Characterization of norbelladine synthase and noroxomaritidine/norcraugsodine reductase reveals a novel catalytic route for the biosynthesis of Amaryllidaceae alkaloids including the Alzheimer’s drug galanthamine

Characterization of norbelladine synthase and noroxomaritidine/norcraugsodine reductase reveals a novel catalytic route for the biosynthesis of Amaryllidaceae alkaloids including the Alzheimer’s drug galanthamine

Amaryllidaceae alkaloids (AAs) are a large group of plant specialized metabolites with diverse pharmacological properties. Norbelladine is the entry compound in AAs biosynthesis and is produced from the condensation of tyramine and 3,4-dihydroxybenzaldehyde (3,4-DHBA). There are two reported enzymes...

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Bibliographic Details
Main Authors: Bharat Bhusan Majhi, Sarah-Eve Gélinas, Natacha Mérindol, Simon Ricard, Isabel Desgagné-Penix
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-08-01
Series:Frontiers in Plant Science
Subjects:
Amaryllidaceae alkaloids
Leucojum aestivum
Narcissus papyraceus
norbelladine synthase
noroxomaritidine/norcraugsodine reductase
enzyme activity
Online Access:https://www.frontiersin.org/articles/10.3389/fpls.2023.1231809/full

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