Biomembrane-wrapped gene delivery nanoparticles for cancer therapy
As a promising strategy, gene delivery for cancer treatment accepts encouraging progress due to its high efficacy, low toxicity, and exclusive selectivity. However, the delivery efficiency, specific biological distribution, targeted uptake, and biosafety of naked nucleic acid agents still face serio...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-06-01
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| Series: | Frontiers in Bioengineering and Biotechnology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fbioe.2023.1211753/full |
| _version_ | 1797809884379480064 |
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| author | Jie Li Jie Li Huamin Zeng Luwei Li Ming Song Mingqing Dong Mingqing Dong |
| author_facet | Jie Li Jie Li Huamin Zeng Luwei Li Ming Song Mingqing Dong Mingqing Dong |
| author_sort | Jie Li |
| collection | DOAJ |
| description | As a promising strategy, gene delivery for cancer treatment accepts encouraging progress due to its high efficacy, low toxicity, and exclusive selectivity. However, the delivery efficiency, specific biological distribution, targeted uptake, and biosafety of naked nucleic acid agents still face serious challenges, which limit further clinical application. To overcome the above bottleneck, safe and efficient functional nanovectors are developed to improve the delivery efficiency of nucleic acid agents. In recent years, emerging membrane-wrapped biomimetic nanoparticles (MBNPs) based on the concept of “imitating nature” are well known for their advantages, such as low immunogenicity and long cycle time, and especially play a crucial role in improving the overall efficiency of gene delivery and reducing adverse reactions. Therefore, combining MBNPs and gene delivery is an effective strategy to enhance tumor treatment efficiency. This review presents the mechanism of gene therapy and the current obstacles to gene delivery. Remarkably, the latest development of gene delivery MBNPs and the strategies to overcome these obstacles are summarized. Finally, the future challenges and prospects of gene delivery MBNPs toward clinical transformation are introduced. The principal purpose of this review is to discuss the biomedical potential of gene delivery MBNPs for cancer therapy and to provide guidance for further enhancing the efficiency of tumor gene therapy. |
| first_indexed | 2024-03-13T07:00:40Z |
| format | Article |
| id | doaj.art-f3bbcf51fcf3420cb71ece825fdd9781 |
| institution | Directory Open Access Journal |
| issn | 2296-4185 |
| language | English |
| last_indexed | 2024-03-13T07:00:40Z |
| publishDate | 2023-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Bioengineering and Biotechnology |
| spelling | doaj.art-f3bbcf51fcf3420cb71ece825fdd97812023-06-07T04:42:10ZengFrontiers Media S.A.Frontiers in Bioengineering and Biotechnology2296-41852023-06-011110.3389/fbioe.2023.12117531211753Biomembrane-wrapped gene delivery nanoparticles for cancer therapyJie Li0Jie Li1Huamin Zeng2Luwei Li3Ming Song4Mingqing Dong5Mingqing Dong6Department of Geriatrics, Chengdu Fifth People’s Hospital, Geriatric Diseases Institute of Chengdu, Chengdu, Sichuan, ChinaCenter for Medicine Research and Translation, Chengdu Fifth People’s Hospital, Chengdu, Sichuan, ChinaChengdu Ping An Healthcare Medical Examination Laboratory, Chengdu, Sichuan, ChinaCollege of Clinical Medical, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, ChinaDepartment of Pathophysiology, Shenzhen University Health Science Center, Shenzhen, Guangdong, ChinaDepartment of Geriatrics, Chengdu Fifth People’s Hospital, Geriatric Diseases Institute of Chengdu, Chengdu, Sichuan, ChinaCenter for Medicine Research and Translation, Chengdu Fifth People’s Hospital, Chengdu, Sichuan, ChinaAs a promising strategy, gene delivery for cancer treatment accepts encouraging progress due to its high efficacy, low toxicity, and exclusive selectivity. However, the delivery efficiency, specific biological distribution, targeted uptake, and biosafety of naked nucleic acid agents still face serious challenges, which limit further clinical application. To overcome the above bottleneck, safe and efficient functional nanovectors are developed to improve the delivery efficiency of nucleic acid agents. In recent years, emerging membrane-wrapped biomimetic nanoparticles (MBNPs) based on the concept of “imitating nature” are well known for their advantages, such as low immunogenicity and long cycle time, and especially play a crucial role in improving the overall efficiency of gene delivery and reducing adverse reactions. Therefore, combining MBNPs and gene delivery is an effective strategy to enhance tumor treatment efficiency. This review presents the mechanism of gene therapy and the current obstacles to gene delivery. Remarkably, the latest development of gene delivery MBNPs and the strategies to overcome these obstacles are summarized. Finally, the future challenges and prospects of gene delivery MBNPs toward clinical transformation are introduced. The principal purpose of this review is to discuss the biomedical potential of gene delivery MBNPs for cancer therapy and to provide guidance for further enhancing the efficiency of tumor gene therapy.https://www.frontiersin.org/articles/10.3389/fbioe.2023.1211753/fullgene deliverymembrane-wrapped biomimetic nanovectorsadvantages and obstaclestumor targetingefficacy improvement strategies |
| spellingShingle | Jie Li Jie Li Huamin Zeng Luwei Li Ming Song Mingqing Dong Mingqing Dong Biomembrane-wrapped gene delivery nanoparticles for cancer therapy Frontiers in Bioengineering and Biotechnology gene delivery membrane-wrapped biomimetic nanovectors advantages and obstacles tumor targeting efficacy improvement strategies |
| title | Biomembrane-wrapped gene delivery nanoparticles for cancer therapy |
| title_full | Biomembrane-wrapped gene delivery nanoparticles for cancer therapy |
| title_fullStr | Biomembrane-wrapped gene delivery nanoparticles for cancer therapy |
| title_full_unstemmed | Biomembrane-wrapped gene delivery nanoparticles for cancer therapy |
| title_short | Biomembrane-wrapped gene delivery nanoparticles for cancer therapy |
| title_sort | biomembrane wrapped gene delivery nanoparticles for cancer therapy |
| topic | gene delivery membrane-wrapped biomimetic nanovectors advantages and obstacles tumor targeting efficacy improvement strategies |
| url | https://www.frontiersin.org/articles/10.3389/fbioe.2023.1211753/full |
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