Ultrasound-triggered piezocatalytic composite hydrogels for promoting bacterial-infected wound healing
Wound healing has become one of the basic issues faced by the medical community because of the susceptibility of skin wounds to bacterial infection. As such, it is highly desired to design a nanocomposite hydrogel with excellent antibacterial activity to achieve high wound closure effectiveness. Her...
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| Format: | Article |
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KeAi Communications Co., Ltd.
2023-06-01
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| Series: | Bioactive Materials |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2452199X2200487X |
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| author | Dun Liu Lei Li Ben-Long Shi Bo Shi Ming-Ding Li Yong Qiu Di Zhao Qun-Dong Shen Ze-Zhang Zhu |
| author_facet | Dun Liu Lei Li Ben-Long Shi Bo Shi Ming-Ding Li Yong Qiu Di Zhao Qun-Dong Shen Ze-Zhang Zhu |
| author_sort | Dun Liu |
| collection | DOAJ |
| description | Wound healing has become one of the basic issues faced by the medical community because of the susceptibility of skin wounds to bacterial infection. As such, it is highly desired to design a nanocomposite hydrogel with excellent antibacterial activity to achieve high wound closure effectiveness. Here, based on ultrasound-triggered piezocatalytic therapy, a multifunctional hydrogel is designed to promote bacteria-infected wound healing. Under ultrasonic vibration, the surface of barium titanate (BaTiO3, BT) nanoparticles embedded in the hydrogel rapidly generate reactive oxygen species (ROS) owing to the established strong built-in electric field, endowing the hydrogel with superior antibacterial efficacy. This modality shows intriguing advantages over conventional photodynamic therapy, such as prominent soft tissue penetration ability and the avoidance of serious skin phototoxicity after systemic administration of photosensitizers. Moreover, the hydrogel based on N-[tris(hydroxymethyl)methyl]acrylamide (THM), N-(3-aminopropyl)methacrylamide hydrochloride (APMH) and oxidized hyaluronic acid (OHA) exhibits outstanding self-healing and bioadhesive properties able to accelerate full-thickness skin wound healing. Notably, compared with the widely reported mussel-inspired adhesive hydrogels, OHA/THM-APMH hydrogel due to the multiple hydrogen bonds from unique tri-hydroxyl structure overcomes the shortage that catechol groups are easily oxidized, giving it long-term and repeatable adhesion performance. Importantly, this hybrid hydrogel confines BT nanoparticles to wound area and locally induced piezoelectric catalysis under ultrasound to eradicate bacteria, markedly improving the therapeutic biosafety and exhibits great potential for harmless treatment of bacteria-infected tissues. |
| first_indexed | 2024-04-09T23:19:08Z |
| format | Article |
| id | doaj.art-f3b429d0792245599807c5631da4058a |
| institution | Directory Open Access Journal |
| issn | 2452-199X |
| language | English |
| last_indexed | 2024-04-09T23:19:08Z |
| publishDate | 2023-06-01 |
| publisher | KeAi Communications Co., Ltd. |
| record_format | Article |
| series | Bioactive Materials |
| spelling | doaj.art-f3b429d0792245599807c5631da4058a2023-03-22T04:37:27ZengKeAi Communications Co., Ltd.Bioactive Materials2452-199X2023-06-012496111Ultrasound-triggered piezocatalytic composite hydrogels for promoting bacterial-infected wound healingDun Liu0Lei Li1Ben-Long Shi2Bo Shi3Ming-Ding Li4Yong Qiu5Di Zhao6Qun-Dong Shen7Ze-Zhang Zhu8Division of Spine Surgery, Department of Orthopedic Surgery, Affiliated Drum Tower Hospital, Medical School of Nanjing University, Nanjing, 210008, ChinaDepartment of Polymer Science and Engineering, Key Laboratory of High-Performance Polymer Materials and Technology of MOE, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, 210023, ChinaDivision of Spine Surgery, Department of Orthopedic Surgery, Affiliated Drum Tower Hospital, Medical School of Nanjing University, Nanjing, 210008, ChinaDivision of Spine Surgery, Department of Orthopedic Surgery, Affiliated Drum Tower Hospital, Medical School of Nanjing University, Nanjing, 210008, ChinaDepartment of Polymer Science and Engineering, Key Laboratory of High-Performance Polymer Materials and Technology of MOE, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, 210023, ChinaDivision of Spine Surgery, Department of Orthopedic Surgery, Affiliated Drum Tower Hospital, Medical School of Nanjing University, Nanjing, 210008, ChinaInstitute of Brain Science and Disease, School of Basic Medicine, Qingdao University, Qingdao, Shandong, 266001, China; Corresponding author.Department of Polymer Science and Engineering, Key Laboratory of High-Performance Polymer Materials and Technology of MOE, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, 210023, China; Corresponding author.Division of Spine Surgery, Department of Orthopedic Surgery, Affiliated Drum Tower Hospital, Medical School of Nanjing University, Nanjing, 210008, China; Corresponding author. Division of Spine Surgery, Department of Orthopedic Surgery, Affiliated Drum Tower Hospital, Medical School of Nanjing University, Nanjing, 210008, China.Wound healing has become one of the basic issues faced by the medical community because of the susceptibility of skin wounds to bacterial infection. As such, it is highly desired to design a nanocomposite hydrogel with excellent antibacterial activity to achieve high wound closure effectiveness. Here, based on ultrasound-triggered piezocatalytic therapy, a multifunctional hydrogel is designed to promote bacteria-infected wound healing. Under ultrasonic vibration, the surface of barium titanate (BaTiO3, BT) nanoparticles embedded in the hydrogel rapidly generate reactive oxygen species (ROS) owing to the established strong built-in electric field, endowing the hydrogel with superior antibacterial efficacy. This modality shows intriguing advantages over conventional photodynamic therapy, such as prominent soft tissue penetration ability and the avoidance of serious skin phototoxicity after systemic administration of photosensitizers. Moreover, the hydrogel based on N-[tris(hydroxymethyl)methyl]acrylamide (THM), N-(3-aminopropyl)methacrylamide hydrochloride (APMH) and oxidized hyaluronic acid (OHA) exhibits outstanding self-healing and bioadhesive properties able to accelerate full-thickness skin wound healing. Notably, compared with the widely reported mussel-inspired adhesive hydrogels, OHA/THM-APMH hydrogel due to the multiple hydrogen bonds from unique tri-hydroxyl structure overcomes the shortage that catechol groups are easily oxidized, giving it long-term and repeatable adhesion performance. Importantly, this hybrid hydrogel confines BT nanoparticles to wound area and locally induced piezoelectric catalysis under ultrasound to eradicate bacteria, markedly improving the therapeutic biosafety and exhibits great potential for harmless treatment of bacteria-infected tissues.http://www.sciencedirect.com/science/article/pii/S2452199X2200487XMultifunctional hydrogelsBioadhesivenessSelf-healingAntibacterial abilityPiezocatalytic therapy |
| spellingShingle | Dun Liu Lei Li Ben-Long Shi Bo Shi Ming-Ding Li Yong Qiu Di Zhao Qun-Dong Shen Ze-Zhang Zhu Ultrasound-triggered piezocatalytic composite hydrogels for promoting bacterial-infected wound healing Bioactive Materials Multifunctional hydrogels Bioadhesiveness Self-healing Antibacterial ability Piezocatalytic therapy |
| title | Ultrasound-triggered piezocatalytic composite hydrogels for promoting bacterial-infected wound healing |
| title_full | Ultrasound-triggered piezocatalytic composite hydrogels for promoting bacterial-infected wound healing |
| title_fullStr | Ultrasound-triggered piezocatalytic composite hydrogels for promoting bacterial-infected wound healing |
| title_full_unstemmed | Ultrasound-triggered piezocatalytic composite hydrogels for promoting bacterial-infected wound healing |
| title_short | Ultrasound-triggered piezocatalytic composite hydrogels for promoting bacterial-infected wound healing |
| title_sort | ultrasound triggered piezocatalytic composite hydrogels for promoting bacterial infected wound healing |
| topic | Multifunctional hydrogels Bioadhesiveness Self-healing Antibacterial ability Piezocatalytic therapy |
| url | http://www.sciencedirect.com/science/article/pii/S2452199X2200487X |
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