SARS-CoV-2 pneumonia—receptor binding and lung immunopathology: a narrative review
Abstract The current pandemic of COVID-19 caused thousands of deaths and healthcare professionals struggle to properly manage infected patients. This review summarizes information about SARS-CoV-2 receptor binding dynamics and intricacies, lung autopsy findings, immune response patterns, evidence-ba...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2021-02-01
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| Series: | Critical Care |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13054-020-03399-z |
| _version_ | 1818417657600278528 |
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| author | Maria Clara Saad Menezes Diego Vinicius Santinelli Pestana Gustavo Rosa Gameiro Luiz Fernando Ferraz da Silva Ėlodie Baron Jean-Jacques Rouby José Otavio Costa Auler Jr |
| author_facet | Maria Clara Saad Menezes Diego Vinicius Santinelli Pestana Gustavo Rosa Gameiro Luiz Fernando Ferraz da Silva Ėlodie Baron Jean-Jacques Rouby José Otavio Costa Auler Jr |
| author_sort | Maria Clara Saad Menezes |
| collection | DOAJ |
| description | Abstract The current pandemic of COVID-19 caused thousands of deaths and healthcare professionals struggle to properly manage infected patients. This review summarizes information about SARS-CoV-2 receptor binding dynamics and intricacies, lung autopsy findings, immune response patterns, evidence-based explanations for the immune response, and COVID-19-associated hypercoagulability. |
| first_indexed | 2024-12-14T12:10:16Z |
| format | Article |
| id | doaj.art-f3e9f1166a15439691e1aa9f0cb6e37b |
| institution | Directory Open Access Journal |
| issn | 1364-8535 |
| language | English |
| last_indexed | 2024-12-14T12:10:16Z |
| publishDate | 2021-02-01 |
| publisher | BMC |
| record_format | Article |
| series | Critical Care |
| spelling | doaj.art-f3e9f1166a15439691e1aa9f0cb6e37b2022-12-21T23:01:46ZengBMCCritical Care1364-85352021-02-0125111310.1186/s13054-020-03399-zSARS-CoV-2 pneumonia—receptor binding and lung immunopathology: a narrative reviewMaria Clara Saad Menezes0Diego Vinicius Santinelli Pestana1Gustavo Rosa Gameiro2Luiz Fernando Ferraz da Silva3Ėlodie Baron4Jean-Jacques Rouby5José Otavio Costa Auler Jr6Anesthesiology and Intensive Care Department, Instituto Do Coração (InCor), Hospital das Clínicas HCFMUSP, Faculdade de Medicina, Universidade de Sao PauloAnesthesiology and Intensive Care Department, Instituto Do Coração (InCor), Hospital das Clínicas HCFMUSP, Faculdade de Medicina, Universidade de Sao PauloAnesthesiology and Intensive Care Department, Instituto Do Coração (InCor), Hospital das Clínicas HCFMUSP, Faculdade de Medicina, Universidade de Sao PauloDepartment of Pathology, Faculdade de Medicina, Universidade de Sao PauloMultidisciplinary Intensive Care Unit, Department of Anaesthesiology and Critical Care Medicine, La Pitié-Salpêtrière Hospital, Assistance-Publique-Hôpitaux-de-Paris, Sorbonne UniversityMultidisciplinary Intensive Care Unit, Department of Anaesthesiology and Critical Care Medicine, La Pitié-Salpêtrière Hospital, Assistance-Publique-Hôpitaux-de-Paris, Sorbonne UniversityAnesthesiology and Intensive Care Department, Instituto Do Coração (InCor), Hospital das Clínicas HCFMUSP, Faculdade de Medicina, Universidade de Sao PauloAbstract The current pandemic of COVID-19 caused thousands of deaths and healthcare professionals struggle to properly manage infected patients. This review summarizes information about SARS-CoV-2 receptor binding dynamics and intricacies, lung autopsy findings, immune response patterns, evidence-based explanations for the immune response, and COVID-19-associated hypercoagulability.https://doi.org/10.1186/s13054-020-03399-zCOVID-19SARS-CoV-2 pneumoniaACE2PathologyAcute respiratory distress syndromeImmunology |
| spellingShingle | Maria Clara Saad Menezes Diego Vinicius Santinelli Pestana Gustavo Rosa Gameiro Luiz Fernando Ferraz da Silva Ėlodie Baron Jean-Jacques Rouby José Otavio Costa Auler Jr SARS-CoV-2 pneumonia—receptor binding and lung immunopathology: a narrative review Critical Care COVID-19 SARS-CoV-2 pneumonia ACE2 Pathology Acute respiratory distress syndrome Immunology |
| title | SARS-CoV-2 pneumonia—receptor binding and lung immunopathology: a narrative review |
| title_full | SARS-CoV-2 pneumonia—receptor binding and lung immunopathology: a narrative review |
| title_fullStr | SARS-CoV-2 pneumonia—receptor binding and lung immunopathology: a narrative review |
| title_full_unstemmed | SARS-CoV-2 pneumonia—receptor binding and lung immunopathology: a narrative review |
| title_short | SARS-CoV-2 pneumonia—receptor binding and lung immunopathology: a narrative review |
| title_sort | sars cov 2 pneumonia receptor binding and lung immunopathology a narrative review |
| topic | COVID-19 SARS-CoV-2 pneumonia ACE2 Pathology Acute respiratory distress syndrome Immunology |
| url | https://doi.org/10.1186/s13054-020-03399-z |
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