as a consequence of herpes infection, endothelial involvement and interstitial inflammation supervene, with thickening of vascular walls and partial obliteration of the vessel lumen. A direct consequence of these changes in pulmonary vasculature was pulmonary hypertension followed by heart failure.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702002000600006Herpes pneumoniaAIDSopportunistic infectionspulmonary hypertensionherpes simplex |
| spellingShingle | Calore Edenilson Eduardo Herpes simplex type 2 pneumonia Brazilian Journal of Infectious Diseases Herpes pneumonia AIDS opportunistic infections pulmonary hypertension herpes simplex |
| title | Herpes simplex type 2 pneumonia |
| title_full | Herpes simplex type 2 pneumonia |
| title_fullStr | Herpes simplex type 2 pneumonia |
| title_full_unstemmed | Herpes simplex type 2 pneumonia |
| title_short | Herpes simplex type 2 pneumonia |
| title_sort | herpes simplex type 2 pneumonia |
| topic | Herpes pneumonia AIDS opportunistic infections pulmonary hypertension herpes simplex |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702002000600006 |
| work_keys_str_mv | AT caloreedenilsoneduardo herpessimplextype2pneumonia |