Revascularization in acute intracranial large vessels occlusion: direct or bridging thrombectomy?
Guidelines for the early management of acute ischemic stroke recommend intravenous thrombolysis followed by endovascular treatment as the first choice for the treatment of stroke with large vessel occlusion within 4.5 h of symptom onset. However, intravenous thrombolysis before endovascular treatmen...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | zho |
| Published: |
Editorial Office of Journal of Third Military Medical University
2021-07-01
|
| Series: | Di-san junyi daxue xuebao |
| Subjects: | |
| Online Access: | http://aammt.tmmu.edu.cn/Upload/rhtml/202104153.htm |
| _version_ | 1818432175281799168 |
|---|---|
| author | YANG Qingwu ZI Wenjie |
| author_facet | YANG Qingwu ZI Wenjie |
| author_sort | YANG Qingwu |
| collection | DOAJ |
| description | Guidelines for the early management of acute ischemic stroke recommend intravenous thrombolysis followed by endovascular treatment as the first choice for the treatment of stroke with large vessel occlusion within 4.5 h of symptom onset. However, intravenous thrombolysis before endovascular treatment is a double-edged sword, which can not only bring benefits, but also increase risks. Currently, whether it is reasonable to omit intravenous thrombolysis and directly perform endovascular treatment is one of the most controversial issue. Four randomized, controlled, multicenter trial of direct endovascular treatment versus standard bridging therapy for acute stroke patients with large vessel occlusion in the anterior circulation demonstrated that the functional independence rate of the direct endovascular treatment group is similar to that of the intravenous thrombolysis followed by endovascular treatment group, and no significant difference was observed in the incidence of symptomatic intracerebral hemorrhage and mortality between the 2 treatment groups. Direct endovascular treatment may be used as a new option for patients with acute large vessel occlusion within 4.5 h of stroke onset. |
| first_indexed | 2024-12-14T16:01:01Z |
| format | Article |
| id | doaj.art-f3c99512b38e4784b8826f337c61b221 |
| institution | Directory Open Access Journal |
| issn | 1000-5404 |
| language | zho |
| last_indexed | 2024-12-14T16:01:01Z |
| publishDate | 2021-07-01 |
| publisher | Editorial Office of Journal of Third Military Medical University |
| record_format | Article |
| series | Di-san junyi daxue xuebao |
| spelling | doaj.art-f3c99512b38e4784b8826f337c61b2212022-12-21T22:55:11ZzhoEditorial Office of Journal of Third Military Medical UniversityDi-san junyi daxue xuebao1000-54042021-07-0143141299130310.16016/j.1000-5404.202104153Revascularization in acute intracranial large vessels occlusion: direct or bridging thrombectomy?YANG Qingwu0ZI Wenjie1Department of Neurology, Second Affiliated Hospital, Army Medical University(Third Military Medical University), Chongqing, 400037, China Department of Neurology, Second Affiliated Hospital, Army Medical University(Third Military Medical University), Chongqing, 400037, China Guidelines for the early management of acute ischemic stroke recommend intravenous thrombolysis followed by endovascular treatment as the first choice for the treatment of stroke with large vessel occlusion within 4.5 h of symptom onset. However, intravenous thrombolysis before endovascular treatment is a double-edged sword, which can not only bring benefits, but also increase risks. Currently, whether it is reasonable to omit intravenous thrombolysis and directly perform endovascular treatment is one of the most controversial issue. Four randomized, controlled, multicenter trial of direct endovascular treatment versus standard bridging therapy for acute stroke patients with large vessel occlusion in the anterior circulation demonstrated that the functional independence rate of the direct endovascular treatment group is similar to that of the intravenous thrombolysis followed by endovascular treatment group, and no significant difference was observed in the incidence of symptomatic intracerebral hemorrhage and mortality between the 2 treatment groups. Direct endovascular treatment may be used as a new option for patients with acute large vessel occlusion within 4.5 h of stroke onset.http://aammt.tmmu.edu.cn/Upload/rhtml/202104153.htmacute ischemic strokelarge vessel occlusionalteplaseintravenous thrombolysisendovasculartreatment |
| spellingShingle | YANG Qingwu ZI Wenjie Revascularization in acute intracranial large vessels occlusion: direct or bridging thrombectomy? Di-san junyi daxue xuebao acute ischemic stroke large vessel occlusion alteplase intravenous thrombolysis endovascular treatment |
| title | Revascularization in acute intracranial large vessels occlusion: direct or bridging thrombectomy? |
| title_full | Revascularization in acute intracranial large vessels occlusion: direct or bridging thrombectomy? |
| title_fullStr | Revascularization in acute intracranial large vessels occlusion: direct or bridging thrombectomy? |
| title_full_unstemmed | Revascularization in acute intracranial large vessels occlusion: direct or bridging thrombectomy? |
| title_short | Revascularization in acute intracranial large vessels occlusion: direct or bridging thrombectomy? |
| title_sort | revascularization in acute intracranial large vessels occlusion direct or bridging thrombectomy |
| topic | acute ischemic stroke large vessel occlusion alteplase intravenous thrombolysis endovascular treatment |
| url | http://aammt.tmmu.edu.cn/Upload/rhtml/202104153.htm |
| work_keys_str_mv | AT yangqingwu revascularizationinacuteintracraniallargevesselsocclusiondirectorbridgingthrombectomy AT ziwenjie revascularizationinacuteintracraniallargevesselsocclusiondirectorbridgingthrombectomy |