Immunity and Its Effect on the Incidence of Multiple Organ Failure in Patients after the Heart Surgery
The purpose of the study is to identify the components of immunity, which might predict the development of multiple organ failure in patients after heart surgery.Material and methods. The study included 40 patients who were operated in cardiac surgery Department. The inclusion criteria were the pres...
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| Format: | Article |
| Language: | English |
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Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, Moscow, Russia
2019-09-01
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| Series: | Общая реаниматология |
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| Online Access: | https://www.reanimatology.com/rmt/article/view/1787 |
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| author | E. A. Partylova Yu. I. Petrishchev I. V. Kudryavtsev O. G. Malkova A. L. Levit |
| author_facet | E. A. Partylova Yu. I. Petrishchev I. V. Kudryavtsev O. G. Malkova A. L. Levit |
| author_sort | E. A. Partylova |
| collection | DOAJ |
| description | The purpose of the study is to identify the components of immunity, which might predict the development of multiple organ failure in patients after heart surgery.Material and methods. The study included 40 patients who were operated in cardiac surgery Department. The inclusion criteria were the presence of indications for cardiac surgery. The exclusion criteria were the presence of infective endocarditis in patients. Before the operation and after 24 hours we studied the blood level of leukocytes and lymphocytes. We analyzed the phenotype of immune cells using monoclonal antibodies, serum levels of procalcitonin and C3 and C4 complement components. All patients were evaluated for multiple organ disfunction (MOD) using the SOFA scale.The results showed that cardiac surgery leads to the development of MOD, statistically significant multidirectional changes in both quantitative and qualitative composition of all cells of the immune system, significant changes in the level of C3 and C4 components of the cascade of complement and plasma level of pro-calcitonin. ROC analysis was revealed that the relative content of monocytes is less than 7.1% of the number of leukocytes as well as the absolute content of monocytes with the CD14 + HLA-DR + phenotype less than 0.32_109/l in the preoperative period, and the C3 level of the complement component less than 0.52 g/l, as well as the maximum SOFA score in the postoperative period, were the best predictors of MOD after the procedures.Conclusion. The components of innate immunity make it possible to predict the complication of the cardiac surgery, earlier than the SOFA scale. |
| first_indexed | 2024-04-10T01:27:47Z |
| format | Article |
| id | doaj.art-f3d39900a39b4955a9e61d9eb2c43737 |
| institution | Directory Open Access Journal |
| issn | 1813-9779 2411-7110 |
| language | English |
| last_indexed | 2024-04-10T01:27:47Z |
| publishDate | 2019-09-01 |
| publisher | Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, Moscow, Russia |
| record_format | Article |
| series | Общая реаниматология |
| spelling | doaj.art-f3d39900a39b4955a9e61d9eb2c437372023-03-13T09:32:56ZengFederal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, Moscow, RussiaОбщая реаниматология1813-97792411-71102019-09-01154324110.15360/1813-9779-2019-4-32-411697Immunity and Its Effect on the Incidence of Multiple Organ Failure in Patients after the Heart SurgeryE. A. Partylova0Yu. I. Petrishchev1I. V. Kudryavtsev2O. G. Malkova3A. L. Levit4Свердловская Областная Клиническая Больница №1Свердловская Областная Клиническая Больница №1Институт экспериментальной медицины, Первый Санкт-Петербургский государственный медицинский университет им. И. П. Павлова Минздрава РоссииСвердловская Областная Клиническая Больница №1Свердловская Областная Клиническая Больница №1The purpose of the study is to identify the components of immunity, which might predict the development of multiple organ failure in patients after heart surgery.Material and methods. The study included 40 patients who were operated in cardiac surgery Department. The inclusion criteria were the presence of indications for cardiac surgery. The exclusion criteria were the presence of infective endocarditis in patients. Before the operation and after 24 hours we studied the blood level of leukocytes and lymphocytes. We analyzed the phenotype of immune cells using monoclonal antibodies, serum levels of procalcitonin and C3 and C4 complement components. All patients were evaluated for multiple organ disfunction (MOD) using the SOFA scale.The results showed that cardiac surgery leads to the development of MOD, statistically significant multidirectional changes in both quantitative and qualitative composition of all cells of the immune system, significant changes in the level of C3 and C4 components of the cascade of complement and plasma level of pro-calcitonin. ROC analysis was revealed that the relative content of monocytes is less than 7.1% of the number of leukocytes as well as the absolute content of monocytes with the CD14 + HLA-DR + phenotype less than 0.32_109/l in the preoperative period, and the C3 level of the complement component less than 0.52 g/l, as well as the maximum SOFA score in the postoperative period, were the best predictors of MOD after the procedures.Conclusion. The components of innate immunity make it possible to predict the complication of the cardiac surgery, earlier than the SOFA scale.https://www.reanimatology.com/rmt/article/view/1787моноцитыкомпоненты каскада комплементафенотип cd14+hla-dr+врожденный иммунитетsofa |
| spellingShingle | E. A. Partylova Yu. I. Petrishchev I. V. Kudryavtsev O. G. Malkova A. L. Levit Immunity and Its Effect on the Incidence of Multiple Organ Failure in Patients after the Heart Surgery Общая реаниматология моноциты компоненты каскада комплемента фенотип cd14+hla-dr+ врожденный иммунитет sofa |
| title | Immunity and Its Effect on the Incidence of Multiple Organ Failure in Patients after the Heart Surgery |
| title_full | Immunity and Its Effect on the Incidence of Multiple Organ Failure in Patients after the Heart Surgery |
| title_fullStr | Immunity and Its Effect on the Incidence of Multiple Organ Failure in Patients after the Heart Surgery |
| title_full_unstemmed | Immunity and Its Effect on the Incidence of Multiple Organ Failure in Patients after the Heart Surgery |
| title_short | Immunity and Its Effect on the Incidence of Multiple Organ Failure in Patients after the Heart Surgery |
| title_sort | immunity and its effect on the incidence of multiple organ failure in patients after the heart surgery |
| topic | моноциты компоненты каскада комплемента фенотип cd14+hla-dr+ врожденный иммунитет sofa |
| url | https://www.reanimatology.com/rmt/article/view/1787 |
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