Epigenetic Mechanism and Therapeutic Implications of Atrial Fibrillation
Atrial fibrillation (AF) is the most common arrhythmia attacking 1. 5–2.0% of general population worldwide. It has a significant impact on morbidity and mortality globally and its prevalence increases exponentially with age. Therapies like catheter ablation or conventional antiarrhythmic drugs have...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-01-01
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| Series: | Frontiers in Cardiovascular Medicine |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fcvm.2021.763824/full |
| _version_ | 1798014662684442624 |
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| author | Dan Li Jiali Nie Yu Han Li Ni |
| author_facet | Dan Li Jiali Nie Yu Han Li Ni |
| author_sort | Dan Li |
| collection | DOAJ |
| description | Atrial fibrillation (AF) is the most common arrhythmia attacking 1. 5–2.0% of general population worldwide. It has a significant impact on morbidity and mortality globally and its prevalence increases exponentially with age. Therapies like catheter ablation or conventional antiarrhythmic drugs have not provided effective solution to the recurrence for AF over the past decades. Over 100 genetic loci have been discovered to be associated with AF by Genome-wide association studies (GWAS) but none has led to a therapy. Recently potential involvement of epigenetics (DNA methylation, histone modification, and non-coding RNAs) in the initiation and maintenance of AF has partly emerged as proof-of-concept in the mechanism and management of AF. Here we reviewed the epigenetic features involved in AF pathophysiology and provided an update of their implications in AF therapy. |
| first_indexed | 2024-04-11T15:21:59Z |
| format | Article |
| id | doaj.art-f3ae1486158b4d638b8a0981ac5ae60b |
| institution | Directory Open Access Journal |
| issn | 2297-055X |
| language | English |
| last_indexed | 2024-04-11T15:21:59Z |
| publishDate | 2022-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cardiovascular Medicine |
| spelling | doaj.art-f3ae1486158b4d638b8a0981ac5ae60b2022-12-22T04:16:21ZengFrontiers Media S.A.Frontiers in Cardiovascular Medicine2297-055X2022-01-01810.3389/fcvm.2021.763824763824Epigenetic Mechanism and Therapeutic Implications of Atrial FibrillationDan LiJiali NieYu HanLi NiAtrial fibrillation (AF) is the most common arrhythmia attacking 1. 5–2.0% of general population worldwide. It has a significant impact on morbidity and mortality globally and its prevalence increases exponentially with age. Therapies like catheter ablation or conventional antiarrhythmic drugs have not provided effective solution to the recurrence for AF over the past decades. Over 100 genetic loci have been discovered to be associated with AF by Genome-wide association studies (GWAS) but none has led to a therapy. Recently potential involvement of epigenetics (DNA methylation, histone modification, and non-coding RNAs) in the initiation and maintenance of AF has partly emerged as proof-of-concept in the mechanism and management of AF. Here we reviewed the epigenetic features involved in AF pathophysiology and provided an update of their implications in AF therapy.https://www.frontiersin.org/articles/10.3389/fcvm.2021.763824/fullatrial fibrillationepigenetic regulationDNA methylationhistone modificationnon-coding RNAs |
| spellingShingle | Dan Li Jiali Nie Yu Han Li Ni Epigenetic Mechanism and Therapeutic Implications of Atrial Fibrillation Frontiers in Cardiovascular Medicine atrial fibrillation epigenetic regulation DNA methylation histone modification non-coding RNAs |
| title | Epigenetic Mechanism and Therapeutic Implications of Atrial Fibrillation |
| title_full | Epigenetic Mechanism and Therapeutic Implications of Atrial Fibrillation |
| title_fullStr | Epigenetic Mechanism and Therapeutic Implications of Atrial Fibrillation |
| title_full_unstemmed | Epigenetic Mechanism and Therapeutic Implications of Atrial Fibrillation |
| title_short | Epigenetic Mechanism and Therapeutic Implications of Atrial Fibrillation |
| title_sort | epigenetic mechanism and therapeutic implications of atrial fibrillation |
| topic | atrial fibrillation epigenetic regulation DNA methylation histone modification non-coding RNAs |
| url | https://www.frontiersin.org/articles/10.3389/fcvm.2021.763824/full |
| work_keys_str_mv | AT danli epigeneticmechanismandtherapeuticimplicationsofatrialfibrillation AT jialinie epigeneticmechanismandtherapeuticimplicationsofatrialfibrillation AT yuhan epigeneticmechanismandtherapeuticimplicationsofatrialfibrillation AT lini epigeneticmechanismandtherapeuticimplicationsofatrialfibrillation |