The Relationship between Elevated Homocysteine and Metabolic Syndrome in a Community-Dwelling Middle-Aged and Elderly Population in Taiwan
(1) Background: Metabolic syndrome has become a serious health problem in society. Homocysteine is a biomarker for cardiovascular disease. We investigated the relationship between homocysteine levels and metabolic syndrome. (2) Methods: A total of 398 middle-aged and elderly individuals were include...
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MDPI AG
2023-01-01
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| Series: | Biomedicines |
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| Online Access: | https://www.mdpi.com/2227-9059/11/2/378 |
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| author | Yu-Lin Shih Chin-Chuan Shih Tzu-Cheng Huang Jau-Yuan Chen |
| author_facet | Yu-Lin Shih Chin-Chuan Shih Tzu-Cheng Huang Jau-Yuan Chen |
| author_sort | Yu-Lin Shih |
| collection | DOAJ |
| description | (1) Background: Metabolic syndrome has become a serious health problem in society. Homocysteine is a biomarker for cardiovascular disease. We investigated the relationship between homocysteine levels and metabolic syndrome. (2) Methods: A total of 398 middle-aged and elderly individuals were included in our study. First, we divided the participants into two groups: the metabolic syndrome group and the nonmetabolic syndrome group. Second, according to tertiles of homocysteine levels from low to high, the participants were divided into first, second, and third groups. Pearson’s correlation was then calculated for homocysteine levels and metabolic factors. Scatterplots are presented. Finally, the risk of metabolic syndrome in the second and third groups compared with the first group was assessed by multivariate logistic regression. (3) Results: In our study, the metabolic syndrome group had higher homocysteine levels, and the participants in the third group were more likely to have metabolic syndrome. Multivariate logistic regression revealed that the third group, which had the highest homocysteine level, was associated with metabolic syndrome with an odds ratio of 2.32 compared with the first group after adjusting for risk factors. (4) Conclusions: We concluded that high plasma homocysteine levels were independently associated with MetS in our study population. |
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| format | Article |
| id | doaj.art-f3ccfb8c54cb426bbf1921bbc79e84ac |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-11T09:07:29Z |
| publishDate | 2023-01-01 |
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| series | Biomedicines |
| spelling | doaj.art-f3ccfb8c54cb426bbf1921bbc79e84ac2023-11-16T19:17:19ZengMDPI AGBiomedicines2227-90592023-01-0111237810.3390/biomedicines11020378The Relationship between Elevated Homocysteine and Metabolic Syndrome in a Community-Dwelling Middle-Aged and Elderly Population in TaiwanYu-Lin Shih0Chin-Chuan Shih1Tzu-Cheng Huang2Jau-Yuan Chen3Department of Family Medicine, Chang-Gung Memorial Hospital, Linkou Branch, Taoyuan 333, TaiwanUnited Safety Medical Group, General Administrative Department, New Taipei City 242, TaiwanDepartment of Family Medicine, Chang-Gung Memorial Hospital, Linkou Branch, Taoyuan 333, TaiwanDepartment of Family Medicine, Chang-Gung Memorial Hospital, Linkou Branch, Taoyuan 333, Taiwan(1) Background: Metabolic syndrome has become a serious health problem in society. Homocysteine is a biomarker for cardiovascular disease. We investigated the relationship between homocysteine levels and metabolic syndrome. (2) Methods: A total of 398 middle-aged and elderly individuals were included in our study. First, we divided the participants into two groups: the metabolic syndrome group and the nonmetabolic syndrome group. Second, according to tertiles of homocysteine levels from low to high, the participants were divided into first, second, and third groups. Pearson’s correlation was then calculated for homocysteine levels and metabolic factors. Scatterplots are presented. Finally, the risk of metabolic syndrome in the second and third groups compared with the first group was assessed by multivariate logistic regression. (3) Results: In our study, the metabolic syndrome group had higher homocysteine levels, and the participants in the third group were more likely to have metabolic syndrome. Multivariate logistic regression revealed that the third group, which had the highest homocysteine level, was associated with metabolic syndrome with an odds ratio of 2.32 compared with the first group after adjusting for risk factors. (4) Conclusions: We concluded that high plasma homocysteine levels were independently associated with MetS in our study population.https://www.mdpi.com/2227-9059/11/2/378homocysteine levelmetabolic syndromemiddle-aged and elderlyobesitywaist circumference |
| spellingShingle | Yu-Lin Shih Chin-Chuan Shih Tzu-Cheng Huang Jau-Yuan Chen The Relationship between Elevated Homocysteine and Metabolic Syndrome in a Community-Dwelling Middle-Aged and Elderly Population in Taiwan Biomedicines homocysteine level metabolic syndrome middle-aged and elderly obesity waist circumference |
| title | The Relationship between Elevated Homocysteine and Metabolic Syndrome in a Community-Dwelling Middle-Aged and Elderly Population in Taiwan |
| title_full | The Relationship between Elevated Homocysteine and Metabolic Syndrome in a Community-Dwelling Middle-Aged and Elderly Population in Taiwan |
| title_fullStr | The Relationship between Elevated Homocysteine and Metabolic Syndrome in a Community-Dwelling Middle-Aged and Elderly Population in Taiwan |
| title_full_unstemmed | The Relationship between Elevated Homocysteine and Metabolic Syndrome in a Community-Dwelling Middle-Aged and Elderly Population in Taiwan |
| title_short | The Relationship between Elevated Homocysteine and Metabolic Syndrome in a Community-Dwelling Middle-Aged and Elderly Population in Taiwan |
| title_sort | relationship between elevated homocysteine and metabolic syndrome in a community dwelling middle aged and elderly population in taiwan |
| topic | homocysteine level metabolic syndrome middle-aged and elderly obesity waist circumference |
| url | https://www.mdpi.com/2227-9059/11/2/378 |
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