Novel free paclitaxel-loaded poly(L-γ-glutamylglutamine)–paclitaxel nanoparticles
Danbo Yang1, Sang Van2, Xinguo Jiang3, Lei Yu1,21Biomedical Engineering and Technology Institute, Institutes for Advanced Interdisciplinary Research, East China Normal University, Shanghai, People's Republic of China; 2Biomedical Group, Nitto Denko Technical Corporation, Oceanside, CA, U...
| Autors principals: | , , , |
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| Format: | Article |
| Idioma: | English |
| Publicat: |
Dove Medical Press
2011-01-01
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| Col·lecció: | International Journal of Nanomedicine |
| Accés en línia: | http://www.dovepress.com/novel-free-paclitaxel-loaded-polyl-gamma-glutamylglutaminendashpaclita-a5997 |
| _version_ | 1830270536048967680 |
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| author | Danbo Yang Sang Van Xinguo Jiang et al |
| author_facet | Danbo Yang Sang Van Xinguo Jiang et al |
| author_sort | Danbo Yang |
| collection | DOAJ |
| description | Danbo Yang1, Sang Van2, Xinguo Jiang3, Lei Yu1,21Biomedical Engineering and Technology Institute, Institutes for Advanced Interdisciplinary Research, East China Normal University, Shanghai, People's Republic of China; 2Biomedical Group, Nitto Denko Technical Corporation, Oceanside, CA, USA; 3School of Pharmacy, Fudan University, Shanghai, People's Republic of ChinaAbstract: The purpose of this study was to develop a novel formulation of paclitaxel (PTX) that would improve its therapeutic index. Here, we combined a concept of polymer–PTX drug conjugate with a concept of polymeric micelle drug delivery to form novel free PTX-loaded poly(L-γ-glutamylglutamine) (PGG)–PTX conjugate nanoparticles. The significance of this drug formulation emphasizes the simplicity, novelty, and flexibility of the method of forming nanoparticles that contain free PTX and conjugated PTX in the same drug delivery system. The results of effectively inhibiting tumor growth in mouse models demonstrated the feasibility of the nanoparticle formulation. The versatility and potential of this dual PTX drug delivery system can be explored with different drugs for different indications. Novel and simple formulations of PTX-loaded PGG–PTX nanoparticles could have important implications in translational medicines.Keywords: paclitaxel, polymeric micelle, poly(L-γ-glutamylglutamine)–paclitaxel, nanoconjugate, nanoparticles |
| first_indexed | 2024-12-18T22:49:09Z |
| format | Article |
| id | doaj.art-f3d2c1ce70a3477c98d98cb1fdd74c86 |
| institution | Directory Open Access Journal |
| issn | 1176-9114 1178-2013 |
| language | English |
| last_indexed | 2024-12-18T22:49:09Z |
| publishDate | 2011-01-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | International Journal of Nanomedicine |
| spelling | doaj.art-f3d2c1ce70a3477c98d98cb1fdd74c862022-12-21T20:48:54ZengDove Medical PressInternational Journal of Nanomedicine1176-91141178-20132011-01-012011default8591Novel free paclitaxel-loaded poly(L-γ-glutamylglutamine)–paclitaxel nanoparticlesDanbo YangSang VanXinguo Jianget alDanbo Yang1, Sang Van2, Xinguo Jiang3, Lei Yu1,21Biomedical Engineering and Technology Institute, Institutes for Advanced Interdisciplinary Research, East China Normal University, Shanghai, People's Republic of China; 2Biomedical Group, Nitto Denko Technical Corporation, Oceanside, CA, USA; 3School of Pharmacy, Fudan University, Shanghai, People's Republic of ChinaAbstract: The purpose of this study was to develop a novel formulation of paclitaxel (PTX) that would improve its therapeutic index. Here, we combined a concept of polymer–PTX drug conjugate with a concept of polymeric micelle drug delivery to form novel free PTX-loaded poly(L-γ-glutamylglutamine) (PGG)–PTX conjugate nanoparticles. The significance of this drug formulation emphasizes the simplicity, novelty, and flexibility of the method of forming nanoparticles that contain free PTX and conjugated PTX in the same drug delivery system. The results of effectively inhibiting tumor growth in mouse models demonstrated the feasibility of the nanoparticle formulation. The versatility and potential of this dual PTX drug delivery system can be explored with different drugs for different indications. Novel and simple formulations of PTX-loaded PGG–PTX nanoparticles could have important implications in translational medicines.Keywords: paclitaxel, polymeric micelle, poly(L-γ-glutamylglutamine)–paclitaxel, nanoconjugate, nanoparticleshttp://www.dovepress.com/novel-free-paclitaxel-loaded-polyl-gamma-glutamylglutaminendashpaclita-a5997 |
| spellingShingle | Danbo Yang Sang Van Xinguo Jiang et al Novel free paclitaxel-loaded poly(L-γ-glutamylglutamine)–paclitaxel nanoparticles International Journal of Nanomedicine |
| title | Novel free paclitaxel-loaded poly(L-γ-glutamylglutamine)–paclitaxel nanoparticles |
| title_full | Novel free paclitaxel-loaded poly(L-γ-glutamylglutamine)–paclitaxel nanoparticles |
| title_fullStr | Novel free paclitaxel-loaded poly(L-γ-glutamylglutamine)–paclitaxel nanoparticles |
| title_full_unstemmed | Novel free paclitaxel-loaded poly(L-γ-glutamylglutamine)–paclitaxel nanoparticles |
| title_short | Novel free paclitaxel-loaded poly(L-γ-glutamylglutamine)–paclitaxel nanoparticles |
| title_sort | novel free paclitaxel loaded poly l amp gamma glutamylglutamine amp ndash paclitaxel nanoparticles |
| url | http://www.dovepress.com/novel-free-paclitaxel-loaded-polyl-gamma-glutamylglutaminendashpaclita-a5997 |
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