The Effect of Long-Running Severe Selenium-Deficiency on the Amount of Iron and Zinc in the Organs of Rats

The amounts of selenium (Se), iron (Fe), and zinc (Zn) in the liver, kidney, and spleen as a function of age of rats measured using instrumental neutron activation analysis were compared between Se-deficient (SeD) rats and normal rats. The SeD model rats can live for more than 50 weeks. The effect o...

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Bibliographic Details
Main Authors: Atsushi Hisamatsu, Iori Ui, Aya Okajo, Marie Ariyoshi, Sachiyo Terada, Ken-ichiro Matsumoto, Kazutoyo Endo
Format: Article
Language:English
Published: MDPI AG 2009-11-01
Series:Molecules
Subjects:
Online Access:http://www.mdpi.com/1420-3049/14/11/4440/
Description
Summary:The amounts of selenium (Se), iron (Fe), and zinc (Zn) in the liver, kidney, and spleen as a function of age of rats measured using instrumental neutron activation analysis were compared between Se-deficient (SeD) rats and normal rats. The SeD model rats can live for more than 50 weeks. The effect of Se-deficinecy in rats might be weak, compared to the marked malfunction of GSH-Px. The SeD rats can be considered as a model of nonlethal chronic oxidative stress. Fluctuations of Fe and Zn in the liver of Se-deficient rats were observed. The amount of redox-relating minerals, such as Fe and Zn, in SeD rat organs is changeable depending on the age.
ISSN:1420-3049