Predicting hospital-acquired pneumonia among schizophrenic patients: a machine learning approach
Abstract Background Medications are frequently used for treating schizophrenia, however, anti-psychotic drug use is known to lead to cases of pneumonia. The purpose of our study is to build a model for predicting hospital-acquired pneumonia among schizophrenic patients by adopting machine learning t...
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| Format: | Article |
| Language: | English |
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BMC
2019-03-01
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| Series: | BMC Medical Informatics and Decision Making |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12911-019-0792-1 |
| _version_ | 1818856073499508736 |
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| author | Kuang Ming Kuo Paul C. Talley Chi Hsien Huang Liang Chih Cheng |
| author_facet | Kuang Ming Kuo Paul C. Talley Chi Hsien Huang Liang Chih Cheng |
| author_sort | Kuang Ming Kuo |
| collection | DOAJ |
| description | Abstract Background Medications are frequently used for treating schizophrenia, however, anti-psychotic drug use is known to lead to cases of pneumonia. The purpose of our study is to build a model for predicting hospital-acquired pneumonia among schizophrenic patients by adopting machine learning techniques. Methods Data related to a total of 185 schizophrenic in-patients at a Taiwanese district mental hospital diagnosed with pneumonia between 2013 ~ 2018 were gathered. Eleven predictors, including gender, age, clozapine use, drug-drug interaction, dosage, duration of medication, coughing, change of leukocyte count, change of neutrophil count, change of blood sugar level, change of body weight, were used to predict the onset of pneumonia. Seven machine learning algorithms, including classification and regression tree, decision tree, k-nearest neighbors, naïve Bayes, random forest, support vector machine, and logistic regression were utilized to build predictive models used in this study. Accuracy, area under receiver operating characteristic curve, sensitivity, specificity, and kappa were used to measure overall model performance. Results Among the seven adopted machine learning algorithms, random forest and decision tree exhibited the optimal predictive accuracy versus the remaining algorithms. Further, six most important risk factors, including, dosage, clozapine use, duration of medication, change of neutrophil count, change of leukocyte count, and drug-drug interaction, were also identified. Conclusions Although schizophrenic patients remain susceptible to the threat of pneumonia whenever treated with anti-psychotic drugs, our predictive model may serve as a useful support tool for physicians treating such patients. |
| first_indexed | 2024-12-19T08:18:42Z |
| format | Article |
| id | doaj.art-f3c0c4c4728f4762aab8c5ae263f5b26 |
| institution | Directory Open Access Journal |
| issn | 1472-6947 |
| language | English |
| last_indexed | 2024-12-19T08:18:42Z |
| publishDate | 2019-03-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Medical Informatics and Decision Making |
| spelling | doaj.art-f3c0c4c4728f4762aab8c5ae263f5b262022-12-21T20:29:27ZengBMCBMC Medical Informatics and Decision Making1472-69472019-03-011911810.1186/s12911-019-0792-1Predicting hospital-acquired pneumonia among schizophrenic patients: a machine learning approachKuang Ming Kuo0Paul C. Talley1Chi Hsien Huang2Liang Chih Cheng3Department of Healthcare Administration, I-Shou UniversityDepartment of Applied English, I-Shou UniversityDepartment of Community Healthcare & Geriatrics, Nagoya University Graduate School of MedicineDepartment of Healthcare Administration, I-Shou UniversityAbstract Background Medications are frequently used for treating schizophrenia, however, anti-psychotic drug use is known to lead to cases of pneumonia. The purpose of our study is to build a model for predicting hospital-acquired pneumonia among schizophrenic patients by adopting machine learning techniques. Methods Data related to a total of 185 schizophrenic in-patients at a Taiwanese district mental hospital diagnosed with pneumonia between 2013 ~ 2018 were gathered. Eleven predictors, including gender, age, clozapine use, drug-drug interaction, dosage, duration of medication, coughing, change of leukocyte count, change of neutrophil count, change of blood sugar level, change of body weight, were used to predict the onset of pneumonia. Seven machine learning algorithms, including classification and regression tree, decision tree, k-nearest neighbors, naïve Bayes, random forest, support vector machine, and logistic regression were utilized to build predictive models used in this study. Accuracy, area under receiver operating characteristic curve, sensitivity, specificity, and kappa were used to measure overall model performance. Results Among the seven adopted machine learning algorithms, random forest and decision tree exhibited the optimal predictive accuracy versus the remaining algorithms. Further, six most important risk factors, including, dosage, clozapine use, duration of medication, change of neutrophil count, change of leukocyte count, and drug-drug interaction, were also identified. Conclusions Although schizophrenic patients remain susceptible to the threat of pneumonia whenever treated with anti-psychotic drugs, our predictive model may serve as a useful support tool for physicians treating such patients.http://link.springer.com/article/10.1186/s12911-019-0792-1ClozapineMachine learningPneumoniaRisk factorsSchizophrenia |
| spellingShingle | Kuang Ming Kuo Paul C. Talley Chi Hsien Huang Liang Chih Cheng Predicting hospital-acquired pneumonia among schizophrenic patients: a machine learning approach BMC Medical Informatics and Decision Making Clozapine Machine learning Pneumonia Risk factors Schizophrenia |
| title | Predicting hospital-acquired pneumonia among schizophrenic patients: a machine learning approach |
| title_full | Predicting hospital-acquired pneumonia among schizophrenic patients: a machine learning approach |
| title_fullStr | Predicting hospital-acquired pneumonia among schizophrenic patients: a machine learning approach |
| title_full_unstemmed | Predicting hospital-acquired pneumonia among schizophrenic patients: a machine learning approach |
| title_short | Predicting hospital-acquired pneumonia among schizophrenic patients: a machine learning approach |
| title_sort | predicting hospital acquired pneumonia among schizophrenic patients a machine learning approach |
| topic | Clozapine Machine learning Pneumonia Risk factors Schizophrenia |
| url | http://link.springer.com/article/10.1186/s12911-019-0792-1 |
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