CYP2C19 loss-of-function is associated with increased risk of hypertension in a Hakka population: a case-control study
Abstract Background Genetic factors have a certain proportion in the risk factors of hypertension. The purpose was to investigate the relationship of cytochrome P450 2C19 (CYP2C19) polymorphisms with hypertension in Hakka population. Methods The study included 1,872 hypertensive patients and 1,110 c...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2023-04-01
|
| Series: | BMC Cardiovascular Disorders |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12872-023-03207-w |
| _version_ | 1827970694740180992 |
|---|---|
| author | Nan Cai Cunren Li Xianfang Gu Wenfeng Zeng Jiawei Zhong Jingfeng Liu Guopeng Zeng Junxing Zhu Haifeng Hong |
| author_facet | Nan Cai Cunren Li Xianfang Gu Wenfeng Zeng Jiawei Zhong Jingfeng Liu Guopeng Zeng Junxing Zhu Haifeng Hong |
| author_sort | Nan Cai |
| collection | DOAJ |
| description | Abstract Background Genetic factors have a certain proportion in the risk factors of hypertension. The purpose was to investigate the relationship of cytochrome P450 2C19 (CYP2C19) polymorphisms with hypertension in Hakka population. Methods The study included 1,872 hypertensive patients and 1,110 controls. The genotypes of CYP2C19 rs4244285 and rs4986893 of all individuals were detected and analyzed. Results The genotype and allele distributions of CYP2C19 rs4244285 were significantly different between hypertension group and control group. The CYP2C19 *1/*1 genotype was the most predominant among the subjects (40.8%), followed by the CYP2C19 *1/*2 genotype (40.5%). The percentage of CYP2C19*1, *2, and *3 allele was 64.2%, 30.8%, and 5.0%, respectively. The proportion of intermediate metabolizers (IM) (49.3% vs. 42.9%), poor metabolizers (PM) (14.3% vs. 8.9%) (P < 0.001), and CYP2C19*2 allele (33.8% vs. 25.7%, P < 0.001) in hypertension group was significantly higher than that in control group. Multivariate logistic regression (adjusted for gender, age, smoking, and drinking) indicated that CYP2C19 *1/*2, *1/*3, and *2/*2 genotypes may increase susceptibility to hypertension. And the CYP2C19 IM genotype (IM vs. EM: OR 1.514, 95% CI: 1.291–1.775, P < 0.001), PM genotype (PM vs. EM: OR 2.120, 95% CI: 1.638–2.743, P < 0.001), IM + PM genotypes (IM + PM vs. EM: OR 1.617, 95% CI: 1.390–1.882, P < 0.001) may increase risk of hypertension. Conclusions CYP2C19 loss-of-function (IM, PM genotypes) is independent risk factor for hypertension susceptibility. Specifically, the risk genotypes include CYP2C19 *1/*2, *1/*3, and *2/*2. |
| first_indexed | 2024-04-09T18:57:40Z |
| format | Article |
| id | doaj.art-f3b2f575e50d4e42a49d8bcfef0d46ec |
| institution | Directory Open Access Journal |
| issn | 1471-2261 |
| language | English |
| last_indexed | 2024-04-09T18:57:40Z |
| publishDate | 2023-04-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Cardiovascular Disorders |
| spelling | doaj.art-f3b2f575e50d4e42a49d8bcfef0d46ec2023-04-09T11:07:23ZengBMCBMC Cardiovascular Disorders1471-22612023-04-012311810.1186/s12872-023-03207-wCYP2C19 loss-of-function is associated with increased risk of hypertension in a Hakka population: a case-control studyNan Cai0Cunren Li1Xianfang Gu2Wenfeng Zeng3Jiawei Zhong4Jingfeng Liu5Guopeng Zeng6Junxing Zhu7Haifeng Hong8Center for Cardiovascular Diseases, Meizhou People’s Hospital, Meizhou Academy of Medical SciencesCenter for Cardiovascular Diseases, Meizhou People’s Hospital, Meizhou Academy of Medical SciencesCenter for Cardiovascular Diseases, Meizhou People’s Hospital, Meizhou Academy of Medical SciencesCenter for Cardiovascular Diseases, Meizhou People’s Hospital, Meizhou Academy of Medical SciencesCenter for Cardiovascular Diseases, Meizhou People’s Hospital, Meizhou Academy of Medical SciencesCenter for Cardiovascular Diseases, Meizhou People’s Hospital, Meizhou Academy of Medical SciencesCenter for Cardiovascular Diseases, Meizhou People’s Hospital, Meizhou Academy of Medical SciencesCenter for Cardiovascular Diseases, Meizhou People’s Hospital, Meizhou Academy of Medical SciencesCenter for Cardiovascular Diseases, Meizhou People’s Hospital, Meizhou Academy of Medical SciencesAbstract Background Genetic factors have a certain proportion in the risk factors of hypertension. The purpose was to investigate the relationship of cytochrome P450 2C19 (CYP2C19) polymorphisms with hypertension in Hakka population. Methods The study included 1,872 hypertensive patients and 1,110 controls. The genotypes of CYP2C19 rs4244285 and rs4986893 of all individuals were detected and analyzed. Results The genotype and allele distributions of CYP2C19 rs4244285 were significantly different between hypertension group and control group. The CYP2C19 *1/*1 genotype was the most predominant among the subjects (40.8%), followed by the CYP2C19 *1/*2 genotype (40.5%). The percentage of CYP2C19*1, *2, and *3 allele was 64.2%, 30.8%, and 5.0%, respectively. The proportion of intermediate metabolizers (IM) (49.3% vs. 42.9%), poor metabolizers (PM) (14.3% vs. 8.9%) (P < 0.001), and CYP2C19*2 allele (33.8% vs. 25.7%, P < 0.001) in hypertension group was significantly higher than that in control group. Multivariate logistic regression (adjusted for gender, age, smoking, and drinking) indicated that CYP2C19 *1/*2, *1/*3, and *2/*2 genotypes may increase susceptibility to hypertension. And the CYP2C19 IM genotype (IM vs. EM: OR 1.514, 95% CI: 1.291–1.775, P < 0.001), PM genotype (PM vs. EM: OR 2.120, 95% CI: 1.638–2.743, P < 0.001), IM + PM genotypes (IM + PM vs. EM: OR 1.617, 95% CI: 1.390–1.882, P < 0.001) may increase risk of hypertension. Conclusions CYP2C19 loss-of-function (IM, PM genotypes) is independent risk factor for hypertension susceptibility. Specifically, the risk genotypes include CYP2C19 *1/*2, *1/*3, and *2/*2.https://doi.org/10.1186/s12872-023-03207-wCYP2C19PolymorphismHypertensionHakka |
| spellingShingle | Nan Cai Cunren Li Xianfang Gu Wenfeng Zeng Jiawei Zhong Jingfeng Liu Guopeng Zeng Junxing Zhu Haifeng Hong CYP2C19 loss-of-function is associated with increased risk of hypertension in a Hakka population: a case-control study BMC Cardiovascular Disorders CYP2C19 Polymorphism Hypertension Hakka |
| title | CYP2C19 loss-of-function is associated with increased risk of hypertension in a Hakka population: a case-control study |
| title_full | CYP2C19 loss-of-function is associated with increased risk of hypertension in a Hakka population: a case-control study |
| title_fullStr | CYP2C19 loss-of-function is associated with increased risk of hypertension in a Hakka population: a case-control study |
| title_full_unstemmed | CYP2C19 loss-of-function is associated with increased risk of hypertension in a Hakka population: a case-control study |
| title_short | CYP2C19 loss-of-function is associated with increased risk of hypertension in a Hakka population: a case-control study |
| title_sort | cyp2c19 loss of function is associated with increased risk of hypertension in a hakka population a case control study |
| topic | CYP2C19 Polymorphism Hypertension Hakka |
| url | https://doi.org/10.1186/s12872-023-03207-w |
| work_keys_str_mv | AT nancai cyp2c19lossoffunctionisassociatedwithincreasedriskofhypertensioninahakkapopulationacasecontrolstudy AT cunrenli cyp2c19lossoffunctionisassociatedwithincreasedriskofhypertensioninahakkapopulationacasecontrolstudy AT xianfanggu cyp2c19lossoffunctionisassociatedwithincreasedriskofhypertensioninahakkapopulationacasecontrolstudy AT wenfengzeng cyp2c19lossoffunctionisassociatedwithincreasedriskofhypertensioninahakkapopulationacasecontrolstudy AT jiaweizhong cyp2c19lossoffunctionisassociatedwithincreasedriskofhypertensioninahakkapopulationacasecontrolstudy AT jingfengliu cyp2c19lossoffunctionisassociatedwithincreasedriskofhypertensioninahakkapopulationacasecontrolstudy AT guopengzeng cyp2c19lossoffunctionisassociatedwithincreasedriskofhypertensioninahakkapopulationacasecontrolstudy AT junxingzhu cyp2c19lossoffunctionisassociatedwithincreasedriskofhypertensioninahakkapopulationacasecontrolstudy AT haifenghong cyp2c19lossoffunctionisassociatedwithincreasedriskofhypertensioninahakkapopulationacasecontrolstudy |