Molecular Mechanisms of the Antitumor Effects of Mesalazine and Its Preventive Potential in Colorectal Cancer
Chemoprevention is one of the ways to fight colorectal cancer, which is a huge challenge in oncology. Numerous pieces of evidence indicate that chronic inflammation in the course of Crohn’s disease or ulcerative colitis (UC) is a significant cancer risk factor. Epidemiologic studies suggest that lon...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-06-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/28/13/5081 |
| _version_ | 1797591174575292416 |
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| author | Joanna Słoka Marcel Madej Barbara Strzalka-Mrozik |
| author_facet | Joanna Słoka Marcel Madej Barbara Strzalka-Mrozik |
| author_sort | Joanna Słoka |
| collection | DOAJ |
| description | Chemoprevention is one of the ways to fight colorectal cancer, which is a huge challenge in oncology. Numerous pieces of evidence indicate that chronic inflammation in the course of Crohn’s disease or ulcerative colitis (UC) is a significant cancer risk factor. Epidemiologic studies suggest that long-term use of non-steroidal anti-inflammatory drugs (NSAIDs), including mesalazine, has beneficial effects on colitis-associated colorectal cancer. Mesalazine is a first-line therapy for UC and is also widely used for maintaining remission in UC. Data showed that mesalazine has antiproliferative properties associated with cyclooxygenase (COX) inhibition but can also act through COX-independent pathways. This review summarizes knowledge about mesalazine’s molecular mechanisms of action and chemopreventive effect by which it could interfere with colorectal cancer cell proliferation and survival. |
| first_indexed | 2024-03-11T01:34:44Z |
| format | Article |
| id | doaj.art-f3c254c204df46d590ea6d6d62038ce5 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-11T01:34:44Z |
| publishDate | 2023-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-f3c254c204df46d590ea6d6d62038ce52023-11-18T17:07:57ZengMDPI AGMolecules1420-30492023-06-012813508110.3390/molecules28135081Molecular Mechanisms of the Antitumor Effects of Mesalazine and Its Preventive Potential in Colorectal CancerJoanna Słoka0Marcel Madej1Barbara Strzalka-Mrozik2Department of Molecular Biology, Faculty of Pharmaceutical Sciences in Sosnowiec, Medical University of Silesia, 40-055 Katowice, PolandDepartment of Molecular Biology, Faculty of Pharmaceutical Sciences in Sosnowiec, Medical University of Silesia, 40-055 Katowice, PolandDepartment of Molecular Biology, Faculty of Pharmaceutical Sciences in Sosnowiec, Medical University of Silesia, 40-055 Katowice, PolandChemoprevention is one of the ways to fight colorectal cancer, which is a huge challenge in oncology. Numerous pieces of evidence indicate that chronic inflammation in the course of Crohn’s disease or ulcerative colitis (UC) is a significant cancer risk factor. Epidemiologic studies suggest that long-term use of non-steroidal anti-inflammatory drugs (NSAIDs), including mesalazine, has beneficial effects on colitis-associated colorectal cancer. Mesalazine is a first-line therapy for UC and is also widely used for maintaining remission in UC. Data showed that mesalazine has antiproliferative properties associated with cyclooxygenase (COX) inhibition but can also act through COX-independent pathways. This review summarizes knowledge about mesalazine’s molecular mechanisms of action and chemopreventive effect by which it could interfere with colorectal cancer cell proliferation and survival.https://www.mdpi.com/1420-3049/28/13/5081mesalazinecolorectal cancerWnt/β-catenin pathwaychemopreventioncancer stem cellsnon-steroidal anti-inflammatory drugs |
| spellingShingle | Joanna Słoka Marcel Madej Barbara Strzalka-Mrozik Molecular Mechanisms of the Antitumor Effects of Mesalazine and Its Preventive Potential in Colorectal Cancer Molecules mesalazine colorectal cancer Wnt/β-catenin pathway chemoprevention cancer stem cells non-steroidal anti-inflammatory drugs |
| title | Molecular Mechanisms of the Antitumor Effects of Mesalazine and Its Preventive Potential in Colorectal Cancer |
| title_full | Molecular Mechanisms of the Antitumor Effects of Mesalazine and Its Preventive Potential in Colorectal Cancer |
| title_fullStr | Molecular Mechanisms of the Antitumor Effects of Mesalazine and Its Preventive Potential in Colorectal Cancer |
| title_full_unstemmed | Molecular Mechanisms of the Antitumor Effects of Mesalazine and Its Preventive Potential in Colorectal Cancer |
| title_short | Molecular Mechanisms of the Antitumor Effects of Mesalazine and Its Preventive Potential in Colorectal Cancer |
| title_sort | molecular mechanisms of the antitumor effects of mesalazine and its preventive potential in colorectal cancer |
| topic | mesalazine colorectal cancer Wnt/β-catenin pathway chemoprevention cancer stem cells non-steroidal anti-inflammatory drugs |
| url | https://www.mdpi.com/1420-3049/28/13/5081 |
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