The susceptibility of <i>Trypanosoma congolense</i> isolated in Zambézia Province, Mozambique, to isometamidium chloride, diminazene aceturate and homidium chloride

Resistance to trypanocidal drugs has been detected in various African countries and is a serious impediment to the control of livestock trypanosomosis. To determine whether drug resistant trypanosome strains are present in the Zambézia Province of Mozambique a study was initiated. To assess the e...

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Main Authors: S. Jamal, I. Sigauque, C. Macuamule, L. Neves, T. Marcotty, B.L. Penzhorn, P. Van den Bossche
Format: Article
Language:English
Published: AOSIS 2005-09-01
Series:Onderstepoort Journal of Veterinary Research
Online Access:https://ojvr.org/index.php/ojvr/article/view/190
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author S. Jamal
I. Sigauque
C. Macuamule
L. Neves
T. Marcotty
B.L. Penzhorn
P. Van den Bossche
author_facet S. Jamal
I. Sigauque
C. Macuamule
L. Neves
T. Marcotty
B.L. Penzhorn
P. Van den Bossche
author_sort S. Jamal
collection DOAJ
description Resistance to trypanocidal drugs has been detected in various African countries and is a serious impediment to the control of livestock trypanosomosis. To determine whether drug resistant trypanosome strains are present in the Zambézia Province of Mozambique a study was initiated. To assess the effect of the farming system and the drug-use regimen on the development of drug resistance, trypanosome isolates were collected from cattle from subsistence and commercial livestock production systems. The susceptibility of seven isolates against isometamidium chloride, diminazene aceturate and homidium chloride was tested in mice using a multiple-dose test. In four of the seven isolates high levels of drug resistance to diminazene aceturate and isometamidium chloride were detected. In most cases the observed levels of drug resistance correlated with the drug-use practices in the particular livestock production system.
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spelling doaj.art-f3c4186ea59b4aae8521db5ed414c8922022-12-22T02:05:31ZengAOSISOnderstepoort Journal of Veterinary Research0030-24652219-06352005-09-0172433333810.4102/ojvr.v72i4.190181The susceptibility of <i>Trypanosoma congolense</i> isolated in Zambézia Province, Mozambique, to isometamidium chloride, diminazene aceturate and homidium chlorideS. JamalI. SigauqueC. MacuamuleL. NevesT. MarcottyB.L. PenzhornP. Van den BosscheResistance to trypanocidal drugs has been detected in various African countries and is a serious impediment to the control of livestock trypanosomosis. To determine whether drug resistant trypanosome strains are present in the Zambézia Province of Mozambique a study was initiated. To assess the effect of the farming system and the drug-use regimen on the development of drug resistance, trypanosome isolates were collected from cattle from subsistence and commercial livestock production systems. The susceptibility of seven isolates against isometamidium chloride, diminazene aceturate and homidium chloride was tested in mice using a multiple-dose test. In four of the seven isolates high levels of drug resistance to diminazene aceturate and isometamidium chloride were detected. In most cases the observed levels of drug resistance correlated with the drug-use practices in the particular livestock production system.https://ojvr.org/index.php/ojvr/article/view/190
spellingShingle S. Jamal
I. Sigauque
C. Macuamule
L. Neves
T. Marcotty
B.L. Penzhorn
P. Van den Bossche
The susceptibility of <i>Trypanosoma congolense</i> isolated in Zambézia Province, Mozambique, to isometamidium chloride, diminazene aceturate and homidium chloride
Onderstepoort Journal of Veterinary Research
title The susceptibility of <i>Trypanosoma congolense</i> isolated in Zambézia Province, Mozambique, to isometamidium chloride, diminazene aceturate and homidium chloride
title_full The susceptibility of <i>Trypanosoma congolense</i> isolated in Zambézia Province, Mozambique, to isometamidium chloride, diminazene aceturate and homidium chloride
title_fullStr The susceptibility of <i>Trypanosoma congolense</i> isolated in Zambézia Province, Mozambique, to isometamidium chloride, diminazene aceturate and homidium chloride
title_full_unstemmed The susceptibility of <i>Trypanosoma congolense</i> isolated in Zambézia Province, Mozambique, to isometamidium chloride, diminazene aceturate and homidium chloride
title_short The susceptibility of <i>Trypanosoma congolense</i> isolated in Zambézia Province, Mozambique, to isometamidium chloride, diminazene aceturate and homidium chloride
title_sort susceptibility of i trypanosoma congolense i isolated in zambezia province mozambique to isometamidium chloride diminazene aceturate and homidium chloride
url https://ojvr.org/index.php/ojvr/article/view/190
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