Sprouty3 and Sprouty4, Two Members of a Family Known to Inhibit FGF-Mediated Signaling, Exert Opposing Roles on Proliferation and Migration of Glioblastoma-Derived Cells

Sprouty3 and Sprouty4, Two Members of a Family Known to Inhibit FGF-Mediated Signaling, Exert Opposing Roles on Proliferation and Migration of Glioblastoma-Derived Cells

Dysregulation of receptor tyrosine kinase-induced pathways is a critical step driving the oncogenic potential of brain cancer. In this study, we investigated the role of two members of the Sprouty (Spry) family in brain cancer-derived cell lines. Using immunoblot analyses we found essential differen...

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Bibliographic Details
Main Authors: Burcu Emine Celik-Selvi, Astrid Stütz, Christoph-Erik Mayer, Jihen Salhi, Gerald Siegwart, Hedwig Sutterlüty
Format: Article
Language:English
Published: MDPI AG 2019-08-01
Series:Cells
Subjects:
Sprouty proteins
brain cancer
FGF-mediated signaling
tumor suppressor
tumor promoter
Online Access:https://www.mdpi.com/2073-4409/8/8/808

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