Retroperitoneal Lymph Node Dissection in Colorectal Cancer with Lymph Node Metastasis: A Systematic Review
The benefits and prognosis of RPLND in CRC have not yet been fully established. This systematic review aimed to evaluate the outcomes for CRC patients with RPLNM undergoing RPLND. A literature search of MEDLINE, EMBASE, EMCare, and CINAHL identified studies from between January 1990 and June 2022 th...
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MDPI AG
2023-01-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/15/2/455 |
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| author | Michael G. Fadel Mosab Ahmed Gianluca Pellino Shahnawaz Rasheed Paris Tekkis David Nicol Christos Kontovounisios Erik Mayer |
| author_facet | Michael G. Fadel Mosab Ahmed Gianluca Pellino Shahnawaz Rasheed Paris Tekkis David Nicol Christos Kontovounisios Erik Mayer |
| author_sort | Michael G. Fadel |
| collection | DOAJ |
| description | The benefits and prognosis of RPLND in CRC have not yet been fully established. This systematic review aimed to evaluate the outcomes for CRC patients with RPLNM undergoing RPLND. A literature search of MEDLINE, EMBASE, EMCare, and CINAHL identified studies from between January 1990 and June 2022 that reported data on clinical outcomes for patients who underwent RPLND for RPLNM in CRC. The following primary outcome measures were derived: postoperative morbidity, disease free-survival (DFS), overall survival (OS), and re-recurrence. Nineteen studies with a total of 541 patients were included. Three hundred and sixty-three patients (67.1%) had synchronous RPLNM and 178 patients (32.9%) had metachronous RPLNM. Perioperative chemotherapy was administered in 496 (91.7%) patients. The median DFS was 8.6–38.0 months and 5-year DFS was 24.4% (10.0–60.5%). The median OS was 25.0–83.0 months and 5-year OS was 47.0% (15.0–87.5%). RPLND is a feasible treatment option with limited morbidity and possible oncological benefit for both synchronous and metachronous RPLNM in CRC. Further prospective clinical trials are required to establish a better evidence base for RPLND in the context of RPLNM in CRC and to understand the timing of RPLND in a multimodality pathway in order to optimise treatment outcomes for this group of patients. |
| first_indexed | 2024-03-09T13:18:00Z |
| format | Article |
| id | doaj.art-f3bb0fb39a1e4451b3e653ae098f3bb9 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-09T13:18:00Z |
| publishDate | 2023-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-f3bb0fb39a1e4451b3e653ae098f3bb92023-11-30T21:34:07ZengMDPI AGCancers2072-66942023-01-0115245510.3390/cancers15020455Retroperitoneal Lymph Node Dissection in Colorectal Cancer with Lymph Node Metastasis: A Systematic ReviewMichael G. Fadel0Mosab Ahmed1Gianluca Pellino2Shahnawaz Rasheed3Paris Tekkis4David Nicol5Christos Kontovounisios6Erik Mayer7Department of Surgery and Cancer, Imperial College London, London SW7 2AZ, UKDepartment of Colorectal Surgery, Chelsea and Westminster Hospital NHS Foundation Trust, London SW10 9NH, UKDepartment of Advanced Medical and Surgical Sciences, University of Campania “Luigi Vanvitelli”, 80138 Naples, ItalyDepartment of Surgery and Cancer, Imperial College London, London SW7 2AZ, UKDepartment of Surgery and Cancer, Imperial College London, London SW7 2AZ, UKDepartment of Academic Urology, Royal Marsden NHS Foundation Trust, London SW3 6JJ, UKDepartment of Surgery and Cancer, Imperial College London, London SW7 2AZ, UKDepartment of Surgery and Cancer, Imperial College London, London SW7 2AZ, UKThe benefits and prognosis of RPLND in CRC have not yet been fully established. This systematic review aimed to evaluate the outcomes for CRC patients with RPLNM undergoing RPLND. A literature search of MEDLINE, EMBASE, EMCare, and CINAHL identified studies from between January 1990 and June 2022 that reported data on clinical outcomes for patients who underwent RPLND for RPLNM in CRC. The following primary outcome measures were derived: postoperative morbidity, disease free-survival (DFS), overall survival (OS), and re-recurrence. Nineteen studies with a total of 541 patients were included. Three hundred and sixty-three patients (67.1%) had synchronous RPLNM and 178 patients (32.9%) had metachronous RPLNM. Perioperative chemotherapy was administered in 496 (91.7%) patients. The median DFS was 8.6–38.0 months and 5-year DFS was 24.4% (10.0–60.5%). The median OS was 25.0–83.0 months and 5-year OS was 47.0% (15.0–87.5%). RPLND is a feasible treatment option with limited morbidity and possible oncological benefit for both synchronous and metachronous RPLNM in CRC. Further prospective clinical trials are required to establish a better evidence base for RPLND in the context of RPLNM in CRC and to understand the timing of RPLND in a multimodality pathway in order to optimise treatment outcomes for this group of patients.https://www.mdpi.com/2072-6694/15/2/455lymph node dissectioncolorectal cancermetastasisdisease-free survivalrecurrence |
| spellingShingle | Michael G. Fadel Mosab Ahmed Gianluca Pellino Shahnawaz Rasheed Paris Tekkis David Nicol Christos Kontovounisios Erik Mayer Retroperitoneal Lymph Node Dissection in Colorectal Cancer with Lymph Node Metastasis: A Systematic Review Cancers lymph node dissection colorectal cancer metastasis disease-free survival recurrence |
| title | Retroperitoneal Lymph Node Dissection in Colorectal Cancer with Lymph Node Metastasis: A Systematic Review |
| title_full | Retroperitoneal Lymph Node Dissection in Colorectal Cancer with Lymph Node Metastasis: A Systematic Review |
| title_fullStr | Retroperitoneal Lymph Node Dissection in Colorectal Cancer with Lymph Node Metastasis: A Systematic Review |
| title_full_unstemmed | Retroperitoneal Lymph Node Dissection in Colorectal Cancer with Lymph Node Metastasis: A Systematic Review |
| title_short | Retroperitoneal Lymph Node Dissection in Colorectal Cancer with Lymph Node Metastasis: A Systematic Review |
| title_sort | retroperitoneal lymph node dissection in colorectal cancer with lymph node metastasis a systematic review |
| topic | lymph node dissection colorectal cancer metastasis disease-free survival recurrence |
| url | https://www.mdpi.com/2072-6694/15/2/455 |
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