Age associations with neural processing of reward anticipation in adolescents with bipolar disorders
Reward/behavioral approach system hypersensitivity is implicated in bipolar disorders (BD) and in normative development during adolescence. Pediatric onset of BD is associated with a more severe illness course. However, little is known about neural processing of rewards in adolescents with BD or dev...
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| Format: | Article |
| Language: | English |
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Elsevier
2016-01-01
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| Series: | NeuroImage: Clinical |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213158216300547 |
| _version_ | 1819259884185583616 |
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| author | Snežana Urošević Monica Luciana Jonathan B. Jensen Eric A. Youngstrom Kathleen M. Thomas |
| author_facet | Snežana Urošević Monica Luciana Jonathan B. Jensen Eric A. Youngstrom Kathleen M. Thomas |
| author_sort | Snežana Urošević |
| collection | DOAJ |
| description | Reward/behavioral approach system hypersensitivity is implicated in bipolar disorders (BD) and in normative development during adolescence. Pediatric onset of BD is associated with a more severe illness course. However, little is known about neural processing of rewards in adolescents with BD or developmental (i.e., age) associations with activation of these neural systems. The present study aims to address this knowledge gap. The present sample included 21 adolescents with BD and 26 healthy adolescents, ages 13 to 19. Participants completed a functional magnetic resonance imaging (fMRI) protocol using the Monetary Incentive Delay (MID) task. Behavioral performance was similar between groups. Group differences in BOLD activation during target anticipation and feedback anticipation periods of the task were examined using whole-brain analyses, as were group differences in age effects. During both target anticipation and feedback anticipation, adolescents with BD, compared to adolescents without psychopathology, exhibited decreased engagement of frontal regions involved in cognitive control (i.e., dorsolateral prefrontal cortex). Healthy adolescents exhibited age-related decreases, while adolescents with BD exhibited age-related increases, in activity of other cognitive control frontal areas (i.e., right inferior frontal gyrus), suggesting altered development in the BD group. Longitudinal research is needed to examine potentially abnormal development of cognitive control during reward pursuit in adolescent BD and whether early therapeutic interventions can prevent these potential deviations from normative development. |
| first_indexed | 2024-12-23T19:17:06Z |
| format | Article |
| id | doaj.art-f3c020c1b00940a98905cd9031ba9525 |
| institution | Directory Open Access Journal |
| issn | 2213-1582 |
| language | English |
| last_indexed | 2024-12-23T19:17:06Z |
| publishDate | 2016-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | NeuroImage: Clinical |
| spelling | doaj.art-f3c020c1b00940a98905cd9031ba95252022-12-21T17:34:17ZengElsevierNeuroImage: Clinical2213-15822016-01-0111C47648510.1016/j.nicl.2016.03.013Age associations with neural processing of reward anticipation in adolescents with bipolar disordersSnežana Urošević0Monica Luciana1Jonathan B. Jensen2Eric A. Youngstrom3Kathleen M. Thomas4Department of Psychology, University of Minnesota—Twin Cities, United StatesDepartment of Psychology, University of Minnesota—Twin Cities, United StatesDepartment of Psychiatry, University of Minnesota—Twin Cities, United StatesDepartment of Psychology, University of North Carolina—Chapel Hill, United StatesCenter for Neurobehavioral Development, University of Minnesota—Twin Cities, United StatesReward/behavioral approach system hypersensitivity is implicated in bipolar disorders (BD) and in normative development during adolescence. Pediatric onset of BD is associated with a more severe illness course. However, little is known about neural processing of rewards in adolescents with BD or developmental (i.e., age) associations with activation of these neural systems. The present study aims to address this knowledge gap. The present sample included 21 adolescents with BD and 26 healthy adolescents, ages 13 to 19. Participants completed a functional magnetic resonance imaging (fMRI) protocol using the Monetary Incentive Delay (MID) task. Behavioral performance was similar between groups. Group differences in BOLD activation during target anticipation and feedback anticipation periods of the task were examined using whole-brain analyses, as were group differences in age effects. During both target anticipation and feedback anticipation, adolescents with BD, compared to adolescents without psychopathology, exhibited decreased engagement of frontal regions involved in cognitive control (i.e., dorsolateral prefrontal cortex). Healthy adolescents exhibited age-related decreases, while adolescents with BD exhibited age-related increases, in activity of other cognitive control frontal areas (i.e., right inferior frontal gyrus), suggesting altered development in the BD group. Longitudinal research is needed to examine potentially abnormal development of cognitive control during reward pursuit in adolescent BD and whether early therapeutic interventions can prevent these potential deviations from normative development.http://www.sciencedirect.com/science/article/pii/S2213158216300547Bipolar disorderAdolescenceRewardBAS dysregulationfMRI |
| spellingShingle | Snežana Urošević Monica Luciana Jonathan B. Jensen Eric A. Youngstrom Kathleen M. Thomas Age associations with neural processing of reward anticipation in adolescents with bipolar disorders NeuroImage: Clinical Bipolar disorder Adolescence Reward BAS dysregulation fMRI |
| title | Age associations with neural processing of reward anticipation in adolescents with bipolar disorders |
| title_full | Age associations with neural processing of reward anticipation in adolescents with bipolar disorders |
| title_fullStr | Age associations with neural processing of reward anticipation in adolescents with bipolar disorders |
| title_full_unstemmed | Age associations with neural processing of reward anticipation in adolescents with bipolar disorders |
| title_short | Age associations with neural processing of reward anticipation in adolescents with bipolar disorders |
| title_sort | age associations with neural processing of reward anticipation in adolescents with bipolar disorders |
| topic | Bipolar disorder Adolescence Reward BAS dysregulation fMRI |
| url | http://www.sciencedirect.com/science/article/pii/S2213158216300547 |
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