A dual mechanism promotes switching of the Stormorken STIM1 R304W mutant into the activated state
Stormorken syndrome is associated with the R304W mutation in STIM1, which is a Calcium sensor in the endoplasmic reticulum. Here authors use FRET and electrophysiology to show that R304W induces STIM1 conformational extension by a dual mechanism resulting in constitutive activation of Ca2+ channels.
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2018-02-01
|
| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-018-03062-w |
| _version_ | 1818684383421267968 |
|---|---|
| author | Marc Fahrner Michael Stadlbauer Martin Muik Petr Rathner Peter Stathopulos Mitsu Ikura Norbert Müller Christoph Romanin |
| author_facet | Marc Fahrner Michael Stadlbauer Martin Muik Petr Rathner Peter Stathopulos Mitsu Ikura Norbert Müller Christoph Romanin |
| author_sort | Marc Fahrner |
| collection | DOAJ |
| description | Stormorken syndrome is associated with the R304W mutation in STIM1, which is a Calcium sensor in the endoplasmic reticulum. Here authors use FRET and electrophysiology to show that R304W induces STIM1 conformational extension by a dual mechanism resulting in constitutive activation of Ca2+ channels. |
| first_indexed | 2024-12-17T10:49:46Z |
| format | Article |
| id | doaj.art-f3d205c02ef7403b8fda99785e3df276 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-17T10:49:46Z |
| publishDate | 2018-02-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-f3d205c02ef7403b8fda99785e3df2762022-12-21T21:52:02ZengNature PortfolioNature Communications2041-17232018-02-019111210.1038/s41467-018-03062-wA dual mechanism promotes switching of the Stormorken STIM1 R304W mutant into the activated stateMarc Fahrner0Michael Stadlbauer1Martin Muik2Petr Rathner3Peter Stathopulos4Mitsu Ikura5Norbert Müller6Christoph Romanin7Institute of Biophysics, Johannes Kepler University LinzInstitute of Biophysics, Johannes Kepler University LinzInstitute of Biophysics, Johannes Kepler University LinzInstitute of Organic Chemistry, Johannes Kepler University LinzDepartment of Physiology and Pharmacology, University of Western OntarioPrincess Margaret Cancer Center, University Health NetworkInstitute of Organic Chemistry, Johannes Kepler University LinzInstitute of Biophysics, Johannes Kepler University LinzStormorken syndrome is associated with the R304W mutation in STIM1, which is a Calcium sensor in the endoplasmic reticulum. Here authors use FRET and electrophysiology to show that R304W induces STIM1 conformational extension by a dual mechanism resulting in constitutive activation of Ca2+ channels.https://doi.org/10.1038/s41467-018-03062-w |
| spellingShingle | Marc Fahrner Michael Stadlbauer Martin Muik Petr Rathner Peter Stathopulos Mitsu Ikura Norbert Müller Christoph Romanin A dual mechanism promotes switching of the Stormorken STIM1 R304W mutant into the activated state Nature Communications |
| title | A dual mechanism promotes switching of the Stormorken STIM1 R304W mutant into the activated state |
| title_full | A dual mechanism promotes switching of the Stormorken STIM1 R304W mutant into the activated state |
| title_fullStr | A dual mechanism promotes switching of the Stormorken STIM1 R304W mutant into the activated state |
| title_full_unstemmed | A dual mechanism promotes switching of the Stormorken STIM1 R304W mutant into the activated state |
| title_short | A dual mechanism promotes switching of the Stormorken STIM1 R304W mutant into the activated state |
| title_sort | dual mechanism promotes switching of the stormorken stim1 r304w mutant into the activated state |
| url | https://doi.org/10.1038/s41467-018-03062-w |
| work_keys_str_mv | AT marcfahrner adualmechanismpromotesswitchingofthestormorkenstim1r304wmutantintotheactivatedstate AT michaelstadlbauer adualmechanismpromotesswitchingofthestormorkenstim1r304wmutantintotheactivatedstate AT martinmuik adualmechanismpromotesswitchingofthestormorkenstim1r304wmutantintotheactivatedstate AT petrrathner adualmechanismpromotesswitchingofthestormorkenstim1r304wmutantintotheactivatedstate AT peterstathopulos adualmechanismpromotesswitchingofthestormorkenstim1r304wmutantintotheactivatedstate AT mitsuikura adualmechanismpromotesswitchingofthestormorkenstim1r304wmutantintotheactivatedstate AT norbertmuller adualmechanismpromotesswitchingofthestormorkenstim1r304wmutantintotheactivatedstate AT christophromanin adualmechanismpromotesswitchingofthestormorkenstim1r304wmutantintotheactivatedstate AT marcfahrner dualmechanismpromotesswitchingofthestormorkenstim1r304wmutantintotheactivatedstate AT michaelstadlbauer dualmechanismpromotesswitchingofthestormorkenstim1r304wmutantintotheactivatedstate AT martinmuik dualmechanismpromotesswitchingofthestormorkenstim1r304wmutantintotheactivatedstate AT petrrathner dualmechanismpromotesswitchingofthestormorkenstim1r304wmutantintotheactivatedstate AT peterstathopulos dualmechanismpromotesswitchingofthestormorkenstim1r304wmutantintotheactivatedstate AT mitsuikura dualmechanismpromotesswitchingofthestormorkenstim1r304wmutantintotheactivatedstate AT norbertmuller dualmechanismpromotesswitchingofthestormorkenstim1r304wmutantintotheactivatedstate AT christophromanin dualmechanismpromotesswitchingofthestormorkenstim1r304wmutantintotheactivatedstate |