Syphilis in the Americas: a protocol for a systematic review of syphilis prevalence and incidence in four high-risk groups, 1980–2016
Abstract Background Syphilis infection has recently resurfaced as a significant public health problem. Although there has been a tremendous amount of research on the epidemiology of syphilis, there has been limited work done to synthesize the extensive body of research and systematically estimate pa...
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| Format: | Article |
| Language: | English |
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BMC
2017-10-01
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| Series: | Systematic Reviews |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s13643-017-0595-3 |
| _version_ | 1811319498028875776 |
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| author | Ken Kitayama Eddy R. Segura Jordan E. Lake Amaya G. Perez-Brumer Catherine E. Oldenburg Bethany A. Myers Paria Pourjavaheri Chinomnso N. Okorie Robinson L. Cabello Jesse L. Clark |
| author_facet | Ken Kitayama Eddy R. Segura Jordan E. Lake Amaya G. Perez-Brumer Catherine E. Oldenburg Bethany A. Myers Paria Pourjavaheri Chinomnso N. Okorie Robinson L. Cabello Jesse L. Clark |
| author_sort | Ken Kitayama |
| collection | DOAJ |
| description | Abstract Background Syphilis infection has recently resurfaced as a significant public health problem. Although there has been a tremendous amount of research on the epidemiology of syphilis, there has been limited work done to synthesize the extensive body of research and systematically estimate patterns of disease within high-risk groups in the Americas. The purpose of this systematic review and meta-analysis is to (1) summarize recent patterns of syphilis infection in North and South America among four high-risk groups (MSM, transgender women, sex workers, and incarcerated individuals) from 1980 to 2016, (2) identify and differentiate regional geographic epidemiologic characteristics, and (3) compare the epidemics of the economically developed countries of North America from the developing countries and public health systems of Latin America and the Caribbean. Methods/design Primary studies reporting syphilis prevalence and/or incidence in at least one of the four high-risk groups will be identified from Medline/PubMed, Embase, Lilacs, SciELO, The Cochrane Library, Web of Science, Scopus, ProQuest, CINAHL, Clase, and Periódica, as well as “gray” literature sources (conference abstracts, country reports, etc.). Studies published from 1980 through 2016 will be included. Data will be extracted from studies meeting inclusion and exclusion criteria and a random effects meta-analysis of prevalence and incidence estimates will be conducted. Heterogeneity, risk of bias, and publication bias will be assessed. Pooled prevalence and incidence estimates will be calculated for comparisons based on geographic region, risk factors, and time period. Discussion Our systematic review and meta-analysis aims to contribute to an improved understanding of global epidemiologic patterns of syphilis infection in most-at-risk populations. Through systematic classification of the existing literature, and comparison of disease patterns across regional, temporal and socio-behavioral differences, we hope to improve public health surveillance and improve efforts to control the spread of disease across the Americas. Systematic review registration PROSPERO CRD42016047306. |
| first_indexed | 2024-04-13T12:43:17Z |
| format | Article |
| id | doaj.art-f3b1d60d1da64751b6c7c1dd505d267f |
| institution | Directory Open Access Journal |
| issn | 2046-4053 |
| language | English |
| last_indexed | 2024-04-13T12:43:17Z |
| publishDate | 2017-10-01 |
| publisher | BMC |
| record_format | Article |
| series | Systematic Reviews |
| spelling | doaj.art-f3b1d60d1da64751b6c7c1dd505d267f2022-12-22T02:46:27ZengBMCSystematic Reviews2046-40532017-10-01611710.1186/s13643-017-0595-3Syphilis in the Americas: a protocol for a systematic review of syphilis prevalence and incidence in four high-risk groups, 1980–2016Ken Kitayama0Eddy R. Segura1Jordan E. Lake2Amaya G. Perez-Brumer3Catherine E. Oldenburg4Bethany A. Myers5Paria Pourjavaheri6Chinomnso N. Okorie7Robinson L. Cabello8Jesse L. Clark9Department of Medicine, Division of Infectious Diseases, UCLA South American Program in HIV Prevention Research (SAPHIR), David Geffen School of Medicine at UCLADepartment of Medicine, Division of Infectious Diseases, David Geffen School of Medicine at UCLADepartment of Medicine, Division of Infectious Diseases, McGovern Medical School at the University of Texas Health Science Center at HoustonColumbia University Mailman School of Public HealthSan Francisco School of Medicine, Francis I. Proctor Foundation for Research in Ophthalmology, Department of Ophthalmology, and Department of Epidemiology and Biostatistics, University of CaliforniaLouise M. Darling Biomedical Library at UCLADepartment of Medicine, Division of Infectious Diseases, David Geffen School of Medicine at UCLADepartment of Biology, San Francisco State UniversityAsociación Civil Vía LibreDepartment of Medicine, Division of Infectious Diseases, David Geffen School of Medicine at UCLAAbstract Background Syphilis infection has recently resurfaced as a significant public health problem. Although there has been a tremendous amount of research on the epidemiology of syphilis, there has been limited work done to synthesize the extensive body of research and systematically estimate patterns of disease within high-risk groups in the Americas. The purpose of this systematic review and meta-analysis is to (1) summarize recent patterns of syphilis infection in North and South America among four high-risk groups (MSM, transgender women, sex workers, and incarcerated individuals) from 1980 to 2016, (2) identify and differentiate regional geographic epidemiologic characteristics, and (3) compare the epidemics of the economically developed countries of North America from the developing countries and public health systems of Latin America and the Caribbean. Methods/design Primary studies reporting syphilis prevalence and/or incidence in at least one of the four high-risk groups will be identified from Medline/PubMed, Embase, Lilacs, SciELO, The Cochrane Library, Web of Science, Scopus, ProQuest, CINAHL, Clase, and Periódica, as well as “gray” literature sources (conference abstracts, country reports, etc.). Studies published from 1980 through 2016 will be included. Data will be extracted from studies meeting inclusion and exclusion criteria and a random effects meta-analysis of prevalence and incidence estimates will be conducted. Heterogeneity, risk of bias, and publication bias will be assessed. Pooled prevalence and incidence estimates will be calculated for comparisons based on geographic region, risk factors, and time period. Discussion Our systematic review and meta-analysis aims to contribute to an improved understanding of global epidemiologic patterns of syphilis infection in most-at-risk populations. Through systematic classification of the existing literature, and comparison of disease patterns across regional, temporal and socio-behavioral differences, we hope to improve public health surveillance and improve efforts to control the spread of disease across the Americas. Systematic review registration PROSPERO CRD42016047306.http://link.springer.com/article/10.1186/s13643-017-0595-3SyphilisPrevalenceIncidenceMen who have sex with menTransgender womenSex workers |
| spellingShingle | Ken Kitayama Eddy R. Segura Jordan E. Lake Amaya G. Perez-Brumer Catherine E. Oldenburg Bethany A. Myers Paria Pourjavaheri Chinomnso N. Okorie Robinson L. Cabello Jesse L. Clark Syphilis in the Americas: a protocol for a systematic review of syphilis prevalence and incidence in four high-risk groups, 1980–2016 Systematic Reviews Syphilis Prevalence Incidence Men who have sex with men Transgender women Sex workers |
| title | Syphilis in the Americas: a protocol for a systematic review of syphilis prevalence and incidence in four high-risk groups, 1980–2016 |
| title_full | Syphilis in the Americas: a protocol for a systematic review of syphilis prevalence and incidence in four high-risk groups, 1980–2016 |
| title_fullStr | Syphilis in the Americas: a protocol for a systematic review of syphilis prevalence and incidence in four high-risk groups, 1980–2016 |
| title_full_unstemmed | Syphilis in the Americas: a protocol for a systematic review of syphilis prevalence and incidence in four high-risk groups, 1980–2016 |
| title_short | Syphilis in the Americas: a protocol for a systematic review of syphilis prevalence and incidence in four high-risk groups, 1980–2016 |
| title_sort | syphilis in the americas a protocol for a systematic review of syphilis prevalence and incidence in four high risk groups 1980 2016 |
| topic | Syphilis Prevalence Incidence Men who have sex with men Transgender women Sex workers |
| url | http://link.springer.com/article/10.1186/s13643-017-0595-3 |
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