New targets of morphine postconditioning protection of the myocardium in ischemia/reperfusion injury: Involvement of HSP90/Akt and C5a/NF-κB

New targets of morphine postconditioning protection of the myocardium in ischemia/reperfusion injury: Involvement of HSP90/Akt and C5a/NF-κB

Activation of the complement component 5a (C5a) and nuclear factor κB (NF-κB) signaling is an important feature of myocardial ischemia/reperfusion (I/R) injury and recent studies show that morphine postconditioning (MP) attenuates the myocardial injury. However, the mediating cardioprotective mechan...

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Bibliographic Details
Main Authors: Tu Rong-Hui, Wang Dong-Xiao, Zhong Guo-Qiang, Meng Jian-Jun, Wen Hong, Jie-Feng, Bi Qi, He Yan
Format: Article
Language:English
Published: De Gruyter 2021-10-01
Series:Open Medicine
Subjects:
morphine postconditioning
hsp90
akt
c5a
nf-κb
Online Access:https://doi.org/10.1515/med-2021-0340
Description
Summary:Activation of the complement component 5a (C5a) and nuclear factor κB (NF-κB) signaling is an important feature of myocardial ischemia/reperfusion (I/R) injury and recent studies show that morphine postconditioning (MP) attenuates the myocardial injury. However, the mediating cardioprotective mechanisms remain unclear. The present study explores the role and interaction of heat shock protein 90 (HSP90), Akt, C5a, and NF-κB in MP-induced cardioprotection.
ISSN:2391-5463

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