New targets of morphine postconditioning protection of the myocardium in ischemia/reperfusion injury: Involvement of HSP90/Akt and C5a/NF-κB

New targets of morphine postconditioning protection of the myocardium in ischemia/reperfusion injury: Involvement of HSP90/Akt and C5a/NF-κB

Activation of the complement component 5a (C5a) and nuclear factor κB (NF-κB) signaling is an important feature of myocardial ischemia/reperfusion (I/R) injury and recent studies show that morphine postconditioning (MP) attenuates the myocardial injury. However, the mediating cardioprotective mechan...

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Bibliographic Details
Main Authors: Tu Rong-Hui, Wang Dong-Xiao, Zhong Guo-Qiang, Meng Jian-Jun, Wen Hong, Jie-Feng, Bi Qi, He Yan
Format: Article
Language:English
Published: De Gruyter 2021-10-01
Series:Open Medicine
Subjects:
morphine postconditioning
hsp90
akt
c5a
nf-κb
Online Access:https://doi.org/10.1515/med-2021-0340

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