RNA Polymerase II transcription independent of TBP in murine embryonic stem cells

RNA Polymerase II transcription independent of TBP in murine embryonic stem cells

Transcription by RNA Polymerase II (Pol II) is initiated by the hierarchical assembly of the pre-initiation complex onto promoter DNA. Decades of research have shown that the TATA-box binding protein (TBP) is essential for Pol II loading and initiation. Here, we report instead that acute depletion o...

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Bibliographic Details
Main Authors: James ZJ Kwan, Thomas F Nguyen, Anuli C Uzozie, Marek A Budzynski, Jieying Cui, Joseph MC Lee, Filip Van Petegem, Philipp F Lange, Sheila S Teves
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2023-03-01
Series:eLife
Subjects:
embryonic stem cells
transcription
degron
genomics
Online Access:https://elifesciences.org/articles/83810

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