Deep Phenotyping of Urinary Leukocytes by Mass Cytometry Reveals a Leukocyte Signature for Early and Non-Invasive Prediction of Response to Treatment in Active Lupus Nephritis

Deep Phenotyping of Urinary Leukocytes by Mass Cytometry Reveals a Leukocyte Signature for Early and Non-Invasive Prediction of Response to Treatment in Active Lupus Nephritis

Non-invasive biomarkers are necessary for diagnosis and monitoring disease activity in lupus nephritis (LN) to circumvent risks and limitations of renal biopsies. To identify new non-invasive cellular biomarkers in the urine sediment of LN patients, which may reflect kidney inflammation and can be u...

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Bibliographic Details
Main Authors: Martina Bertolo, Sabine Baumgart, Pawel Durek, Anette Peddinghaus, Henrik Mei, Thomas Rose, Philipp Enghard, Andreas Grützkau
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-03-01
Series:Frontiers in Immunology
Subjects:
systemic lupus – erythematosus
lupus nephritis
lupus nephritis biomarker
mass cytometry
urinary leukocytes
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.00256/full

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