Recent Progress of Cu-Catalyzed Azide-Alkyne Cycloaddition Reactions (CuAAC) in Sustainable Solvents: Glycerol, Deep Eutectic Solvents, and Aqueous Media
This mini-review presents a general overview of the progress achieved during the last decade on the amalgamation of CuAAC processes (copper-catalyzed azide-alkyne cycloaddition) with the employment of sustainable solvents as reaction media. In most of the presented examples, the use of water, glycer...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-04-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/25/9/2015 |
| _version_ | 1797569676026314752 |
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| author | Noel Nebra Joaquín García-Álvarez |
| author_facet | Noel Nebra Joaquín García-Álvarez |
| author_sort | Noel Nebra |
| collection | DOAJ |
| description | This mini-review presents a general overview of the progress achieved during the last decade on the amalgamation of CuAAC processes (copper-catalyzed azide-alkyne cycloaddition) with the employment of sustainable solvents as reaction media. In most of the presented examples, the use of water, glycerol (<i>Gly</i>), or deep eutectic solvents (<i>DESs</i>) as non-conventional reaction media allowed not only to recycle the catalytic system (thus reducing the amount of the copper catalyst needed per mole of substrate), but also to achieve higher conversions and selectivities when compared with the reaction promoted in hazardous and volatile organic solvents (<i>VOCs</i>). Moreover, the use of the aforementioned green solvents also permits the improvement of the overall sustainability of the Cu-catalyzed 1,3-dipolar cycloaddition process, thus fulfilling several important principles of green chemistry. |
| first_indexed | 2024-03-10T20:14:01Z |
| format | Article |
| id | doaj.art-f3cb56175d6948d3a9dea395fe98139c |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-10T20:14:01Z |
| publishDate | 2020-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-f3cb56175d6948d3a9dea395fe98139c2023-11-19T22:44:23ZengMDPI AGMolecules1420-30492020-04-01259201510.3390/molecules25092015Recent Progress of Cu-Catalyzed Azide-Alkyne Cycloaddition Reactions (CuAAC) in Sustainable Solvents: Glycerol, Deep Eutectic Solvents, and Aqueous MediaNoel Nebra0Joaquín García-Álvarez1UPS, CNRS, LHFA UMR 5069, Université de Toulouse, 118 Route de Narbonne, 31062 Toulouse, FranceDepartamento de Química Orgánica e Inorgánica, Instituto Universitario de Química Organometálica “Enrique Moles” (IUQOEM), Facultad de Química, Universidad de Oviedo, E-33071 Oviedo, SpainThis mini-review presents a general overview of the progress achieved during the last decade on the amalgamation of CuAAC processes (copper-catalyzed azide-alkyne cycloaddition) with the employment of sustainable solvents as reaction media. In most of the presented examples, the use of water, glycerol (<i>Gly</i>), or deep eutectic solvents (<i>DESs</i>) as non-conventional reaction media allowed not only to recycle the catalytic system (thus reducing the amount of the copper catalyst needed per mole of substrate), but also to achieve higher conversions and selectivities when compared with the reaction promoted in hazardous and volatile organic solvents (<i>VOCs</i>). Moreover, the use of the aforementioned green solvents also permits the improvement of the overall sustainability of the Cu-catalyzed 1,3-dipolar cycloaddition process, thus fulfilling several important principles of green chemistry.https://www.mdpi.com/1420-3049/25/9/2015CuAACwaterglyceroldeep eutectic solventscycloadditionsgreen chemistry |
| spellingShingle | Noel Nebra Joaquín García-Álvarez Recent Progress of Cu-Catalyzed Azide-Alkyne Cycloaddition Reactions (CuAAC) in Sustainable Solvents: Glycerol, Deep Eutectic Solvents, and Aqueous Media Molecules CuAAC water glycerol deep eutectic solvents cycloadditions green chemistry |
| title | Recent Progress of Cu-Catalyzed Azide-Alkyne Cycloaddition Reactions (CuAAC) in Sustainable Solvents: Glycerol, Deep Eutectic Solvents, and Aqueous Media |
| title_full | Recent Progress of Cu-Catalyzed Azide-Alkyne Cycloaddition Reactions (CuAAC) in Sustainable Solvents: Glycerol, Deep Eutectic Solvents, and Aqueous Media |
| title_fullStr | Recent Progress of Cu-Catalyzed Azide-Alkyne Cycloaddition Reactions (CuAAC) in Sustainable Solvents: Glycerol, Deep Eutectic Solvents, and Aqueous Media |
| title_full_unstemmed | Recent Progress of Cu-Catalyzed Azide-Alkyne Cycloaddition Reactions (CuAAC) in Sustainable Solvents: Glycerol, Deep Eutectic Solvents, and Aqueous Media |
| title_short | Recent Progress of Cu-Catalyzed Azide-Alkyne Cycloaddition Reactions (CuAAC) in Sustainable Solvents: Glycerol, Deep Eutectic Solvents, and Aqueous Media |
| title_sort | recent progress of cu catalyzed azide alkyne cycloaddition reactions cuaac in sustainable solvents glycerol deep eutectic solvents and aqueous media |
| topic | CuAAC water glycerol deep eutectic solvents cycloadditions green chemistry |
| url | https://www.mdpi.com/1420-3049/25/9/2015 |
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