Role of Magnetic Resonance Spectroscopy in the Evaluation of Ring Enhancing Lesions of the Brain
Introduction: The ring enhancing lesions of the brain are a challenging group of lesions with the variable possibilities of diagnosis under conventional Magnetic Resonance Imaging (MRI). Employing advanced techniques such as Magnetic Resonance Spectroscopy (MRS) could increase the success rates...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
JCDR Research and Publications Private Limited
2020-10-01
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| Series: | Journal of Clinical and Diagnostic Research |
| Subjects: | |
| Online Access: | https://jcdr.net/articles/PDF/14133/44973_CE[Ra1]_F(SHU)_PF1(AG_KM)_PFA(KM)_PB(AG_KM)_PN(SL).pdf |
| Summary: | Introduction: The ring enhancing lesions of the brain are a
challenging group of lesions with the variable possibilities of
diagnosis under conventional Magnetic Resonance Imaging
(MRI). Employing advanced techniques such as Magnetic
Resonance Spectroscopy (MRS) could increase the success
rates of the diagnosis.
Aim: To assess the role of MRS in evaluating varying ring
enhancing lesions of the brain.
Materials and Methods: This prospective observational study
involved 50 patients aged between 3-82 years who were detected
with ring enhancing lesions of the brain on contrast MR studies.
The patients underwent MRS evaluation. Categorical data was
represented as frequency (%). The metabolite peaks of choline,
lipid, lactate, N-Acetyl Aspartate (NAA), succinate and amino
acids were recorded. The choline/creatine ratio was calculated
and associated with the type of lesion the patients exhibited.
Results: Among the 50 patients screened, the most prevalent
pathologies were tuberculoma (36%) and neurocysticercosis
(22%). While the patients diagnosed with tuberculoma presented
with higher peak level of lipids and choline/creatine ratio of
>1-2. Increased lactate, succinate, choline peak concomitant
with no or insignificant lipid peak, were noted in the cases of
neurocysticercosis. Primary brain tumour showed high choline
peaks and elevated choline/creatine ratio (>2). Metastasis
showed increased choline peak. Cerebral abscess showed
increased amino acids and lactate peak.
Conclusion: The diagnosis of varying ring enhancing lesions of
the brain was accurately investigated by MRS. This accuracy
enables delineating a treatment plan void of any dilemma. |
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| ISSN: | 2249-782X 0973-709X |