Intratumor heterogeneity and cell secretome promote chemotherapy resistance and progression of colorectal cancer
Abstract The major underlying cause for the high mortality rate in colorectal cancer (CRC) relies on its drug resistance, to which intratumor heterogeneity (ITH) contributes substantially. CRC tumors have been reported to comprise heterogeneous populations of cancer cells that can be grouped into 4...
Main Authors: | Julia Källberg, Alexandra Harrison, Valerie March, Santa Bērziņa, Ivan Nemazanyy, Oliver Kepp, Guido Kroemer, Sophie Mouillet-Richard, Pierre Laurent-Puig, Valérie Taly, Wenjin Xiao |
---|---|
Format: | Article |
Language: | English |
Published: |
Nature Publishing Group
2023-05-01
|
Series: | Cell Death and Disease |
Online Access: | https://doi.org/10.1038/s41419-023-05806-z |
Similar Items
-
Technological Advances in Tumor-On-Chip Technology: From Bench to Bedside
by: Santa Bērziņa, et al.
Published: (2021-08-01) -
Immunogenic chemotherapy sensitizes RAS-mutated colorectal cancers to immune checkpoint inhibitors
by: Lucillia Bezu, et al.
Published: (2023-12-01) -
Immunogenic Cell Stress and Death Sensitize Tumors to Immunotherapy
by: Oliver Kepp, et al.
Published: (2023-12-01) -
Radiochemotherapy-induced elevations of plasma HMGB1 levels predict therapeutic responses in cancer patients
by: Guido Kroemer, et al.
Published: (2021-01-01) -
Downregulation of mitochondrial complex I induces ROS production in colorectal cancer subtypes that differently controls migration
by: Jean Bastin, et al.
Published: (2023-08-01)