Consumption of artificially-sweetened soft drinks in pregnancy and risk of child asthma and allergic rhinitis.
BACKGROUND: Past evidence has suggested a role of artificial sweeteners in allergic disease; yet, the evidence has been inconsistent and unclear. OBJECTIVE: To examine relation of intake of artificially-sweetened beverages during pregnancy with child asthma and allergic rhinitis at 18 months and 7 y...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2013-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC3584110?pdf=render |
| _version_ | 1818110192059940864 |
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| author | Ekaterina Maslova Marin Strøm Sjurdur F Olsen Thorhallur I Halldorsson |
| author_facet | Ekaterina Maslova Marin Strøm Sjurdur F Olsen Thorhallur I Halldorsson |
| author_sort | Ekaterina Maslova |
| collection | DOAJ |
| description | BACKGROUND: Past evidence has suggested a role of artificial sweeteners in allergic disease; yet, the evidence has been inconsistent and unclear. OBJECTIVE: To examine relation of intake of artificially-sweetened beverages during pregnancy with child asthma and allergic rhinitis at 18 months and 7 years. METHODS: We analyzed data from 60,466 women enrolled during pregnancy in the prospective longitudinal Danish National Birth Cohort between 1996 and 2003. At the 25th week of gestation we administered a validated Food Frequency Questionnaire which asked in detail about intake of artificially-sweetened soft drinks. At 18 months, we evaluated child asthma using interview data. We also assessed asthma and allergic rhinitis through a questionnaire at age 7 and by using national registries. Current asthma was defined as self-reported asthma diagnosis and wheeze in the past 12 months. We examined the relation between intake of artificially-sweetened soft drinks and child allergic disease outcomes and present here odds ratios with 95% CI comparing daily vs. no intake. RESULTS: At 18 months, we found that mothers who consumed more artificially-sweetened non-carbonated soft drinks were 1.23 (95% CI: 1.13, 1.33) times more likely to report a child asthma diagnosis compared to non-consumers. Similar results were found for child wheeze. Consumers of artificially-sweetened carbonated drinks were more likely to have a child asthma diagnosis in the patient (1.30, 95% CI: 1.01, 1.66) and medication (1.13, 95% CI: 0.98, 1.29) registry, as well as self-reported allergic rhinitis (1.31, 95% CI: 0.98, 1.74) during the first 7 years of follow-up. We found no associations for sugar-sweetened soft drinks. CONCLUSION: Carbonated artificially-sweetened soft drinks were associated with registry-based asthma and self-reported allergic rhinitis, while early childhood outcomes were related to non-carbonated soft drinks. These results suggest that consumption of artificially-sweetened soft drinks during pregnancy may play a role in offspring allergic disease development. |
| first_indexed | 2024-12-11T02:43:14Z |
| format | Article |
| id | doaj.art-f3ddbf462e4f4d4390211ff9e9fb89b7 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-11T02:43:14Z |
| publishDate | 2013-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-f3ddbf462e4f4d4390211ff9e9fb89b72022-12-22T01:23:32ZengPublic Library of Science (PLoS)PLoS ONE1932-62032013-01-0182e5726110.1371/journal.pone.0057261Consumption of artificially-sweetened soft drinks in pregnancy and risk of child asthma and allergic rhinitis.Ekaterina MaslovaMarin StrømSjurdur F OlsenThorhallur I HalldorssonBACKGROUND: Past evidence has suggested a role of artificial sweeteners in allergic disease; yet, the evidence has been inconsistent and unclear. OBJECTIVE: To examine relation of intake of artificially-sweetened beverages during pregnancy with child asthma and allergic rhinitis at 18 months and 7 years. METHODS: We analyzed data from 60,466 women enrolled during pregnancy in the prospective longitudinal Danish National Birth Cohort between 1996 and 2003. At the 25th week of gestation we administered a validated Food Frequency Questionnaire which asked in detail about intake of artificially-sweetened soft drinks. At 18 months, we evaluated child asthma using interview data. We also assessed asthma and allergic rhinitis through a questionnaire at age 7 and by using national registries. Current asthma was defined as self-reported asthma diagnosis and wheeze in the past 12 months. We examined the relation between intake of artificially-sweetened soft drinks and child allergic disease outcomes and present here odds ratios with 95% CI comparing daily vs. no intake. RESULTS: At 18 months, we found that mothers who consumed more artificially-sweetened non-carbonated soft drinks were 1.23 (95% CI: 1.13, 1.33) times more likely to report a child asthma diagnosis compared to non-consumers. Similar results were found for child wheeze. Consumers of artificially-sweetened carbonated drinks were more likely to have a child asthma diagnosis in the patient (1.30, 95% CI: 1.01, 1.66) and medication (1.13, 95% CI: 0.98, 1.29) registry, as well as self-reported allergic rhinitis (1.31, 95% CI: 0.98, 1.74) during the first 7 years of follow-up. We found no associations for sugar-sweetened soft drinks. CONCLUSION: Carbonated artificially-sweetened soft drinks were associated with registry-based asthma and self-reported allergic rhinitis, while early childhood outcomes were related to non-carbonated soft drinks. These results suggest that consumption of artificially-sweetened soft drinks during pregnancy may play a role in offspring allergic disease development.http://europepmc.org/articles/PMC3584110?pdf=render |
| spellingShingle | Ekaterina Maslova Marin Strøm Sjurdur F Olsen Thorhallur I Halldorsson Consumption of artificially-sweetened soft drinks in pregnancy and risk of child asthma and allergic rhinitis. PLoS ONE |
| title | Consumption of artificially-sweetened soft drinks in pregnancy and risk of child asthma and allergic rhinitis. |
| title_full | Consumption of artificially-sweetened soft drinks in pregnancy and risk of child asthma and allergic rhinitis. |
| title_fullStr | Consumption of artificially-sweetened soft drinks in pregnancy and risk of child asthma and allergic rhinitis. |
| title_full_unstemmed | Consumption of artificially-sweetened soft drinks in pregnancy and risk of child asthma and allergic rhinitis. |
| title_short | Consumption of artificially-sweetened soft drinks in pregnancy and risk of child asthma and allergic rhinitis. |
| title_sort | consumption of artificially sweetened soft drinks in pregnancy and risk of child asthma and allergic rhinitis |
| url | http://europepmc.org/articles/PMC3584110?pdf=render |
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