Noninfectious Causes of Fever in 128 Patients with Systemic Lupus Erythematosus
Background: This study aimed to explore the clinical characteristics of noninfectious fever in patients with systemic lupus erythematosus (SLE) and the underlying causes through multivariate analysis. Methods: Clinical data of 128 patients with SLE who were admitted to Affiliated Hospital of Nanj...
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| Format: | Article |
| Language: | English |
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Tehran University of Medical Sciences
2019-01-01
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| Series: | Iranian Journal of Public Health |
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| Online Access: | https://ijph.tums.ac.ir/index.php/ijph/article/view/15939 |
| _version_ | 1811189496211832832 |
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| author | Feng GUO Jianmei CHEN Yu XIE Xueping ZHOU |
| author_facet | Feng GUO Jianmei CHEN Yu XIE Xueping ZHOU |
| author_sort | Feng GUO |
| collection | DOAJ |
| description | Background: This study aimed to explore the clinical characteristics of noninfectious fever in patients with systemic lupus erythematosus (SLE) and the underlying causes through multivariate analysis.
Methods: Clinical data of 128 patients with SLE who were admitted to Affiliated Hospital of Nanjing University of TCM, Nanjing 210029, P.R. China from January 2015 to December 2017 were retrospectively analyzed.
Results: The following factors were closely associated with fever: patient age, treatment history, SLEDAI score, enlarged liver, spleen and lymph nodes, low hemoglobin, leukopenia, CRP, complement C3, albumin, anti-dsDNA antibody, glucocorticoids, and cyclophosphamide. Multivariate logistic regression analysis showed that factors, such as enlarged liver, spleen and lymph nodes, digestive system involvement, low hemoglobin, leukopenia, CRP, decreased albumin, anti-dsDNA antibody, glucocorticoids and cyclophosphamide, were closely associated with noninfectious fever in SLE.
Conclusion: Noninfectious fever is a common clinical manifestation of SLE. Factors, such as enlarged liver, spleen and lymph nodes, digestive system involvement, low hemoglobin, leukopenia, CRP, decreased albumin, anti-dsDNA antibody, glucocorticoids, and cyclophosphamide, were independent risk factors for noninfectious fever in SLE. |
| first_indexed | 2024-04-11T14:36:55Z |
| format | Article |
| id | doaj.art-f3c91199060d47a28377836d34611fde |
| institution | Directory Open Access Journal |
| issn | 2251-6085 2251-6093 |
| language | English |
| last_indexed | 2024-04-11T14:36:55Z |
| publishDate | 2019-01-01 |
| publisher | Tehran University of Medical Sciences |
| record_format | Article |
| series | Iranian Journal of Public Health |
| spelling | doaj.art-f3c91199060d47a28377836d34611fde2022-12-22T04:18:19ZengTehran University of Medical SciencesIranian Journal of Public Health2251-60852251-60932019-01-0148110.18502/ijph.v48i1.783Noninfectious Causes of Fever in 128 Patients with Systemic Lupus ErythematosusFeng GUO0Jianmei CHEN1Yu XIE2Xueping ZHOU3Department of Rheumatism, Affiliated Hospital of Nanjing University of Traditional Chinese Medicine, Nanjing 210029, ChinaDepartment of Rheumatism, Affiliated Hospital of Nanjing University of Traditional Chinese Medicine, Nanjing 210029, ChinaDepartment of Rheumatism, Affiliated Hospital of Nanjing University of Traditional Chinese Medicine, Nanjing 210029, ChinaNanjing University of Chinese Medicine, Nanjing 210023, P.R. ChinaBackground: This study aimed to explore the clinical characteristics of noninfectious fever in patients with systemic lupus erythematosus (SLE) and the underlying causes through multivariate analysis. Methods: Clinical data of 128 patients with SLE who were admitted to Affiliated Hospital of Nanjing University of TCM, Nanjing 210029, P.R. China from January 2015 to December 2017 were retrospectively analyzed. Results: The following factors were closely associated with fever: patient age, treatment history, SLEDAI score, enlarged liver, spleen and lymph nodes, low hemoglobin, leukopenia, CRP, complement C3, albumin, anti-dsDNA antibody, glucocorticoids, and cyclophosphamide. Multivariate logistic regression analysis showed that factors, such as enlarged liver, spleen and lymph nodes, digestive system involvement, low hemoglobin, leukopenia, CRP, decreased albumin, anti-dsDNA antibody, glucocorticoids and cyclophosphamide, were closely associated with noninfectious fever in SLE. Conclusion: Noninfectious fever is a common clinical manifestation of SLE. Factors, such as enlarged liver, spleen and lymph nodes, digestive system involvement, low hemoglobin, leukopenia, CRP, decreased albumin, anti-dsDNA antibody, glucocorticoids, and cyclophosphamide, were independent risk factors for noninfectious fever in SLE.https://ijph.tums.ac.ir/index.php/ijph/article/view/15939Lupus erythematosusSystemic; FeverRisk factorsRetrospective study |
| spellingShingle | Feng GUO Jianmei CHEN Yu XIE Xueping ZHOU Noninfectious Causes of Fever in 128 Patients with Systemic Lupus Erythematosus Iranian Journal of Public Health Lupus erythematosus Systemic; Fever Risk factors Retrospective study |
| title | Noninfectious Causes of Fever in 128 Patients with Systemic Lupus Erythematosus |
| title_full | Noninfectious Causes of Fever in 128 Patients with Systemic Lupus Erythematosus |
| title_fullStr | Noninfectious Causes of Fever in 128 Patients with Systemic Lupus Erythematosus |
| title_full_unstemmed | Noninfectious Causes of Fever in 128 Patients with Systemic Lupus Erythematosus |
| title_short | Noninfectious Causes of Fever in 128 Patients with Systemic Lupus Erythematosus |
| title_sort | noninfectious causes of fever in 128 patients with systemic lupus erythematosus |
| topic | Lupus erythematosus Systemic; Fever Risk factors Retrospective study |
| url | https://ijph.tums.ac.ir/index.php/ijph/article/view/15939 |
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