In vivo Study of the Osteoregenerative Potential of Polymer Membranes Consisting of Chitosan and Carbon Nanotubes
Biomaterials with the hydroxyapatite and biopolymers such as chitosan derived of crustaceans are is an alternative for bone repair. Carbon nanotubes have been a focus of interest because they can ameliorate the biomechanical properties of biomaterials. The objective of this study was to evaluate the...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Associação Brasileira de Metalurgia e Materiais (ABM); Associação Brasileira de Cerâmica (ABC); Associação Brasileira de Polímeros (ABPol)
2017-05-01
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| Series: | Materials Research |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-14392017000300819&tlng=en |
| _version_ | 1818974923081646080 |
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| author | Marcelo Rodrigues da Cunha Marianna Carla Alves Amanda Regina Alves Calegari Amilton Iatecola Ewerton Alexandre Galdeano Talita Lopes Galdeano Marcelo de Azevedo e Souza Munhoz Ana Maria de Guzzi Plepis Virginia da Conceição Amaro Martins Marilia Marta Horn |
| author_facet | Marcelo Rodrigues da Cunha Marianna Carla Alves Amanda Regina Alves Calegari Amilton Iatecola Ewerton Alexandre Galdeano Talita Lopes Galdeano Marcelo de Azevedo e Souza Munhoz Ana Maria de Guzzi Plepis Virginia da Conceição Amaro Martins Marilia Marta Horn |
| author_sort | Marcelo Rodrigues da Cunha |
| collection | DOAJ |
| description | Biomaterials with the hydroxyapatite and biopolymers such as chitosan derived of crustaceans are is an alternative for bone repair. Carbon nanotubes have been a focus of interest because they can ameliorate the biomechanical properties of biomaterials. The objective of this study was to evaluate these materials in the repair of cranial defects in rats. The animals were divided in groups: without implant (G1), implanted with the chitosan/carbon nanotube membrane (G2), and chitosan/nanotube membrane mineralized with hydroxyapatite (G3). The animals were sacrificed 5 weeks after surgery and the skulls were removed for analysis of the defect area. The results showed absence of chronic inflammatory and little bone neoformation in the defect area of all groups. In G2 and G3 there was lack of reabsorption of the biomaterial that were encapsulated by connective tissue. In conclusion, the biomaterials were biocompatible, but their specific physicochemical properties did not indicate a considerable osteoregenerative capacity. |
| first_indexed | 2024-12-20T15:47:46Z |
| format | Article |
| id | doaj.art-f3ae14f9f9394ba2b7fe7ad3a333b5e0 |
| institution | Directory Open Access Journal |
| issn | 1516-1439 |
| language | English |
| last_indexed | 2024-12-20T15:47:46Z |
| publishDate | 2017-05-01 |
| publisher | Associação Brasileira de Metalurgia e Materiais (ABM); Associação Brasileira de Cerâmica (ABC); Associação Brasileira de Polímeros (ABPol) |
| record_format | Article |
| series | Materials Research |
| spelling | doaj.art-f3ae14f9f9394ba2b7fe7ad3a333b5e02022-12-21T19:34:53ZengAssociação Brasileira de Metalurgia e Materiais (ABM); Associação Brasileira de Cerâmica (ABC); Associação Brasileira de Polímeros (ABPol)Materials Research1516-14392017-05-0120381982510.1590/1980-5373-mr-2016-1112In vivo Study of the Osteoregenerative Potential of Polymer Membranes Consisting of Chitosan and Carbon NanotubesMarcelo Rodrigues da CunhaMarianna Carla AlvesAmanda Regina Alves CalegariAmilton IatecolaEwerton Alexandre GaldeanoTalita Lopes GaldeanoMarcelo de Azevedo e Souza MunhozAna Maria de Guzzi PlepisVirginia da Conceição Amaro MartinsMarilia Marta HornBiomaterials with the hydroxyapatite and biopolymers such as chitosan derived of crustaceans are is an alternative for bone repair. Carbon nanotubes have been a focus of interest because they can ameliorate the biomechanical properties of biomaterials. The objective of this study was to evaluate these materials in the repair of cranial defects in rats. The animals were divided in groups: without implant (G1), implanted with the chitosan/carbon nanotube membrane (G2), and chitosan/nanotube membrane mineralized with hydroxyapatite (G3). The animals were sacrificed 5 weeks after surgery and the skulls were removed for analysis of the defect area. The results showed absence of chronic inflammatory and little bone neoformation in the defect area of all groups. In G2 and G3 there was lack of reabsorption of the biomaterial that were encapsulated by connective tissue. In conclusion, the biomaterials were biocompatible, but their specific physicochemical properties did not indicate a considerable osteoregenerative capacity.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-14392017000300819&tlng=enChitosanCarbon nanotubesHydroxyapatitePolymer blend |
| spellingShingle | Marcelo Rodrigues da Cunha Marianna Carla Alves Amanda Regina Alves Calegari Amilton Iatecola Ewerton Alexandre Galdeano Talita Lopes Galdeano Marcelo de Azevedo e Souza Munhoz Ana Maria de Guzzi Plepis Virginia da Conceição Amaro Martins Marilia Marta Horn In vivo Study of the Osteoregenerative Potential of Polymer Membranes Consisting of Chitosan and Carbon Nanotubes Materials Research Chitosan Carbon nanotubes Hydroxyapatite Polymer blend |
| title | In vivo Study of the Osteoregenerative Potential of Polymer Membranes Consisting of Chitosan and Carbon Nanotubes |
| title_full | In vivo Study of the Osteoregenerative Potential of Polymer Membranes Consisting of Chitosan and Carbon Nanotubes |
| title_fullStr | In vivo Study of the Osteoregenerative Potential of Polymer Membranes Consisting of Chitosan and Carbon Nanotubes |
| title_full_unstemmed | In vivo Study of the Osteoregenerative Potential of Polymer Membranes Consisting of Chitosan and Carbon Nanotubes |
| title_short | In vivo Study of the Osteoregenerative Potential of Polymer Membranes Consisting of Chitosan and Carbon Nanotubes |
| title_sort | in vivo study of the osteoregenerative potential of polymer membranes consisting of chitosan and carbon nanotubes |
| topic | Chitosan Carbon nanotubes Hydroxyapatite Polymer blend |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-14392017000300819&tlng=en |
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