Ubiquitin-specific protease 22 is critical to in vivo angiogenesis, growth and metastasis of non-small cell lung cancer

Ubiquitin-specific protease 22 is critical to in vivo angiogenesis, growth and metastasis of non-small cell lung cancer

Abstract Background Loss of monoubiquitination of histone H2B (H2Bub1) was found to be associated with poor differentiation, cancer stemness, and enhanced malignancy of non-small cell lung cancer (NSCLC). Herein, we investigated the biological significance and therapeutic implications of ubiquitin-s...

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Bibliographic Details
Main Authors: Keqiang Zhang, Lu Yang, Jinhui Wang, Ting Sun, Yuming Guo, Rebecca Nelson, Tommy R. Tong, Rajendra Pangeni, Ravi Salgia, Dan J. Raz
Format: Article
Language:English
Published: BMC 2019-12-01
Series:Cell Communication and Signaling
Subjects:
Non-small cell lung cancer (NSCLC)
USP22
Angiogenesis
Epithelial-mesenchymal transition (EMT)
Growth
Metastasis
Online Access:https://doi.org/10.1186/s12964-019-0480-x

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