Straightforward synthesis of a tetrasaccharide repeating unit corresponding to the O-antigen of Escherichia coli O16
A straightforward synthesis of the tetrasaccharide repeating unit of the O-antigen of Escherichia coli O16 has been achieved following a sequential glycosylation strategy. A minimum number of steps was used for the synthesis of the target compound involving a one-pot glycosylation and a protecting g...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Beilstein-Institut
2013-08-01
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| Series: | Beilstein Journal of Organic Chemistry |
| Subjects: | |
| Online Access: | https://doi.org/10.3762/bjoc.9.203 |
| _version_ | 1818413078749904896 |
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| author | Manas Jana Anup Kumar Misra |
| author_facet | Manas Jana Anup Kumar Misra |
| author_sort | Manas Jana |
| collection | DOAJ |
| description | A straightforward synthesis of the tetrasaccharide repeating unit of the O-antigen of Escherichia coli O16 has been achieved following a sequential glycosylation strategy. A minimum number of steps was used for the synthesis of the target compound involving a one-pot glycosylation and a protecting group manipulation. All intermediate reactions afford their products in high yield, and the glycosylation steps are stereoselective. |
| first_indexed | 2024-12-14T10:57:29Z |
| format | Article |
| id | doaj.art-f3e3f2af1af04770a3318a1358a8ec51 |
| institution | Directory Open Access Journal |
| issn | 1860-5397 |
| language | English |
| last_indexed | 2024-12-14T10:57:29Z |
| publishDate | 2013-08-01 |
| publisher | Beilstein-Institut |
| record_format | Article |
| series | Beilstein Journal of Organic Chemistry |
| spelling | doaj.art-f3e3f2af1af04770a3318a1358a8ec512022-12-21T23:04:53ZengBeilstein-InstitutBeilstein Journal of Organic Chemistry1860-53972013-08-01911757176210.3762/bjoc.9.2031860-5397-9-203Straightforward synthesis of a tetrasaccharide repeating unit corresponding to the O-antigen of Escherichia coli O16Manas Jana0Anup Kumar Misra1Bose Institute, Division of Molecular Medicine, P-1/12, C.I.T. Scheme VII-M, Kolkata-700054, India, Fax: 91-33-2355 3886Bose Institute, Division of Molecular Medicine, P-1/12, C.I.T. Scheme VII-M, Kolkata-700054, India, Fax: 91-33-2355 3886A straightforward synthesis of the tetrasaccharide repeating unit of the O-antigen of Escherichia coli O16 has been achieved following a sequential glycosylation strategy. A minimum number of steps was used for the synthesis of the target compound involving a one-pot glycosylation and a protecting group manipulation. All intermediate reactions afford their products in high yield, and the glycosylation steps are stereoselective.https://doi.org/10.3762/bjoc.9.203Escherichia coliglycosylationlipopolysaccharideO-antigentetrasaccharide |
| spellingShingle | Manas Jana Anup Kumar Misra Straightforward synthesis of a tetrasaccharide repeating unit corresponding to the O-antigen of Escherichia coli O16 Beilstein Journal of Organic Chemistry Escherichia coli glycosylation lipopolysaccharide O-antigen tetrasaccharide |
| title | Straightforward synthesis of a tetrasaccharide repeating unit corresponding to the O-antigen of Escherichia coli O16 |
| title_full | Straightforward synthesis of a tetrasaccharide repeating unit corresponding to the O-antigen of Escherichia coli O16 |
| title_fullStr | Straightforward synthesis of a tetrasaccharide repeating unit corresponding to the O-antigen of Escherichia coli O16 |
| title_full_unstemmed | Straightforward synthesis of a tetrasaccharide repeating unit corresponding to the O-antigen of Escherichia coli O16 |
| title_short | Straightforward synthesis of a tetrasaccharide repeating unit corresponding to the O-antigen of Escherichia coli O16 |
| title_sort | straightforward synthesis of a tetrasaccharide repeating unit corresponding to the o antigen of escherichia coli o16 |
| topic | Escherichia coli glycosylation lipopolysaccharide O-antigen tetrasaccharide |
| url | https://doi.org/10.3762/bjoc.9.203 |
| work_keys_str_mv | AT manasjana straightforwardsynthesisofatetrasacchariderepeatingunitcorrespondingtotheoantigenofescherichiacolio16 AT anupkumarmisra straightforwardsynthesisofatetrasacchariderepeatingunitcorrespondingtotheoantigenofescherichiacolio16 |