Factors Associated With Low Lean Mass in Early Rheumatoid Arthritis: A Cross- Sectional Study
<b> </b><i>Background and Objectives</i>: The aim of the study was to evaluate body composition (BC) of rheumatoid arthritis (RA) patients at disease onset compared to population controls focusing on the associations between low lean mass and disease specific parameters, nutr...
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| Format: | Article |
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MDPI AG
2019-11-01
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| Series: | Medicina |
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| Online Access: | https://www.mdpi.com/1010-660X/55/11/730 |
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| author | Raili Müller Mart Kull Kaja Põlluste Annika Valner Margus Lember Riina Kallikorm |
| author_facet | Raili Müller Mart Kull Kaja Põlluste Annika Valner Margus Lember Riina Kallikorm |
| author_sort | Raili Müller |
| collection | DOAJ |
| description | <b> </b><i>Background and Objectives</i>: The aim of the study was to evaluate body composition (BC) of rheumatoid arthritis (RA) patients at disease onset compared to population controls focusing on the associations between low lean mass and disease specific parameters, nutritional factors and physical activity.<i> </i><i>Materials and Methods</i>: 91 patients with early rheumatoid arthritis (ERA) (72% female) and 328 control subjects (54% female) were studied. BC- lean and fat mass parameters were measured with a Lunar Prodigy Dual Energy X-Ray Absorptiometry (DXA) machine. The prevalence, age and gender adjusted odds ratios of having low lean mass and overfat, associations between nutrition, physical activity, and ERA disease specific parameters and the presence of low lean mass were evaluated.<i> Results</i>: We found that the BC of patients with recent onset RA differs from control subjects—ERA patients had a higher mean body fat percentage (BFP) and lower appendicular lean mass (ALM). 41.8% of the ERA patients and 19.8% of the controls were classified as having low lean mass adjusted OR 3.3 (95% C.I. 1.9−5.5, <i>p</i> < 0.001). 68.1% of the ERA subjects and 47.3% of the controls were overfat (adjusted OR 1.9 (95% C.I. 1.1−3.3, <i>p</i> = 0.02)) and the adjusted odds of having both low lean mass and overfat were 4.4 times higher (26.4% vs. 7.0% 95% C.I. 2.3−8.4, <i>p</i> < 0.001) among the ERA group. Higher ESR (OR 1.03, C.I.1.002−1.051, <i>p</i> = 0.03), CRP (OR 1.03, C.I. 1.002−1.061, <i>p</i> = 0.04), lower protein intake (OR 0.98 C.I. 0.96−0.99, <i>p</i> = 0.04), corticosteroid usage (OR 3.71 C.I. 1.4−9.9, <i>p</i> < 0.01) and lower quality of life (higher HAQ score OR 2.41 C.I. 1.24−4.65, <i>p</i> < 0.01) were associated with having low lean mass in the ERA group (adjusted to age and gender). <i>Conclusions</i>: Patients with early RA have lower appendicular lean mass and higher body fat percentage compared to healthy controls. Loss of lean mass in early RA is associated with elevated inflammatory markers inducing catabolism, lower protein intake and also with GCS treatment. |
| first_indexed | 2024-03-12T09:22:45Z |
| format | Article |
| id | doaj.art-f3e0b0139030455bb9f0d85cf5d241a7 |
| institution | Directory Open Access Journal |
| issn | 1010-660X |
| language | English |
| last_indexed | 2024-03-12T09:22:45Z |
| publishDate | 2019-11-01 |
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| series | Medicina |
| spelling | doaj.art-f3e0b0139030455bb9f0d85cf5d241a72023-09-02T14:26:33ZengMDPI AGMedicina1010-660X2019-11-01551173010.3390/medicina55110730medicina55110730Factors Associated With Low Lean Mass in Early Rheumatoid Arthritis: A Cross- Sectional StudyRaili Müller0Mart Kull1Kaja Põlluste2Annika Valner3Margus Lember4Riina Kallikorm5Institute of Clinical Medicine, Tartu University, 50090 Tartu, EstoniaInstitute of Clinical Medicine, Tartu University, 50090 Tartu, EstoniaInstitute of Clinical Medicine, Tartu University, 50090 Tartu, EstoniaInstitute of Clinical Medicine, Tartu University, 50090 Tartu, EstoniaInstitute of Clinical Medicine, Tartu University, 50090 Tartu, EstoniaInstitute of Clinical Medicine, Tartu University, 50090 Tartu, Estonia<b> </b><i>Background and Objectives</i>: The aim of the study was to evaluate body composition (BC) of rheumatoid arthritis (RA) patients at disease onset compared to population controls focusing on the associations between low lean mass and disease specific parameters, nutritional factors and physical activity.<i> </i><i>Materials and Methods</i>: 91 patients with early rheumatoid arthritis (ERA) (72% female) and 328 control subjects (54% female) were studied. BC- lean and fat mass parameters were measured with a Lunar Prodigy Dual Energy X-Ray Absorptiometry (DXA) machine. The prevalence, age and gender adjusted odds ratios of having low lean mass and overfat, associations between nutrition, physical activity, and ERA disease specific parameters and the presence of low lean mass were evaluated.<i> Results</i>: We found that the BC of patients with recent onset RA differs from control subjects—ERA patients had a higher mean body fat percentage (BFP) and lower appendicular lean mass (ALM). 41.8% of the ERA patients and 19.8% of the controls were classified as having low lean mass adjusted OR 3.3 (95% C.I. 1.9−5.5, <i>p</i> < 0.001). 68.1% of the ERA subjects and 47.3% of the controls were overfat (adjusted OR 1.9 (95% C.I. 1.1−3.3, <i>p</i> = 0.02)) and the adjusted odds of having both low lean mass and overfat were 4.4 times higher (26.4% vs. 7.0% 95% C.I. 2.3−8.4, <i>p</i> < 0.001) among the ERA group. Higher ESR (OR 1.03, C.I.1.002−1.051, <i>p</i> = 0.03), CRP (OR 1.03, C.I. 1.002−1.061, <i>p</i> = 0.04), lower protein intake (OR 0.98 C.I. 0.96−0.99, <i>p</i> = 0.04), corticosteroid usage (OR 3.71 C.I. 1.4−9.9, <i>p</i> < 0.01) and lower quality of life (higher HAQ score OR 2.41 C.I. 1.24−4.65, <i>p</i> < 0.01) were associated with having low lean mass in the ERA group (adjusted to age and gender). <i>Conclusions</i>: Patients with early RA have lower appendicular lean mass and higher body fat percentage compared to healthy controls. Loss of lean mass in early RA is associated with elevated inflammatory markers inducing catabolism, lower protein intake and also with GCS treatment.https://www.mdpi.com/1010-660X/55/11/730rheumatoid arthritisearly arthritisbody compositionsarcopenialean mass |
| spellingShingle | Raili Müller Mart Kull Kaja Põlluste Annika Valner Margus Lember Riina Kallikorm Factors Associated With Low Lean Mass in Early Rheumatoid Arthritis: A Cross- Sectional Study Medicina rheumatoid arthritis early arthritis body composition sarcopenia lean mass |
| title | Factors Associated With Low Lean Mass in Early Rheumatoid Arthritis: A Cross- Sectional Study |
| title_full | Factors Associated With Low Lean Mass in Early Rheumatoid Arthritis: A Cross- Sectional Study |
| title_fullStr | Factors Associated With Low Lean Mass in Early Rheumatoid Arthritis: A Cross- Sectional Study |
| title_full_unstemmed | Factors Associated With Low Lean Mass in Early Rheumatoid Arthritis: A Cross- Sectional Study |
| title_short | Factors Associated With Low Lean Mass in Early Rheumatoid Arthritis: A Cross- Sectional Study |
| title_sort | factors associated with low lean mass in early rheumatoid arthritis a cross sectional study |
| topic | rheumatoid arthritis early arthritis body composition sarcopenia lean mass |
| url | https://www.mdpi.com/1010-660X/55/11/730 |
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