Zebrafish as a Model for the Study of Lipid-Lowering Drug-Induced Myopathies
Drug-induced myopathies are classified as acquired myopathies caused by exogenous factors. These pathological conditions develop in patients without muscle disease and are triggered by a variety of medicaments, including lipid-lowering drugs (LLDs) such as statins, fibrates, and ezetimibe. Here we s...
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| Format: | Article |
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MDPI AG
2021-05-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/22/11/5654 |
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| author | Magda Dubińska-Magiera Marta Migocka-Patrzałek Damian Lewandowski Małgorzata Daczewska Krzysztof Jagla |
| author_facet | Magda Dubińska-Magiera Marta Migocka-Patrzałek Damian Lewandowski Małgorzata Daczewska Krzysztof Jagla |
| author_sort | Magda Dubińska-Magiera |
| collection | DOAJ |
| description | Drug-induced myopathies are classified as acquired myopathies caused by exogenous factors. These pathological conditions develop in patients without muscle disease and are triggered by a variety of medicaments, including lipid-lowering drugs (LLDs) such as statins, fibrates, and ezetimibe. Here we summarise the current knowledge gained via studies conducted using various models, such as cell lines and mammalian models, and compare them with the results obtained in zebrafish (<i>Danio rerio</i>) studies. Zebrafish have proven to be an excellent research tool for studying dyslipidaemias as a model of these pathological conditions. This system enables in-vivo characterization of drug and gene candidates to further the understanding of disease aetiology and develop new therapeutic strategies. Our review also considers important environmental issues arising from the indiscriminate use of LLDs worldwide. The widespread use and importance of drugs such as statins and fibrates justify the need for the meticulous study of their mechanism of action and the side effects they cause. |
| first_indexed | 2024-03-10T11:01:59Z |
| format | Article |
| id | doaj.art-f3d4cf85e2e0424fa5aff813357bfc16 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T11:01:59Z |
| publishDate | 2021-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-f3d4cf85e2e0424fa5aff813357bfc162023-11-21T21:29:44ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-05-012211565410.3390/ijms22115654Zebrafish as a Model for the Study of Lipid-Lowering Drug-Induced MyopathiesMagda Dubińska-Magiera0Marta Migocka-Patrzałek1Damian Lewandowski2Małgorzata Daczewska3Krzysztof Jagla4Department of Animal Developmental Biology, Faculty of Biological Sciences, University of Wrocław, Sienkiewicza 21, 50-335 Wrocław, PolandDepartment of Animal Developmental Biology, Faculty of Biological Sciences, University of Wrocław, Sienkiewicza 21, 50-335 Wrocław, PolandDepartment of Animal Developmental Biology, Faculty of Biological Sciences, University of Wrocław, Sienkiewicza 21, 50-335 Wrocław, PolandDepartment of Animal Developmental Biology, Faculty of Biological Sciences, University of Wrocław, Sienkiewicza 21, 50-335 Wrocław, PolandGenetics Reproduction and Development Institute (iGReD), INSERM 1103, CNRS 6293, University of Clermont Auvergne, 28 Place Henri Dunant, 63001 Clermont-Ferrand, FranceDrug-induced myopathies are classified as acquired myopathies caused by exogenous factors. These pathological conditions develop in patients without muscle disease and are triggered by a variety of medicaments, including lipid-lowering drugs (LLDs) such as statins, fibrates, and ezetimibe. Here we summarise the current knowledge gained via studies conducted using various models, such as cell lines and mammalian models, and compare them with the results obtained in zebrafish (<i>Danio rerio</i>) studies. Zebrafish have proven to be an excellent research tool for studying dyslipidaemias as a model of these pathological conditions. This system enables in-vivo characterization of drug and gene candidates to further the understanding of disease aetiology and develop new therapeutic strategies. Our review also considers important environmental issues arising from the indiscriminate use of LLDs worldwide. The widespread use and importance of drugs such as statins and fibrates justify the need for the meticulous study of their mechanism of action and the side effects they cause.https://www.mdpi.com/1422-0067/22/11/5654statinsfibratesezetimibezebrafishmusclemyotoxicity |
| spellingShingle | Magda Dubińska-Magiera Marta Migocka-Patrzałek Damian Lewandowski Małgorzata Daczewska Krzysztof Jagla Zebrafish as a Model for the Study of Lipid-Lowering Drug-Induced Myopathies International Journal of Molecular Sciences statins fibrates ezetimibe zebrafish muscle myotoxicity |
| title | Zebrafish as a Model for the Study of Lipid-Lowering Drug-Induced Myopathies |
| title_full | Zebrafish as a Model for the Study of Lipid-Lowering Drug-Induced Myopathies |
| title_fullStr | Zebrafish as a Model for the Study of Lipid-Lowering Drug-Induced Myopathies |
| title_full_unstemmed | Zebrafish as a Model for the Study of Lipid-Lowering Drug-Induced Myopathies |
| title_short | Zebrafish as a Model for the Study of Lipid-Lowering Drug-Induced Myopathies |
| title_sort | zebrafish as a model for the study of lipid lowering drug induced myopathies |
| topic | statins fibrates ezetimibe zebrafish muscle myotoxicity |
| url | https://www.mdpi.com/1422-0067/22/11/5654 |
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