Rapid and Economical Drug-Eluting IOL Preparation via Thermoresponsive Agarose Coating for Effective Posterior Capsular Opacification Prevention
Posterior capsular opacification (PCO), the highest incidence complication after cataract surgery, is mainly due to the attachment, proliferation, and migration of the residual lens epithelial cells (LECs). Although the drug-eluting IOLs have been proved to be an effective way to prevent PCO inciden...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-08-01
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| Series: | Frontiers in Bioengineering and Biotechnology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fbioe.2022.930540/full |
| _version_ | 1811313695624527872 |
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| author | Siqi Chen Chen Qin Qiuna Fang Lan Duo Mengting Wang Zhennv Deng Hao Chen Quankui Lin |
| author_facet | Siqi Chen Chen Qin Qiuna Fang Lan Duo Mengting Wang Zhennv Deng Hao Chen Quankui Lin |
| author_sort | Siqi Chen |
| collection | DOAJ |
| description | Posterior capsular opacification (PCO), the highest incidence complication after cataract surgery, is mainly due to the attachment, proliferation, and migration of the residual lens epithelial cells (LECs). Although the drug-eluting IOLs have been proved to be an effective way to prevent PCO incidence, its preparations are time consuming and require tedious preparation steps. Herein, the thermoreversible agarose is adopted to prepare drug-eluting IOL. Such functional coating can be obtained easily by simple immersion in the antiproliferative drug containing hot agarose and taken out for cooling, which not only does not affect the optical property but also can effectively decrease the PCO incidence after intraocular implantation. As a result, the proposed agarose coating provides a rapid and economical alternative of drug-eluting IOL fabrication for PCO prevention. |
| first_indexed | 2024-04-13T10:58:16Z |
| format | Article |
| id | doaj.art-f3d9a52de0c64053a2f8c1cae4832e8d |
| institution | Directory Open Access Journal |
| issn | 2296-4185 |
| language | English |
| last_indexed | 2024-04-13T10:58:16Z |
| publishDate | 2022-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Bioengineering and Biotechnology |
| spelling | doaj.art-f3d9a52de0c64053a2f8c1cae4832e8d2022-12-22T02:49:28ZengFrontiers Media S.A.Frontiers in Bioengineering and Biotechnology2296-41852022-08-011010.3389/fbioe.2022.930540930540Rapid and Economical Drug-Eluting IOL Preparation via Thermoresponsive Agarose Coating for Effective Posterior Capsular Opacification PreventionSiqi ChenChen QinQiuna FangLan DuoMengting WangZhennv DengHao ChenQuankui LinPosterior capsular opacification (PCO), the highest incidence complication after cataract surgery, is mainly due to the attachment, proliferation, and migration of the residual lens epithelial cells (LECs). Although the drug-eluting IOLs have been proved to be an effective way to prevent PCO incidence, its preparations are time consuming and require tedious preparation steps. Herein, the thermoreversible agarose is adopted to prepare drug-eluting IOL. Such functional coating can be obtained easily by simple immersion in the antiproliferative drug containing hot agarose and taken out for cooling, which not only does not affect the optical property but also can effectively decrease the PCO incidence after intraocular implantation. As a result, the proposed agarose coating provides a rapid and economical alternative of drug-eluting IOL fabrication for PCO prevention.https://www.frontiersin.org/articles/10.3389/fbioe.2022.930540/fullagarosesurface modificationdrug-eluting coatingintraocular lensposterior capsular opacification |
| spellingShingle | Siqi Chen Chen Qin Qiuna Fang Lan Duo Mengting Wang Zhennv Deng Hao Chen Quankui Lin Rapid and Economical Drug-Eluting IOL Preparation via Thermoresponsive Agarose Coating for Effective Posterior Capsular Opacification Prevention Frontiers in Bioengineering and Biotechnology agarose surface modification drug-eluting coating intraocular lens posterior capsular opacification |
| title | Rapid and Economical Drug-Eluting IOL Preparation via Thermoresponsive Agarose Coating for Effective Posterior Capsular Opacification Prevention |
| title_full | Rapid and Economical Drug-Eluting IOL Preparation via Thermoresponsive Agarose Coating for Effective Posterior Capsular Opacification Prevention |
| title_fullStr | Rapid and Economical Drug-Eluting IOL Preparation via Thermoresponsive Agarose Coating for Effective Posterior Capsular Opacification Prevention |
| title_full_unstemmed | Rapid and Economical Drug-Eluting IOL Preparation via Thermoresponsive Agarose Coating for Effective Posterior Capsular Opacification Prevention |
| title_short | Rapid and Economical Drug-Eluting IOL Preparation via Thermoresponsive Agarose Coating for Effective Posterior Capsular Opacification Prevention |
| title_sort | rapid and economical drug eluting iol preparation via thermoresponsive agarose coating for effective posterior capsular opacification prevention |
| topic | agarose surface modification drug-eluting coating intraocular lens posterior capsular opacification |
| url | https://www.frontiersin.org/articles/10.3389/fbioe.2022.930540/full |
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