RIPK1 inhibition attenuates experimental autoimmune arthritis via suppression of osteoclastogenesis

RIPK1 inhibition attenuates experimental autoimmune arthritis via suppression of osteoclastogenesis

Abstract Background Rheumatoid arthritis (RA) is a chronic and systemic inflammatory disease characterized by upregulation of inflammatory cell death and osteoclastogenesis. Necrostatin (NST)-1s is a chemical inhibitor of receptor-interacting serine/threonine-protein kinase (RIPK)1, which plays a ro...

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Bibliographic Details
Main Authors: Jooyeon Jhun, Seung Hoon Lee, Se-Young Kim, Jaeyoon Ryu, Ji Ye Kwon, Hyun Sik Na, KyoungAh Jung, Su-Jin Moon, Mi-La Cho, Jun-Ki Min
Format: Article
Language:English
Published: BMC 2019-03-01
Series:Journal of Translational Medicine
Subjects:
Rheumatoid arthritis
Necrostatin-1s
Osteoclastogenesis
Necroptosis
Online Access:http://link.springer.com/article/10.1186/s12967-019-1809-3

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