An Audit of the Length of Bone Marrow Trephine Biopsy in Adult Patients: A Cross-sectional Study
Introduction: A bone marrow trephine biopsy is a minor surgical procedure used to diagnose various haematological and non haematological diseases, such as leukaemia, multiple myeloma, and parasitic disorders like histoplasmosis and leishmaniasis. It is often performed alongside bone marrow aspi...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
JCDR Research and Publications Private Limited
2023-08-01
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| Series: | Journal of Clinical and Diagnostic Research |
| Subjects: | |
| Online Access: | https://www.jcdr.net/articles/PDF/18352/64980_CE[Ra1]_F[SK]_QC(AN_OM)_PF1(AG_SS)_PFA(AG_KM)_PN(KM).pdf |
| Summary: | Introduction: A bone marrow trephine biopsy is a minor
surgical procedure used to diagnose various haematological
and non haematological diseases, such as leukaemia, multiple
myeloma, and parasitic disorders like histoplasmosis and
leishmaniasis. It is often performed alongside bone marrow
aspiration to gather additional information about cellularity, the
arrangement of marrow components, and the presence of focal
diseases. According to the World Health Organisation (WHO),
the recommended minimum adequate length for a trephine
biopsy is ≥1.5 cm (before processing).
Aim: To conduct an audit of trephine biopsy lengths and assess
their diagnostic utility among adult patients.
Materials and Methods: This cross-sectional study analysed
all bone marrow biopsies from adult patients received at the
Department of Pathology, Christian Medical College and Hospital
in Ludhiana, Punjab, India, over a three-year period (January
2019 to December 2021). The biopsies were categorised into
three groups based on their length at the time of grossing:
Group A (≥1.5 cm), Group B (1-1.4 cm), and Group C (0.5-0.9
cm). The length of each trephine biopsy was recorded and its
diagnostic usefulness was evaluated.
Results: The study included 1,155 trephine biopsies performed
over the three-year period. Out of these, 1042, 97, and 16
biopsies were allocated to Groups A, B, and C, respectively.
Biopsies meeting the recommended length (>1.5 cm) accounted
for 90.2% of the cases. Longer biopsies were associated with
a higher rate of conclusive diagnosis compared to shorter
biopsies (p-value=0.02). However, when comparing Groups A
and B individually, no significant difference was observed in
terms of the conclusive diagnosis (p-value=0.9).
Conclusion: Trephine biopsy is a vital tool for diagnosing
haematological disorders, particularly focal lesions. Obtaining
longer trephine biopsies should be emphasised, as they
contribute to a more definitive diagnosis. |
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| ISSN: | 2249-782X 0973-709X |