Decreasing auditory input induces neurogenesis impairment in the hippocampus
Abstract Hearing loss is associated with cognitive decline and dementia risk. Sensorineural hearing loss suppresses hippocampal neurogenesis, resulting in cognitive decline. However, the underlying mechanism of impaired neurogenesis and the role of microglial activation and stress responses related...
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2021-01-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-020-80218-z |
| _version_ | 1818997815562469376 |
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| author | Takaomi Kurioka Sachiyo Mogi Taku Yamashita |
| author_facet | Takaomi Kurioka Sachiyo Mogi Taku Yamashita |
| author_sort | Takaomi Kurioka |
| collection | DOAJ |
| description | Abstract Hearing loss is associated with cognitive decline and dementia risk. Sensorineural hearing loss suppresses hippocampal neurogenesis, resulting in cognitive decline. However, the underlying mechanism of impaired neurogenesis and the role of microglial activation and stress responses related to hearing loss in the hippocampus remains unknown. Using a conductive hearing loss (CHL) model, we investigated whether a decrease in sound level could induce impairment of hippocampal neurogenesis and examined the differences between unilateral CHL (uCHL) and bilateral CHL (bCHL). To establish the CHL mouse model, ears were unilaterally or bilaterally occluded for five weeks by auditory canal ligation. Although hearing thresholds were significantly increased following CHL, CHL mice exhibited no significant loss of spiral ganglion or hippocampal neurons. Hippocampal neurogenesis was significantly and equally decreased in both sides following uCHL. More severe decreases in hippocampal neurogenesis were observed in both sides in bCHL mice compared with that in uCHL mice. Furthermore, microglial invasion significantly increased following CHL. Serum cortisol levels, which indicate stress response, significantly increased following bCHL. Therefore, auditory deprivation could lead to increased microglial invasion and stress responses and might be a risk factor for hippocampal neurogenesis impairment. |
| first_indexed | 2024-12-20T21:51:38Z |
| format | Article |
| id | doaj.art-f3c8644fc6f9421aac6f095eb6ef58bf |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-12-20T21:51:38Z |
| publishDate | 2021-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-f3c8644fc6f9421aac6f095eb6ef58bf2022-12-21T19:25:33ZengNature PortfolioScientific Reports2045-23222021-01-0111111110.1038/s41598-020-80218-zDecreasing auditory input induces neurogenesis impairment in the hippocampusTakaomi Kurioka0Sachiyo Mogi1Taku Yamashita2Department of Otorhinolaryngology, Head and Neck Surgery, Kitasato UniversityDepartment of Otorhinolaryngology, Head and Neck Surgery, Kitasato UniversityDepartment of Otorhinolaryngology, Head and Neck Surgery, Kitasato UniversityAbstract Hearing loss is associated with cognitive decline and dementia risk. Sensorineural hearing loss suppresses hippocampal neurogenesis, resulting in cognitive decline. However, the underlying mechanism of impaired neurogenesis and the role of microglial activation and stress responses related to hearing loss in the hippocampus remains unknown. Using a conductive hearing loss (CHL) model, we investigated whether a decrease in sound level could induce impairment of hippocampal neurogenesis and examined the differences between unilateral CHL (uCHL) and bilateral CHL (bCHL). To establish the CHL mouse model, ears were unilaterally or bilaterally occluded for five weeks by auditory canal ligation. Although hearing thresholds were significantly increased following CHL, CHL mice exhibited no significant loss of spiral ganglion or hippocampal neurons. Hippocampal neurogenesis was significantly and equally decreased in both sides following uCHL. More severe decreases in hippocampal neurogenesis were observed in both sides in bCHL mice compared with that in uCHL mice. Furthermore, microglial invasion significantly increased following CHL. Serum cortisol levels, which indicate stress response, significantly increased following bCHL. Therefore, auditory deprivation could lead to increased microglial invasion and stress responses and might be a risk factor for hippocampal neurogenesis impairment.https://doi.org/10.1038/s41598-020-80218-z |
| spellingShingle | Takaomi Kurioka Sachiyo Mogi Taku Yamashita Decreasing auditory input induces neurogenesis impairment in the hippocampus Scientific Reports |
| title | Decreasing auditory input induces neurogenesis impairment in the hippocampus |
| title_full | Decreasing auditory input induces neurogenesis impairment in the hippocampus |
| title_fullStr | Decreasing auditory input induces neurogenesis impairment in the hippocampus |
| title_full_unstemmed | Decreasing auditory input induces neurogenesis impairment in the hippocampus |
| title_short | Decreasing auditory input induces neurogenesis impairment in the hippocampus |
| title_sort | decreasing auditory input induces neurogenesis impairment in the hippocampus |
| url | https://doi.org/10.1038/s41598-020-80218-z |
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