Ultrasensitive Detection of Testosterone Using Microring Resonator with Molecularly Imprinted Polymers
We report ultrasensitive and highly selective detection of testosterone based on microring resonance sensor using molecularly imprinted polymers (MIP). A silicon-on-insulator (SOI) micoring resonator was modified by MIP films (MIPs) on a surface. The MIPs was synthesized by thermopolymerization usin...
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| Format: | Article |
| Language: | English |
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MDPI AG
2015-12-01
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| Series: | Sensors |
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| Online Access: | http://www.mdpi.com/1424-8220/15/12/29877 |
| _version_ | 1818040685150863360 |
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| author | Yangqing Chen Yong Liu Xiaodan Shen Zhimin Chang Longhua Tang Wen-Fei Dong Mingyu Li Jian-Jun He |
| author_facet | Yangqing Chen Yong Liu Xiaodan Shen Zhimin Chang Longhua Tang Wen-Fei Dong Mingyu Li Jian-Jun He |
| author_sort | Yangqing Chen |
| collection | DOAJ |
| description | We report ultrasensitive and highly selective detection of testosterone based on microring resonance sensor using molecularly imprinted polymers (MIP). A silicon-on-insulator (SOI) micoring resonator was modified by MIP films (MIPs) on a surface. The MIPs was synthesized by thermopolymerization using methacrylic acid as functional monomer and ethylene glycol dimethacrylate as crosslinking agent. The concentration of detected testosterone varies from 0.05 ng/mL to 10 ng/mL. The detection limit reaches 48.7 pg/mL. Ultrahigh sensitivity, good specificity and reproducibility have been demonstrated, indicating the great potential of making a cost effective and easy to operate lab-on-Chip and down scaling micro-fluidics devices in biosensing. |
| first_indexed | 2024-12-10T08:18:27Z |
| format | Article |
| id | doaj.art-f3b90b725a5449f396721871e9079798 |
| institution | Directory Open Access Journal |
| issn | 1424-8220 |
| language | English |
| last_indexed | 2024-12-10T08:18:27Z |
| publishDate | 2015-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Sensors |
| spelling | doaj.art-f3b90b725a5449f396721871e90797982022-12-22T01:56:25ZengMDPI AGSensors1424-82202015-12-011512315583156510.3390/s151229877s151229877Ultrasensitive Detection of Testosterone Using Microring Resonator with Molecularly Imprinted PolymersYangqing Chen0Yong Liu1Xiaodan Shen2Zhimin Chang3Longhua Tang4Wen-Fei Dong5Mingyu Li6Jian-Jun He7State Key Laboratory of Modern Optical Instrumentation, Zhejiang University, Hangzhou 310027, Zhejiang, ChinaState Key Laboratory of Modern Optical Instrumentation, Zhejiang University, Hangzhou 310027, Zhejiang, ChinaState Key Laboratory of Modern Optical Instrumentation, Zhejiang University, Hangzhou 310027, Zhejiang, ChinaCAS Key Lab of Bio-Medical Diagnostics, Suzhou Institute of Biomedical Engineering and Technology, Chinese Academy of Sciences, Suzhou 215163, Jiangsu, ChinaState Key Laboratory of Modern Optical Instrumentation, Zhejiang University, Hangzhou 310027, Zhejiang, ChinaCAS Key Lab of Bio-Medical Diagnostics, Suzhou Institute of Biomedical Engineering and Technology, Chinese Academy of Sciences, Suzhou 215163, Jiangsu, ChinaState Key Laboratory of Modern Optical Instrumentation, Zhejiang University, Hangzhou 310027, Zhejiang, ChinaState Key Laboratory of Modern Optical Instrumentation, Zhejiang University, Hangzhou 310027, Zhejiang, ChinaWe report ultrasensitive and highly selective detection of testosterone based on microring resonance sensor using molecularly imprinted polymers (MIP). A silicon-on-insulator (SOI) micoring resonator was modified by MIP films (MIPs) on a surface. The MIPs was synthesized by thermopolymerization using methacrylic acid as functional monomer and ethylene glycol dimethacrylate as crosslinking agent. The concentration of detected testosterone varies from 0.05 ng/mL to 10 ng/mL. The detection limit reaches 48.7 pg/mL. Ultrahigh sensitivity, good specificity and reproducibility have been demonstrated, indicating the great potential of making a cost effective and easy to operate lab-on-Chip and down scaling micro-fluidics devices in biosensing.http://www.mdpi.com/1424-8220/15/12/29877Microring resonatorMolecularly imprinted polymersTestosterone |
| spellingShingle | Yangqing Chen Yong Liu Xiaodan Shen Zhimin Chang Longhua Tang Wen-Fei Dong Mingyu Li Jian-Jun He Ultrasensitive Detection of Testosterone Using Microring Resonator with Molecularly Imprinted Polymers Sensors Microring resonator Molecularly imprinted polymers Testosterone |
| title | Ultrasensitive Detection of Testosterone Using Microring Resonator with Molecularly Imprinted Polymers |
| title_full | Ultrasensitive Detection of Testosterone Using Microring Resonator with Molecularly Imprinted Polymers |
| title_fullStr | Ultrasensitive Detection of Testosterone Using Microring Resonator with Molecularly Imprinted Polymers |
| title_full_unstemmed | Ultrasensitive Detection of Testosterone Using Microring Resonator with Molecularly Imprinted Polymers |
| title_short | Ultrasensitive Detection of Testosterone Using Microring Resonator with Molecularly Imprinted Polymers |
| title_sort | ultrasensitive detection of testosterone using microring resonator with molecularly imprinted polymers |
| topic | Microring resonator Molecularly imprinted polymers Testosterone |
| url | http://www.mdpi.com/1424-8220/15/12/29877 |
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