The susceptibility of <i>Trypanosoma congolense</i> isolated in Zambézia Province, Mozambique, to isometamidium chloride, diminazene aceturate and homidium chloride
Resistance to trypanocidal drugs has been detected in various African countries and is a serious impediment to the control of livestock trypanosomosis. To determine whether drug resistant trypanosome strains are present in the Zambézia Province of Mozambique a study was initiated. To assess the e...
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Format: | Article |
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AOSIS
2005-09-01
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Series: | Onderstepoort Journal of Veterinary Research |
Online Access: | https://ojvr.org/index.php/ojvr/article/view/190 |
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author | S. Jamal I. Sigauque C. Macuamule L. Neves T. Marcotty B.L. Penzhorn P. Van den Bossche |
author_facet | S. Jamal I. Sigauque C. Macuamule L. Neves T. Marcotty B.L. Penzhorn P. Van den Bossche |
author_sort | S. Jamal |
collection | DOAJ |
description | Resistance to trypanocidal drugs has been detected in various African countries and is a serious impediment to the control of livestock trypanosomosis. To determine whether drug resistant trypanosome strains are present in the Zambézia Province of Mozambique a study was initiated. To assess the effect of the farming system and the drug-use regimen on the development of drug resistance, trypanosome isolates were collected from cattle from subsistence and commercial livestock production systems. The susceptibility of seven isolates against isometamidium chloride, diminazene aceturate and homidium chloride was tested in mice using a multiple-dose test. In four of the seven isolates high levels of drug resistance to diminazene aceturate and isometamidium chloride were detected. In most cases the observed levels of drug resistance correlated with the drug-use practices in the particular livestock production system. |
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issn | 0030-2465 2219-0635 |
language | English |
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spelling | doaj.art-f3c4186ea59b4aae8521db5ed414c8922022-12-22T02:05:31ZengAOSISOnderstepoort Journal of Veterinary Research0030-24652219-06352005-09-0172433333810.4102/ojvr.v72i4.190181The susceptibility of <i>Trypanosoma congolense</i> isolated in Zambézia Province, Mozambique, to isometamidium chloride, diminazene aceturate and homidium chlorideS. JamalI. SigauqueC. MacuamuleL. NevesT. MarcottyB.L. PenzhornP. Van den BosscheResistance to trypanocidal drugs has been detected in various African countries and is a serious impediment to the control of livestock trypanosomosis. To determine whether drug resistant trypanosome strains are present in the Zambézia Province of Mozambique a study was initiated. To assess the effect of the farming system and the drug-use regimen on the development of drug resistance, trypanosome isolates were collected from cattle from subsistence and commercial livestock production systems. The susceptibility of seven isolates against isometamidium chloride, diminazene aceturate and homidium chloride was tested in mice using a multiple-dose test. In four of the seven isolates high levels of drug resistance to diminazene aceturate and isometamidium chloride were detected. In most cases the observed levels of drug resistance correlated with the drug-use practices in the particular livestock production system.https://ojvr.org/index.php/ojvr/article/view/190 |
spellingShingle | S. Jamal I. Sigauque C. Macuamule L. Neves T. Marcotty B.L. Penzhorn P. Van den Bossche The susceptibility of <i>Trypanosoma congolense</i> isolated in Zambézia Province, Mozambique, to isometamidium chloride, diminazene aceturate and homidium chloride Onderstepoort Journal of Veterinary Research |
title | The susceptibility of <i>Trypanosoma congolense</i> isolated in Zambézia Province, Mozambique, to isometamidium chloride, diminazene aceturate and homidium chloride |
title_full | The susceptibility of <i>Trypanosoma congolense</i> isolated in Zambézia Province, Mozambique, to isometamidium chloride, diminazene aceturate and homidium chloride |
title_fullStr | The susceptibility of <i>Trypanosoma congolense</i> isolated in Zambézia Province, Mozambique, to isometamidium chloride, diminazene aceturate and homidium chloride |
title_full_unstemmed | The susceptibility of <i>Trypanosoma congolense</i> isolated in Zambézia Province, Mozambique, to isometamidium chloride, diminazene aceturate and homidium chloride |
title_short | The susceptibility of <i>Trypanosoma congolense</i> isolated in Zambézia Province, Mozambique, to isometamidium chloride, diminazene aceturate and homidium chloride |
title_sort | susceptibility of i trypanosoma congolense i isolated in zambezia province mozambique to isometamidium chloride diminazene aceturate and homidium chloride |
url | https://ojvr.org/index.php/ojvr/article/view/190 |
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