Association of the Heart Rate Variability Response to Active Standing with the Severity of Calcific Aortic Valve Disease: Novel Insights of a Neurocardiovascular Pathology
The aim of this work was to obtain insights of the participation of the autonomic nervous system in different stages of calcific aortic valve disease (CAVD) by heart rate variability (HRV) analysis. Studying subjects with no valve impairments and CAVD patients, we also sought to quantify the indepen...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-08-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/11/16/4771 |
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| author | Jimena Rodríguez-Carbó José M. Torres-Arellano Nydia Ávila-Vanzzini Rashidi Springall Rafael Bojalil Oscar Infante Claudia Lerma Juan Carlos Echeverría |
| author_facet | Jimena Rodríguez-Carbó José M. Torres-Arellano Nydia Ávila-Vanzzini Rashidi Springall Rafael Bojalil Oscar Infante Claudia Lerma Juan Carlos Echeverría |
| author_sort | Jimena Rodríguez-Carbó |
| collection | DOAJ |
| description | The aim of this work was to obtain insights of the participation of the autonomic nervous system in different stages of calcific aortic valve disease (CAVD) by heart rate variability (HRV) analysis. Studying subjects with no valve impairments and CAVD patients, we also sought to quantify the independent contribution or explanatory capacity of the aortic valve echocardiographic parameters involved in the HRV changes caused by active standing using hierarchical partitioning models to consider other variables or potential confounders. We detected smaller adjustments of the cardiac autonomic response at active standing caused specifically by the aortic valve deterioration. The highest association (i.e., the highest percentage of independent exploratory capacity) was found between the aortic valve area and the active standing changes in the short-term HRV scaling exponent α<sub>1</sub> (4.591%). The valve’s maximum pressure gradient echocardiographic parameter was present in most models assessed (in six out of eight models of HRV indices that included a valve parameter as an independent variable). Overall, our study provides insights with a wider perspective to explore and consider CAVD as a neurocardiovascular pathology. This pathology involves autonomic-driven compensatory mechanisms that seem generated by the aortic valve deterioration. |
| first_indexed | 2024-03-09T04:17:32Z |
| format | Article |
| id | doaj.art-f3b3c2d0f6804ac0b5b6c05a6dd5c491 |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-09T04:17:32Z |
| publishDate | 2022-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-f3b3c2d0f6804ac0b5b6c05a6dd5c4912023-12-03T13:52:37ZengMDPI AGJournal of Clinical Medicine2077-03832022-08-011116477110.3390/jcm11164771Association of the Heart Rate Variability Response to Active Standing with the Severity of Calcific Aortic Valve Disease: Novel Insights of a Neurocardiovascular PathologyJimena Rodríguez-Carbó0José M. Torres-Arellano1Nydia Ávila-Vanzzini2Rashidi Springall3Rafael Bojalil4Oscar Infante5Claudia Lerma6Juan Carlos Echeverría7Posgrado en Ingeniería Biomédica, División de Ciencias Básicas e Ingeniería, Universidad Autónoma Metropolitana, Unidad Iztapalapa, Mexico City 09340, MexicoDepartamento de Instrumentación Electromecánica, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City 14080, MexicoDepartamento de Consulta Externa, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City 14080, MexicoDepartamento de Inmunología, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City 14080, MexicoDepartamento de Atención a la Salud, División de Ciencias Biológicas y de la Salud, Universidad Autónoma Metropolitana, Unidad Xochimilco, Mexico City 04960, MexicoDepartamento de Instrumentación Electromecánica, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City 14080, MexicoDepartamento de Instrumentación Electromecánica, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City 14080, MexicoDepartamento de Ingeniería Eléctrica, División de Ciencias Básicas e Ingeniería, Universidad Autónoma Metropolitana, Unidad Iztapalapa, Mexico City 09340, MexicoThe aim of this work was to obtain insights of the participation of the autonomic nervous system in different stages of calcific aortic valve disease (CAVD) by heart rate variability (HRV) analysis. Studying subjects with no valve impairments and CAVD patients, we also sought to quantify the independent contribution or explanatory capacity of the aortic valve echocardiographic parameters involved in the HRV changes caused by active standing using hierarchical partitioning models to consider other variables or potential confounders. We detected smaller adjustments of the cardiac autonomic response at active standing caused specifically by the aortic valve deterioration. The highest association (i.e., the highest percentage of independent exploratory capacity) was found between the aortic valve area and the active standing changes in the short-term HRV scaling exponent α<sub>1</sub> (4.591%). The valve’s maximum pressure gradient echocardiographic parameter was present in most models assessed (in six out of eight models of HRV indices that included a valve parameter as an independent variable). Overall, our study provides insights with a wider perspective to explore and consider CAVD as a neurocardiovascular pathology. This pathology involves autonomic-driven compensatory mechanisms that seem generated by the aortic valve deterioration.https://www.mdpi.com/2077-0383/11/16/4771calcific aortic valve diseaseheart rate variabilityhierarchical partitioningautonomic nervous systemactive standing |
| spellingShingle | Jimena Rodríguez-Carbó José M. Torres-Arellano Nydia Ávila-Vanzzini Rashidi Springall Rafael Bojalil Oscar Infante Claudia Lerma Juan Carlos Echeverría Association of the Heart Rate Variability Response to Active Standing with the Severity of Calcific Aortic Valve Disease: Novel Insights of a Neurocardiovascular Pathology Journal of Clinical Medicine calcific aortic valve disease heart rate variability hierarchical partitioning autonomic nervous system active standing |
| title | Association of the Heart Rate Variability Response to Active Standing with the Severity of Calcific Aortic Valve Disease: Novel Insights of a Neurocardiovascular Pathology |
| title_full | Association of the Heart Rate Variability Response to Active Standing with the Severity of Calcific Aortic Valve Disease: Novel Insights of a Neurocardiovascular Pathology |
| title_fullStr | Association of the Heart Rate Variability Response to Active Standing with the Severity of Calcific Aortic Valve Disease: Novel Insights of a Neurocardiovascular Pathology |
| title_full_unstemmed | Association of the Heart Rate Variability Response to Active Standing with the Severity of Calcific Aortic Valve Disease: Novel Insights of a Neurocardiovascular Pathology |
| title_short | Association of the Heart Rate Variability Response to Active Standing with the Severity of Calcific Aortic Valve Disease: Novel Insights of a Neurocardiovascular Pathology |
| title_sort | association of the heart rate variability response to active standing with the severity of calcific aortic valve disease novel insights of a neurocardiovascular pathology |
| topic | calcific aortic valve disease heart rate variability hierarchical partitioning autonomic nervous system active standing |
| url | https://www.mdpi.com/2077-0383/11/16/4771 |
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