Mycobacteriosis in the compromised host
The studies of rare genetic defects, the preliminary results of population-based studies, being validated by the experimental immunocompromised animal models and the current observations accumulated in immunocompromised patients with mycobacterial diseases provide us with insights into the importanc...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Fundação Oswaldo Cruz (FIOCRUZ)
2000-01-01
|
| Series: | Memorias do Instituto Oswaldo Cruz |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762000000700027 |
| _version_ | 1797758540007342080 |
|---|---|
| author | PH Lagrange A Wargnier JL Herrmann |
| author_facet | PH Lagrange A Wargnier JL Herrmann |
| author_sort | PH Lagrange |
| collection | DOAJ |
| description | The studies of rare genetic defects, the preliminary results of population-based studies, being validated by the experimental immunocompromised animal models and the current observations accumulated in immunocompromised patients with mycobacterial diseases provide us with insights into the importance of the macrophage activation pathway in controlling human infection with pathogenic and non pathogenic intracellular multiplying mycobacteria. Initial cytokine production by infected macrophages and/or dendritic cells could be crucial in the overall regulation of self cure, acquired protection or immunopathological sequelae expressing the disease. Knowledge of molecular and genetic cross-talks between phagocytic and specialized antigen presenting cells and different mycobacterial products associated with persistence or replication of the intracellular bacteria, could provide further informations on the global immune regulation of the early host responses to infection and the following events. It seems likely that the development of mycobacterial infections in humans will turn out to be as much dependent on the genetic make up of the host as or the virulence of the bacteria. |
| first_indexed | 2024-03-12T18:31:28Z |
| format | Article |
| id | doaj.art-f3b9c16f7d84473db3a0513d007d9ee9 |
| institution | Directory Open Access Journal |
| issn | 0074-0276 1678-8060 |
| language | English |
| last_indexed | 2024-03-12T18:31:28Z |
| publishDate | 2000-01-01 |
| publisher | Fundação Oswaldo Cruz (FIOCRUZ) |
| record_format | Article |
| series | Memorias do Instituto Oswaldo Cruz |
| spelling | doaj.art-f3b9c16f7d84473db3a0513d007d9ee92023-08-02T08:19:08ZengFundação Oswaldo Cruz (FIOCRUZ)Memorias do Instituto Oswaldo Cruz0074-02761678-80602000-01-019516317010.1590/S0074-02762000000700027Mycobacteriosis in the compromised hostPH LagrangeA WargnierJL HerrmannThe studies of rare genetic defects, the preliminary results of population-based studies, being validated by the experimental immunocompromised animal models and the current observations accumulated in immunocompromised patients with mycobacterial diseases provide us with insights into the importance of the macrophage activation pathway in controlling human infection with pathogenic and non pathogenic intracellular multiplying mycobacteria. Initial cytokine production by infected macrophages and/or dendritic cells could be crucial in the overall regulation of self cure, acquired protection or immunopathological sequelae expressing the disease. Knowledge of molecular and genetic cross-talks between phagocytic and specialized antigen presenting cells and different mycobacterial products associated with persistence or replication of the intracellular bacteria, could provide further informations on the global immune regulation of the early host responses to infection and the following events. It seems likely that the development of mycobacterial infections in humans will turn out to be as much dependent on the genetic make up of the host as or the virulence of the bacteria.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762000000700027tuberculosisacquired immunodeficiency syndrome-Aidsatypical mycobacteriaknockout mouse |
| spellingShingle | PH Lagrange A Wargnier JL Herrmann Mycobacteriosis in the compromised host Memorias do Instituto Oswaldo Cruz tuberculosis acquired immunodeficiency syndrome-Aids atypical mycobacteria knockout mouse |
| title | Mycobacteriosis in the compromised host |
| title_full | Mycobacteriosis in the compromised host |
| title_fullStr | Mycobacteriosis in the compromised host |
| title_full_unstemmed | Mycobacteriosis in the compromised host |
| title_short | Mycobacteriosis in the compromised host |
| title_sort | mycobacteriosis in the compromised host |
| topic | tuberculosis acquired immunodeficiency syndrome-Aids atypical mycobacteria knockout mouse |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762000000700027 |
| work_keys_str_mv | AT phlagrange mycobacteriosisinthecompromisedhost AT awargnier mycobacteriosisinthecompromisedhost AT jlherrmann mycobacteriosisinthecompromisedhost |