Are all antibiotic persisters created equal?
Antibiotic persisters are a sub-population of bacteria able to survive in the presence of bactericidal antibiotic despite the lack of heritable drug resistance mechanisms. This phenomenon exists across many bacterial species and is observed for many different antibiotics. Though these bacteria are o...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-08-01
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| Series: | Frontiers in Cellular and Infection Microbiology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fcimb.2022.933458/full |
| _version_ | 1811215089146003456 |
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| author | Michael W. Shultis Claire V. Mulholland Michael Berney |
| author_facet | Michael W. Shultis Claire V. Mulholland Michael Berney |
| author_sort | Michael W. Shultis |
| collection | DOAJ |
| description | Antibiotic persisters are a sub-population of bacteria able to survive in the presence of bactericidal antibiotic despite the lack of heritable drug resistance mechanisms. This phenomenon exists across many bacterial species and is observed for many different antibiotics. Though these bacteria are often described as “multidrug persisters” very few experiments have been carried out to determine the homogeneity of a persister population to different drugs. Further, there is much debate in the field as to the origins of a persister cell. Is it formed spontaneously? Does it form in response to stress? These questions are particularly pressing in the field of Mycobacterium tuberculosis, where persisters may play a crucial role in the required length of treatment and the development of multidrug resistant organisms. Here we aim to interpret the known mechanisms of antibiotic persistence and how they may relate to improving treatments for M. tuberculosis, exposing the gaps in knowledge that prevent us from answering the question: Are all antibiotic persisters created equal? |
| first_indexed | 2024-04-12T06:15:31Z |
| format | Article |
| id | doaj.art-f3bec105bd2e453c8eaaae02e64b2d86 |
| institution | Directory Open Access Journal |
| issn | 2235-2988 |
| language | English |
| last_indexed | 2024-04-12T06:15:31Z |
| publishDate | 2022-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cellular and Infection Microbiology |
| spelling | doaj.art-f3bec105bd2e453c8eaaae02e64b2d862022-12-22T03:44:30ZengFrontiers Media S.A.Frontiers in Cellular and Infection Microbiology2235-29882022-08-011210.3389/fcimb.2022.933458933458Are all antibiotic persisters created equal?Michael W. ShultisClaire V. MulhollandMichael BerneyAntibiotic persisters are a sub-population of bacteria able to survive in the presence of bactericidal antibiotic despite the lack of heritable drug resistance mechanisms. This phenomenon exists across many bacterial species and is observed for many different antibiotics. Though these bacteria are often described as “multidrug persisters” very few experiments have been carried out to determine the homogeneity of a persister population to different drugs. Further, there is much debate in the field as to the origins of a persister cell. Is it formed spontaneously? Does it form in response to stress? These questions are particularly pressing in the field of Mycobacterium tuberculosis, where persisters may play a crucial role in the required length of treatment and the development of multidrug resistant organisms. Here we aim to interpret the known mechanisms of antibiotic persistence and how they may relate to improving treatments for M. tuberculosis, exposing the gaps in knowledge that prevent us from answering the question: Are all antibiotic persisters created equal?https://www.frontiersin.org/articles/10.3389/fcimb.2022.933458/fullmycobacteriatuberculosismultidrugpersisterpersistencetolerance |
| spellingShingle | Michael W. Shultis Claire V. Mulholland Michael Berney Are all antibiotic persisters created equal? Frontiers in Cellular and Infection Microbiology mycobacteria tuberculosis multidrug persister persistence tolerance |
| title | Are all antibiotic persisters created equal? |
| title_full | Are all antibiotic persisters created equal? |
| title_fullStr | Are all antibiotic persisters created equal? |
| title_full_unstemmed | Are all antibiotic persisters created equal? |
| title_short | Are all antibiotic persisters created equal? |
| title_sort | are all antibiotic persisters created equal |
| topic | mycobacteria tuberculosis multidrug persister persistence tolerance |
| url | https://www.frontiersin.org/articles/10.3389/fcimb.2022.933458/full |
| work_keys_str_mv | AT michaelwshultis areallantibioticpersisterscreatedequal AT clairevmulholland areallantibioticpersisterscreatedequal AT michaelberney areallantibioticpersisterscreatedequal |