Single-Cell Transcriptomics Links Loss of Human Pancreatic β-Cell Identity to ER Stress

Single-Cell Transcriptomics Links Loss of Human Pancreatic β-Cell Identity to ER Stress

The maintenance of pancreatic islet architecture is crucial for proper β-cell function. We previously reported that disruption of human islet integrity could result in altered β-cell identity. Here we combine β-cell lineage tracing and single-cell transcriptomics to investigate the mechanisms underl...

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Bibliographic Details
Main Authors: Nathalie Groen, Floris Leenders, Ahmed Mahfouz, Amadeo Munoz-Garcia, Mauro J. Muraro, Natascha de Graaf, Ton. J. Rabelink, Rob Hoeben, Alexander van Oudenaarden, Arnaud Zaldumbide, Marcel J. T. Reinders, Eelco J. P. de Koning, Françoise Carlotti
Format: Article
Language:English
Published: MDPI AG 2021-12-01
Series:Cells
Subjects:
human pancreatic islets
β-cells
ER stress
islet integrity
single-cell RNAseq
type 2 diabetes
Online Access:https://www.mdpi.com/2073-4409/10/12/3585

Internet

https://www.mdpi.com/2073-4409/10/12/3585

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