MMP-13 regulates growth of wound granulation tissue and modulates gene expression signatures involved in inflammation, proteolysis, and cell viability.

MMP-13 regulates growth of wound granulation tissue and modulates gene expression signatures involved in inflammation, proteolysis, and cell viability.

Proteinases play a pivotal role in wound healing by regulating cell-matrix interactions and availability of bioactive molecules. The role of matrix metalloproteinase-13 (MMP-13) in granulation tissue growth was studied in subcutaneously implanted viscose cellulose sponge in MMP-13 knockout (Mmp13(-/...

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Bibliographic Details
Main Authors: Mervi Toriseva, Matti Laato, Olli Carpén, Suvi T Ruohonen, Eriika Savontaus, Masaki Inada, Stephen M Krane, Veli-Matti Kähäri
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3413640?pdf=render

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http://europepmc.org/articles/PMC3413640?pdf=render

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