Single Turnover Autophosphorylation Cycle of the PKA RIIβ Holoenzyme.

Single Turnover Autophosphorylation Cycle of the PKA RIIβ Holoenzyme.

To provide tight spatiotemporal signaling control, the cyclic adenosine monophosphate (cAMP)-dependent protein kinase (PKA) holoenzyme typically nucleates a macromolecular complex or a "PKA signalosome." Using the RIIβ holoenzyme as a prototype, we show how autophosphorylation/dephosphoryl...

Full description

Bibliographic Details
Main Authors: Ping Zhang, Matthias J Knape, Lalima G Ahuja, Malik M Keshwani, Charles C King, Mira Sastri, Friedrich W Herberg, Susan S Taylor
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-07-01
Series:PLoS Biology
Online Access:https://doi.org/10.1371/journal.pbio.1002192

Similar Items

Similar Items