Seroprevalence and risk factors of brucellosis among slaughtered indigenous cattle, abattoir personnel and pregnant women in Ngaoundéré, Cameroon
Abstract Background Brucellosis is a neglected debilitating zoonosis with a high prevalence in many developing countries. Bovine brucellosis is widespread in Cameroon but the epidemiological situation of human brucellosis is not known. A cross sectional study was carried to determine the seroprevale...
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BMC
2018-12-01
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| Series: | BMC Infectious Diseases |
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| Online Access: | http://link.springer.com/article/10.1186/s12879-018-3522-x |
| _version_ | 1819083278199554048 |
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| author | Julius Awah-Ndukum Mohamed Moctar Mouliom Mouiche Lucy Kouonmo-Ngnoyum Houli Nicolas Bayang Tanyi Kingsley Manchang Rodrigue Simonet Namegni Poueme Justin Kouamo Victor Ngu-Ngwa Emmanuel Assana Kameni Jean Marc Feussom André Pagnah Zoli |
| author_facet | Julius Awah-Ndukum Mohamed Moctar Mouliom Mouiche Lucy Kouonmo-Ngnoyum Houli Nicolas Bayang Tanyi Kingsley Manchang Rodrigue Simonet Namegni Poueme Justin Kouamo Victor Ngu-Ngwa Emmanuel Assana Kameni Jean Marc Feussom André Pagnah Zoli |
| author_sort | Julius Awah-Ndukum |
| collection | DOAJ |
| description | Abstract Background Brucellosis is a neglected debilitating zoonosis with a high prevalence in many developing countries. Bovine brucellosis is widespread in Cameroon but the epidemiological situation of human brucellosis is not known. A cross sectional study was carried to determine the seroprevalence and factors associated with bovine and human Brucellosis among abattoir personnel and pregnant women in Ngaoundéré, Cameroon. Methods Serum sample from 590 abattoir cattle and 816 plausible occupational risk and vulnerable humans to brucellosis (107 abattoir personnel and 709 pregnant women) were collected and screened for anti-brucella antibodies using Rose Bengal Plate Test (RBPT) and ELISA tests. Structured questionnaires were used to collect data on socio-demographics and risk-factors. The differences in proportions between seropositive and seronegative reactors were tested using odds-ratio and χ2tests. Results Bovine brucellosis seroprevalence was at 3.40% (n = 590; 3.4% for RBPT, 5.93% for i-ELISA). Human Brucella seroprevalence was at 5.6% among abattoir personnel (n = 107; 5.6% for RBPT, 12.15% for Brucella IgG ELISA) and 0.28% in pregnant women (n = 709; both tests). Breed (P < 0.00001) was associated with increased risk of brucellosis in cattle and the seroprevalence was highest among the Djafoun (OR = 16.67, 95%CI: 4.49–28.85) and Akou (OR = 16.96, 95% CI: 0.10–23.91) cattle compared to the other breeds. There was a moderate positive correlation (R2 = 0.5025) of Brucella IgG concentrations (> 200 U/ml) and clinical data for Brucella IgG ELISA seropositive humans. Several potential factors were associated (P > 0.05) with increased risk of human brucellosis seroprevalence among the abattoir personnel. The abattoir personnel were essentially males; the seropositive respondents were male and did not use protective equipment at work. Handling of foetus and uterine contents (OR = 13.00, 95%CI: 1.51–111.88) was associated with increased risk of human brucellosis. Conclusions Antibrucella antibodies are prevalent in cattle (3.40%), among abattoir personnel (5.60%) and in pregnant women (0.28%) in Ngaoundéré, Cameroon. The study reports the first evidence of human brucellosis in Cameroon and therefore, an indication of a real public health problem. Public awareness campaigns and health education especially among livestock professional and in agropastoral communities should be highlighted to disseminate knowledge, associated risk factors and control measures of brucellosis. |
| first_indexed | 2024-12-21T20:30:01Z |
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| institution | Directory Open Access Journal |
| issn | 1471-2334 |
| language | English |
| last_indexed | 2024-12-21T20:30:01Z |
| publishDate | 2018-12-01 |
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| series | BMC Infectious Diseases |
| spelling | doaj.art-f3d7bb571e8d4f51a341dad09e91f3472022-12-21T18:51:15ZengBMCBMC Infectious Diseases1471-23342018-12-0118111310.1186/s12879-018-3522-xSeroprevalence and risk factors of brucellosis among slaughtered indigenous cattle, abattoir personnel and pregnant women in Ngaoundéré, CameroonJulius Awah-Ndukum0Mohamed Moctar Mouliom Mouiche1Lucy Kouonmo-Ngnoyum2Houli Nicolas Bayang3Tanyi Kingsley Manchang4Rodrigue Simonet Namegni Poueme5Justin Kouamo6Victor Ngu-Ngwa7Emmanuel Assana8Kameni Jean Marc Feussom9André Pagnah Zoli10School of Veterinary Medicine and Sciences, University of NgaoundéréSchool of Veterinary Medicine and Sciences, University of NgaoundéréSchool of Veterinary Medicine and Sciences, University of NgaoundéréInstitute of Agricultural Research for Development, Veterinary Research Laboratory, Wakwa Regional CenterInstitute of Agricultural Research for Development, Veterinary Research Laboratory, Wakwa Regional CenterNational Veterinary LaboratorySchool of Veterinary Medicine and Sciences, University of NgaoundéréSchool of Veterinary Medicine and Sciences, University of NgaoundéréSchool of Veterinary Medicine and Sciences, University of NgaoundéréEpidemio-Surveillance Service, Ministry of Livestock, Fisheries and Animal Industries YaoundéSchool of Veterinary Medicine and Sciences, University of NgaoundéréAbstract Background Brucellosis is a neglected debilitating zoonosis with a high prevalence in many developing countries. Bovine brucellosis is widespread in Cameroon but the epidemiological situation of human brucellosis is not known. A cross sectional study was carried to determine the seroprevalence and factors associated with bovine and human Brucellosis among abattoir personnel and pregnant women in Ngaoundéré, Cameroon. Methods Serum sample from 590 abattoir cattle and 816 plausible occupational risk and vulnerable humans to brucellosis (107 abattoir personnel and 709 pregnant women) were collected and screened for anti-brucella antibodies using Rose Bengal Plate Test (RBPT) and ELISA tests. Structured questionnaires were used to collect data on socio-demographics and risk-factors. The differences in proportions between seropositive and seronegative reactors were tested using odds-ratio and χ2tests. Results Bovine brucellosis seroprevalence was at 3.40% (n = 590; 3.4% for RBPT, 5.93% for i-ELISA). Human Brucella seroprevalence was at 5.6% among abattoir personnel (n = 107; 5.6% for RBPT, 12.15% for Brucella IgG ELISA) and 0.28% in pregnant women (n = 709; both tests). Breed (P < 0.00001) was associated with increased risk of brucellosis in cattle and the seroprevalence was highest among the Djafoun (OR = 16.67, 95%CI: 4.49–28.85) and Akou (OR = 16.96, 95% CI: 0.10–23.91) cattle compared to the other breeds. There was a moderate positive correlation (R2 = 0.5025) of Brucella IgG concentrations (> 200 U/ml) and clinical data for Brucella IgG ELISA seropositive humans. Several potential factors were associated (P > 0.05) with increased risk of human brucellosis seroprevalence among the abattoir personnel. The abattoir personnel were essentially males; the seropositive respondents were male and did not use protective equipment at work. Handling of foetus and uterine contents (OR = 13.00, 95%CI: 1.51–111.88) was associated with increased risk of human brucellosis. Conclusions Antibrucella antibodies are prevalent in cattle (3.40%), among abattoir personnel (5.60%) and in pregnant women (0.28%) in Ngaoundéré, Cameroon. The study reports the first evidence of human brucellosis in Cameroon and therefore, an indication of a real public health problem. Public awareness campaigns and health education especially among livestock professional and in agropastoral communities should be highlighted to disseminate knowledge, associated risk factors and control measures of brucellosis.http://link.springer.com/article/10.1186/s12879-018-3522-xBrucellosisCattleHumansPrevalenceRisk factorsNgaoundéré-Cameroon |
| spellingShingle | Julius Awah-Ndukum Mohamed Moctar Mouliom Mouiche Lucy Kouonmo-Ngnoyum Houli Nicolas Bayang Tanyi Kingsley Manchang Rodrigue Simonet Namegni Poueme Justin Kouamo Victor Ngu-Ngwa Emmanuel Assana Kameni Jean Marc Feussom André Pagnah Zoli Seroprevalence and risk factors of brucellosis among slaughtered indigenous cattle, abattoir personnel and pregnant women in Ngaoundéré, Cameroon BMC Infectious Diseases Brucellosis Cattle Humans Prevalence Risk factors Ngaoundéré-Cameroon |
| title | Seroprevalence and risk factors of brucellosis among slaughtered indigenous cattle, abattoir personnel and pregnant women in Ngaoundéré, Cameroon |
| title_full | Seroprevalence and risk factors of brucellosis among slaughtered indigenous cattle, abattoir personnel and pregnant women in Ngaoundéré, Cameroon |
| title_fullStr | Seroprevalence and risk factors of brucellosis among slaughtered indigenous cattle, abattoir personnel and pregnant women in Ngaoundéré, Cameroon |
| title_full_unstemmed | Seroprevalence and risk factors of brucellosis among slaughtered indigenous cattle, abattoir personnel and pregnant women in Ngaoundéré, Cameroon |
| title_short | Seroprevalence and risk factors of brucellosis among slaughtered indigenous cattle, abattoir personnel and pregnant women in Ngaoundéré, Cameroon |
| title_sort | seroprevalence and risk factors of brucellosis among slaughtered indigenous cattle abattoir personnel and pregnant women in ngaoundere cameroon |
| topic | Brucellosis Cattle Humans Prevalence Risk factors Ngaoundéré-Cameroon |
| url | http://link.springer.com/article/10.1186/s12879-018-3522-x |
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