Serotonin Improves High Fat Diet Induced Obesity in Mice.
There are two independent serotonin (5-HT) systems of organization: one in the central nervous system and the other in the periphery. 5-HT affects feeding behavior and obesity in the central nervous system. On the other hand, peripheral 5-HT also may play an important role in obesity, as it has been...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2016-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC4713156?pdf=render |
| _version_ | 1818387623903756288 |
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| author | Hitoshi Watanabe Tatsuya Nakano Ryo Saito Daisuke Akasaka Kazuki Saito Hideki Ogasawara Takeshi Minashima Kohtaro Miyazawa Takashi Kanaya Ikuro Takakura Nao Inoue Ikuo Ikeda Xiangning Chen Masato Miyake Haruki Kitazawa Hitoshi Shirakawa Kan Sato Kohji Tahara Yuya Nagasawa Michael T Rose Shyuichi Ohwada Kouichi Watanabe Hisashi Aso |
| author_facet | Hitoshi Watanabe Tatsuya Nakano Ryo Saito Daisuke Akasaka Kazuki Saito Hideki Ogasawara Takeshi Minashima Kohtaro Miyazawa Takashi Kanaya Ikuro Takakura Nao Inoue Ikuo Ikeda Xiangning Chen Masato Miyake Haruki Kitazawa Hitoshi Shirakawa Kan Sato Kohji Tahara Yuya Nagasawa Michael T Rose Shyuichi Ohwada Kouichi Watanabe Hisashi Aso |
| author_sort | Hitoshi Watanabe |
| collection | DOAJ |
| description | There are two independent serotonin (5-HT) systems of organization: one in the central nervous system and the other in the periphery. 5-HT affects feeding behavior and obesity in the central nervous system. On the other hand, peripheral 5-HT also may play an important role in obesity, as it has been reported that 5-HT regulates glucose and lipid metabolism. Here we show that the intraperitoneal injection of 5-HT to mice inhibits weight gain, hyperglycemia and insulin resistance and completely prevented the enlargement of intra-abdominal adipocytes without having any effect on food intake when on a high fat diet, but not on a chow diet. 5-HT increased energy expenditure, O2 consumption and CO2 production. This novel metabolic effect of peripheral 5-HT is critically related to a shift in the profile of muscle fiber type from fast/glycolytic to slow/oxidative in soleus muscle. Additionally, 5-HT dramatically induced an increase in the mRNA expression of peroxisome proliferator-activated receptor coactivator 1α (PGC-1α)-b and PGC-1α-c in soleus muscle. The elevation of these gene mRNA expressions by 5-HT injection was inhibited by treatment with 5-HT receptor (5HTR) 2A or 7 antagonists. Our results demonstrate that peripheral 5-HT may play an important role in the relief of obesity and other metabolic disorders by accelerating energy consumption in skeletal muscle. |
| first_indexed | 2024-12-14T04:12:54Z |
| format | Article |
| id | doaj.art-f3bb1728734e4833ac242942d4f00810 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-14T04:12:54Z |
| publishDate | 2016-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-f3bb1728734e4833ac242942d4f008102022-12-21T23:17:37ZengPublic Library of Science (PLoS)PLoS ONE1932-62032016-01-01111e014714310.1371/journal.pone.0147143Serotonin Improves High Fat Diet Induced Obesity in Mice.Hitoshi WatanabeTatsuya NakanoRyo SaitoDaisuke AkasakaKazuki SaitoHideki OgasawaraTakeshi MinashimaKohtaro MiyazawaTakashi KanayaIkuro TakakuraNao InoueIkuo IkedaXiangning ChenMasato MiyakeHaruki KitazawaHitoshi ShirakawaKan SatoKohji TaharaYuya NagasawaMichael T RoseShyuichi OhwadaKouichi WatanabeHisashi AsoThere are two independent serotonin (5-HT) systems of organization: one in the central nervous system and the other in the periphery. 5-HT affects feeding behavior and obesity in the central nervous system. On the other hand, peripheral 5-HT also may play an important role in obesity, as it has been reported that 5-HT regulates glucose and lipid metabolism. Here we show that the intraperitoneal injection of 5-HT to mice inhibits weight gain, hyperglycemia and insulin resistance and completely prevented the enlargement of intra-abdominal adipocytes without having any effect on food intake when on a high fat diet, but not on a chow diet. 5-HT increased energy expenditure, O2 consumption and CO2 production. This novel metabolic effect of peripheral 5-HT is critically related to a shift in the profile of muscle fiber type from fast/glycolytic to slow/oxidative in soleus muscle. Additionally, 5-HT dramatically induced an increase in the mRNA expression of peroxisome proliferator-activated receptor coactivator 1α (PGC-1α)-b and PGC-1α-c in soleus muscle. The elevation of these gene mRNA expressions by 5-HT injection was inhibited by treatment with 5-HT receptor (5HTR) 2A or 7 antagonists. Our results demonstrate that peripheral 5-HT may play an important role in the relief of obesity and other metabolic disorders by accelerating energy consumption in skeletal muscle.http://europepmc.org/articles/PMC4713156?pdf=render |
| spellingShingle | Hitoshi Watanabe Tatsuya Nakano Ryo Saito Daisuke Akasaka Kazuki Saito Hideki Ogasawara Takeshi Minashima Kohtaro Miyazawa Takashi Kanaya Ikuro Takakura Nao Inoue Ikuo Ikeda Xiangning Chen Masato Miyake Haruki Kitazawa Hitoshi Shirakawa Kan Sato Kohji Tahara Yuya Nagasawa Michael T Rose Shyuichi Ohwada Kouichi Watanabe Hisashi Aso Serotonin Improves High Fat Diet Induced Obesity in Mice. PLoS ONE |
| title | Serotonin Improves High Fat Diet Induced Obesity in Mice. |
| title_full | Serotonin Improves High Fat Diet Induced Obesity in Mice. |
| title_fullStr | Serotonin Improves High Fat Diet Induced Obesity in Mice. |
| title_full_unstemmed | Serotonin Improves High Fat Diet Induced Obesity in Mice. |
| title_short | Serotonin Improves High Fat Diet Induced Obesity in Mice. |
| title_sort | serotonin improves high fat diet induced obesity in mice |
| url | http://europepmc.org/articles/PMC4713156?pdf=render |
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