Practical considerations for a TB controlled human infection model (TB-CHIM); the case for TB-CHIM in Africa, a systematic review of the literature and report of 2 workshop discussions in UK and Malawi [version 1; peer review: 2 approved, 1 approved with reservations]

Practical considerations for a TB controlled human infection model (TB-CHIM); the case for TB-CHIM in Africa, a systematic review of the literature and report of 2 workshop discussions in UK and Malawi [version 1; peer review: 2 approved, 1 approved with reservations]

Background: Tuberculosis (TB) remains a major challenge in many domains including diagnosis, pathogenesis, prevention, treatment, drug resistance and long-term protection of the public health by vaccination. A controlled human infection model (CHIM) could potentially facilitate breakthroughs in each...

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Bibliographic Details
Main Authors: Keertan Dedha, Henry Mwandumba, Brian D. Robertson, Nimisha Raj Sharma, Naomi Walker, Simon Sichone, Shobana Balasingam, Ben Morton, Stephen B. Gordon, Phoebe Hazenberg, Kondwani Jambo, Anthony E. Chirwa, Joanne Flynn, Zacharia Kafuko, Daniela M. Ferreira, Giancarlo A. Biagini, Sarah Fortune, Helen McShane
Format: Article
Language:English
Published: Wellcome 2023-02-01
Series:Wellcome Open Research
Subjects:
Human infection studies
tuberculosis
TB
BCG
bacille Calmette Guerin
vaccine
eng
Online Access:https://wellcomeopenresearch.org/articles/8-71/v1

Internet

https://wellcomeopenresearch.org/articles/8-71/v1

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