Gastro-intestinal lesions are not relatable to diarrhoea or specific pathogens in post-weaning diarrhoea (PWD) in pigs
Abstract Background Post-weaning diarrhoea (PWD) is a multifactorial condition and the most well documented infectious cause is enterotoxigenic Escherichia coli. The objective of the study was to investigate possible associations between pathological manifestations and pathogens in pigs with and wit...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-07-01
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| Series: | Acta Veterinaria Scandinavica |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13028-023-00693-y |
| _version_ | 1827905402889568256 |
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| author | Sophie Amalie Blirup-Plum Henrik Elvang Jensen Søren Saxmose Nielsen Karen Pankoke Mette Sif Hansen Ken Steen Pedersen Esben Østergaard Eriksen Jens Peter Nielsen John Elmerdahl Olsen Egle Kudirkiene Lars Erik Larsen Nicole Bakkegård Goecke Kristiane Barington |
| author_facet | Sophie Amalie Blirup-Plum Henrik Elvang Jensen Søren Saxmose Nielsen Karen Pankoke Mette Sif Hansen Ken Steen Pedersen Esben Østergaard Eriksen Jens Peter Nielsen John Elmerdahl Olsen Egle Kudirkiene Lars Erik Larsen Nicole Bakkegård Goecke Kristiane Barington |
| author_sort | Sophie Amalie Blirup-Plum |
| collection | DOAJ |
| description | Abstract Background Post-weaning diarrhoea (PWD) is a multifactorial condition and the most well documented infectious cause is enterotoxigenic Escherichia coli. The objective of the study was to investigate possible associations between pathological manifestations and pathogens in pigs with and without PWD. The study was conducted as a case–control study and included a total of 173 pigs from 9 different commercial intensive indoor production herds in eastern Denmark. Results Based on clinical examination, a total of 89 piglets with PWD (cases) and 84 piglets without PWD (controls) were included. Most of the pigs (n = 105/173) presented gastric lesions, which were more frequently observed in the control group. The odds of gastric ulcers were lower among pigs with PWD compared to pigs without PWD with an odds ratio (OR) of 0.2 (0.0; 0.7). Abnormal content in the colon was associated with PWD, with an OR of 6.5 (3.2; 14.3). No apparent association was found between lesions and the various pathogens or a combination of these. The odds of neutrophilic granulocyte infiltration were lower in the jejunum among pigs with PWD (OR 0.3 [0.1; 0.6]) compared to pigs without PWD. The association between neutrophilic granulocyte infiltration in jejunum and PWD differed between the herds (P = 0.03). Furthermore, the associations between PWD and hyperleukocytosis (P = 0.04) or infiltration of eosinophilic granulocytes (P = 0.04) in ileum were also herd dependent. Histopathology revealed several lesions not relatable to PWD. Conclusion The association between lesions and specific pathogens or PWD is more complex than anticipated. |
| first_indexed | 2024-03-13T00:41:11Z |
| format | Article |
| id | doaj.art-f3c00fdd90604718957fa9b570ab9cc5 |
| institution | Directory Open Access Journal |
| issn | 1751-0147 |
| language | English |
| last_indexed | 2024-03-13T00:41:11Z |
| publishDate | 2023-07-01 |
| publisher | BMC |
| record_format | Article |
| series | Acta Veterinaria Scandinavica |
| spelling | doaj.art-f3c00fdd90604718957fa9b570ab9cc52023-07-09T11:20:11ZengBMCActa Veterinaria Scandinavica1751-01472023-07-0165111810.1186/s13028-023-00693-yGastro-intestinal lesions are not relatable to diarrhoea or specific pathogens in post-weaning diarrhoea (PWD) in pigsSophie Amalie Blirup-Plum0Henrik Elvang Jensen1Søren Saxmose Nielsen2Karen Pankoke3Mette Sif Hansen4Ken Steen Pedersen5Esben Østergaard Eriksen6Jens Peter Nielsen7John Elmerdahl Olsen8Egle Kudirkiene9Lars Erik Larsen10Nicole Bakkegård Goecke11Kristiane Barington12Department of Veterinary and Animal Sciences, University of CopenhagenDepartment of Veterinary and Animal Sciences, University of CopenhagenDepartment of Veterinary and Animal Sciences, University of CopenhagenDepartment of Veterinary and Animal Sciences, University of CopenhagenDepartment of Veterinary and Animal Sciences, University of CopenhagenDepartment of Veterinary and Animal Sciences, University of CopenhagenDepartment of Veterinary and Animal Sciences, University of CopenhagenDepartment of Veterinary and Animal Sciences, University of CopenhagenDepartment of Veterinary and Animal Sciences, University of CopenhagenDepartment of Veterinary and Animal Sciences, University of CopenhagenDepartment of Veterinary and Animal Sciences, University of CopenhagenDepartment of Veterinary and Animal Sciences, University of CopenhagenDepartment of Veterinary and Animal Sciences, University of CopenhagenAbstract Background Post-weaning diarrhoea (PWD) is a multifactorial condition and the most well documented infectious cause is enterotoxigenic Escherichia coli. The objective of the study was to investigate possible associations between pathological manifestations and pathogens in pigs with and without PWD. The study was conducted as a case–control study and included a total of 173 pigs from 9 different commercial intensive indoor production herds in eastern Denmark. Results Based on clinical examination, a total of 89 piglets with PWD (cases) and 84 piglets without PWD (controls) were included. Most of the pigs (n = 105/173) presented gastric lesions, which were more frequently observed in the control group. The odds of gastric ulcers were lower among pigs with PWD compared to pigs without PWD with an odds ratio (OR) of 0.2 (0.0; 0.7). Abnormal content in the colon was associated with PWD, with an OR of 6.5 (3.2; 14.3). No apparent association was found between lesions and the various pathogens or a combination of these. The odds of neutrophilic granulocyte infiltration were lower in the jejunum among pigs with PWD (OR 0.3 [0.1; 0.6]) compared to pigs without PWD. The association between neutrophilic granulocyte infiltration in jejunum and PWD differed between the herds (P = 0.03). Furthermore, the associations between PWD and hyperleukocytosis (P = 0.04) or infiltration of eosinophilic granulocytes (P = 0.04) in ileum were also herd dependent. Histopathology revealed several lesions not relatable to PWD. Conclusion The association between lesions and specific pathogens or PWD is more complex than anticipated.https://doi.org/10.1186/s13028-023-00693-yHistopathologyMicrobiologyPigsPost-weaning diarrhoea |
| spellingShingle | Sophie Amalie Blirup-Plum Henrik Elvang Jensen Søren Saxmose Nielsen Karen Pankoke Mette Sif Hansen Ken Steen Pedersen Esben Østergaard Eriksen Jens Peter Nielsen John Elmerdahl Olsen Egle Kudirkiene Lars Erik Larsen Nicole Bakkegård Goecke Kristiane Barington Gastro-intestinal lesions are not relatable to diarrhoea or specific pathogens in post-weaning diarrhoea (PWD) in pigs Acta Veterinaria Scandinavica Histopathology Microbiology Pigs Post-weaning diarrhoea |
| title | Gastro-intestinal lesions are not relatable to diarrhoea or specific pathogens in post-weaning diarrhoea (PWD) in pigs |
| title_full | Gastro-intestinal lesions are not relatable to diarrhoea or specific pathogens in post-weaning diarrhoea (PWD) in pigs |
| title_fullStr | Gastro-intestinal lesions are not relatable to diarrhoea or specific pathogens in post-weaning diarrhoea (PWD) in pigs |
| title_full_unstemmed | Gastro-intestinal lesions are not relatable to diarrhoea or specific pathogens in post-weaning diarrhoea (PWD) in pigs |
| title_short | Gastro-intestinal lesions are not relatable to diarrhoea or specific pathogens in post-weaning diarrhoea (PWD) in pigs |
| title_sort | gastro intestinal lesions are not relatable to diarrhoea or specific pathogens in post weaning diarrhoea pwd in pigs |
| topic | Histopathology Microbiology Pigs Post-weaning diarrhoea |
| url | https://doi.org/10.1186/s13028-023-00693-y |
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