Protective Role of Vitamin D in Renal Tubulopathies
Vitamin D is tightly linked with renal tubular homeostasis: the mitochondria of proximal convoluted tubule cells are the production site of 1α,25-dihydroxyvitamin D3. Patients with renal impairment or tubular injury often suffer from chronic inflammation. This alteration comes from oxidativ...
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| Format: | Article |
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MDPI AG
2020-03-01
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| Series: | Metabolites |
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| Online Access: | https://www.mdpi.com/2218-1989/10/3/115 |
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| author | Guido Gembillo Valeria Cernaro Rossella Siligato Francesco Curreri Antonino Catalano Domenico Santoro |
| author_facet | Guido Gembillo Valeria Cernaro Rossella Siligato Francesco Curreri Antonino Catalano Domenico Santoro |
| author_sort | Guido Gembillo |
| collection | DOAJ |
| description | Vitamin D is tightly linked with renal tubular homeostasis: the mitochondria of proximal convoluted tubule cells are the production site of 1α,25-dihydroxyvitamin D3. Patients with renal impairment or tubular injury often suffer from chronic inflammation. This alteration comes from oxidative stress, acidosis, decreased clearance of inflammatory cytokines and stimulation of inflammatory factors. The challenge is to find the right formula for each patient to correctly modulate the landscape of treatment and preserve the essential functions of the organism without perturbating its homeostasis. The complexity of the counter-regulation mechanisms and the different axis involved in the Vitamin D equilibrium pose a major issue on Vitamin D as a potential effective anti-inflammatory drug. The therapeutic use of this compound should be able to inhibit the development of inflammation without interfering with normal homeostasis. Megalin-Cubilin-Amnionless and the FGF23-Klotho axis represent two Vitamin D-linked mechanisms that could modulate and ameliorate the damage response at the renal tubular level, balancing Vitamin D therapy with an effect potent enough to contrast the inflammatory cascades, but which avoids potential severe side effects. |
| first_indexed | 2024-12-11T09:06:07Z |
| format | Article |
| id | doaj.art-f3b7e4d81af0470e9ebd1f171110d6a0 |
| institution | Directory Open Access Journal |
| issn | 2218-1989 |
| language | English |
| last_indexed | 2024-12-11T09:06:07Z |
| publishDate | 2020-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Metabolites |
| spelling | doaj.art-f3b7e4d81af0470e9ebd1f171110d6a02022-12-22T01:13:38ZengMDPI AGMetabolites2218-19892020-03-0110311510.3390/metabo10030115metabo10030115Protective Role of Vitamin D in Renal TubulopathiesGuido Gembillo0Valeria Cernaro1Rossella Siligato2Francesco Curreri3Antonino Catalano4Domenico Santoro5Unit of Nephrology and Dialysis, Department of Clinical and Experimental Medicine, University of Messina, Via Consolare Valeria, 98125 Messina, ItalyUnit of Nephrology and Dialysis, Department of Clinical and Experimental Medicine, University of Messina, Via Consolare Valeria, 98125 Messina, ItalyUnit of Nephrology and Dialysis, Department of Clinical and Experimental Medicine, University of Messina, Via Consolare Valeria, 98125 Messina, ItalyMIFT, University of Messina, 98125 Messina, ItalyDepartment of Clinical and Experimental Medicine, University of Messina, 98125 Messina, ItalyUnit of Nephrology and Dialysis, Department of Clinical and Experimental Medicine, University of Messina, Via Consolare Valeria, 98125 Messina, ItalyVitamin D is tightly linked with renal tubular homeostasis: the mitochondria of proximal convoluted tubule cells are the production site of 1α,25-dihydroxyvitamin D3. Patients with renal impairment or tubular injury often suffer from chronic inflammation. This alteration comes from oxidative stress, acidosis, decreased clearance of inflammatory cytokines and stimulation of inflammatory factors. The challenge is to find the right formula for each patient to correctly modulate the landscape of treatment and preserve the essential functions of the organism without perturbating its homeostasis. The complexity of the counter-regulation mechanisms and the different axis involved in the Vitamin D equilibrium pose a major issue on Vitamin D as a potential effective anti-inflammatory drug. The therapeutic use of this compound should be able to inhibit the development of inflammation without interfering with normal homeostasis. Megalin-Cubilin-Amnionless and the FGF23-Klotho axis represent two Vitamin D-linked mechanisms that could modulate and ameliorate the damage response at the renal tubular level, balancing Vitamin D therapy with an effect potent enough to contrast the inflammatory cascades, but which avoids potential severe side effects.https://www.mdpi.com/2218-1989/10/3/115vitamin dtubulopathiestubular injurymegalincubilinfgf23klothocalcitriolckdvdr |
| spellingShingle | Guido Gembillo Valeria Cernaro Rossella Siligato Francesco Curreri Antonino Catalano Domenico Santoro Protective Role of Vitamin D in Renal Tubulopathies Metabolites vitamin d tubulopathies tubular injury megalin cubilin fgf23 klotho calcitriol ckd vdr |
| title | Protective Role of Vitamin D in Renal Tubulopathies |
| title_full | Protective Role of Vitamin D in Renal Tubulopathies |
| title_fullStr | Protective Role of Vitamin D in Renal Tubulopathies |
| title_full_unstemmed | Protective Role of Vitamin D in Renal Tubulopathies |
| title_short | Protective Role of Vitamin D in Renal Tubulopathies |
| title_sort | protective role of vitamin d in renal tubulopathies |
| topic | vitamin d tubulopathies tubular injury megalin cubilin fgf23 klotho calcitriol ckd vdr |
| url | https://www.mdpi.com/2218-1989/10/3/115 |
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